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Ziprasidone has been shown to be an antagonist at both serotonin type 2A 5HT2A and dopamine type 2 D2 receptors. It is proposed that the therapeutic activity is mediated, in part, through this combination of antagonist activities.

Ziprasidone is also a potent antagonist at 5HT2C and 5HT1D receptors, a potent agonist at the 5HT1A receptor and inhibits neuronal reuptake of norepinephrine and serotonin. In a 52 week study, ziprasidone was effective in maintaining the clinical improvement during continuation therapy in patients who showed an initial treatment response: there was no clear evidence for a dose-response relationship amongst the ziprasidone groups.

In this study, which included patients with both positive and negative symptoms, ziprasidone's efficacy was demonstrated in both positive and negative symptoms. The incidence of body weight gain, reported as an adverse event in short term 4-6 week schizophrenia studies was low and identical in ziprasidone-treated and placebo-treated patients both 0. In a one-year placebo-controlled study a median weight loss of 1-3 kg was observed in ziprasidone-treated patients compared to a 3 kg median loss in placebo-treated patients.

In a double-blind comparative schizophrenia study, metabolic parameters including weight and fasting levels of insulin, total cholesterol and triglycerides and an insulin resistance IR index were measured. In patients receiving ziprasidone no significant changes from baseline were observed in any of these metabolic parameters.

What are the possible side effects of ziprasidone. What other drugs will affect ziprasidone. Your pharmacist can provide more information about ziprasidone.

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Health Information Library This information does not replace the advice of a doctor. The warning refers to the increased risk of hyperglycemia and diabetes in patients treated with ziprasidone and other atypical antipsychotics. The FDA has received reports of hyperglycemia, in some cases extreme and associated with ketoacidosis, hyperosmolar coma, or death in patients treated with these medications. Some cases of hyperglycemia have resolved upon discontinuation of the atypical antipsychotic while others have required continued antidiabetic treatment.

There have been few such reports in patients taking ziprasidone, which may be due to the limited number of patients being treated with the drug. It is unknown whether ziprasidone is associated with this increased risk because it was not marketed at the time of the studies.

The FDA recommends that all patients treated with atypical antipsychotics be monitored for symptoms of hyperglycemia and undergo fasting blood glucose testing upon presentation. Patients diagnosed with diabetes mellitus should be monitored regularly for loss of glucose control.

Patients with traditional diabetes mellitus risk factors should undergo fasting blood glucose testing at initiation of treatment with atypical antipsychotics. A free weekly diabetes newsletter for Medical Professionals.

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GEODON intramuscular is indicated for acute agitation in schizophrenic patients. Prolongation of the QTc interval is associated in some other drugs with the ability to cause torsade de pointes-type arrhythmia, a potentially fatal polymorphic ventricular tachycardia, and sudden death. In many cases this would lead to the conclusion that other drugs should be tried first.

Geodon is indicated as monotherapy for the acute treatment of manic or mixed episodes associated with bipolar I disorder. Geodon is indicated as an adjunct to lithium or valproate for the maintenance treatment of bipolar I disorder. Efficacy was established in a maintenance trial in adult patients. GEODON intramuscular is indicated for the treatment of acute agitation in schizophrenic patients for whom treatment with ziprasidone is appropriate and who need intramuscular antipsychotic medication for rapid control of agitation.

Schizophrenic patients experiencing agitation often manifest behaviors that interfere with their diagnosis and care, e.

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The day I stopped taking Geodon, I felt alive and happy and I was very productive, no napping at all and I got a good night's sleep. Report 1 StarsRated Geodon for Bipolar I disorder Report Partly my doctors fault because I asked for something that won't make me super drowsy, I felt completely under water and at work took 4 hours to come out of it.

Pretty difficult Bipolar I to treat so this was disappointingReport 4 StarsRated Geodon for Depression Report It really helped with my depression n maniaReport 1 StarsRated Geodon for Insomnia Report Report 4 StarsRated Geodon for Depression Report This medicine worked within days of starting it. I had been on Cymbalta, at the highest dose, for about 7 months before Geodon was added as an adjunctive treatment.

I wouldn't downplay the sleepiness side effect. My mood has elevated and I feel better once again.

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Adults and children who are at least 10 years of age may benefit from taking this drug to reduce psychotic symptoms. Unlike many other antipsychotic drugs, Geodon is known to produce little or no weight gain as a side effect. This drug used to control intense thoughts, emotions, and behaviors which may accompany schizophrenia. It may also be used to treat individuals experiencing bipolar with symptoms of mania or mixed episodes symptoms of mania and depression that occur simultaneously or in rapid sequence.

While this medication may help to control the behavior that accompanies schizophrenia or bipolar issues, it will not cure any these mental health conditions. For many mental health treatments that require psychotropic medication, pairing the drug treatment with a type of psychotherapy may help a person achieve better, longer-lasting mental health outcomes.

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The possibility of obtundation, seizure, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. If antiarrhythmic therapy is administered, disopyramide, procainamide, and quinidine carry a theoretical hazard of additive QTprolonging effects that might be additive to those of ziprasidone.

Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids.

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  • What should you tell your doctor if you are considering taking Geodon.

  • If you have ever been addicted to street drugs or prescription medications, let your doctor know before you begin taking Geodon.