Generic Name: Gleevec
What is Gleevec?
This article doesn't have the information I'm looking for. I have a medical question. Part of a class of medicines known as atypical antipsychotic drugs, it works by blocking or lessening the effects of certain chemicals in the brain such as dopamine and serotonin that may be elevated in people with schizophrenia or bipolar disorder. Geodon comes in capsule form and is generally taken twice a day. Side effects of the medicine include drowsiness, dizziness, and headaches.
Depression IntroductionThis video clip introduces depression, including what it is, what causes depression, and how it is treated. Click Geodon Uses for more information on what it is used for, including possible off-label uses. Geodon belongs to a group of medications called atypical or second-generation antipsychotic medications.
It is not entirely known how it works for the treatment of schizophrenia or bipolar disorder. However, it is known that the drug blocks or lessens the effects of several chemicals in the brain. These brain chemicals such as dopamine and serotonin may be elevated in people with schizophrenia or bipolar disorder also known as manic depression.
There is no specific antidote to ziprasidone, and it is not dialyzable. The possibility of multiple drug involvement should be considered. Close medical supervision and monitoring should continue until the patient recovers.
An additive effect of ziprasidone and other drugs that prolong the QT interval cannot be excluded. Therefore, ziprasidone should not be given with:The mechanism of action of ziprasidone, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine type 2 D2 and serotonin type 2 5HT2 antagonism.
As with other drugs having efficacy in bipolar disorder, the mechanism of action of ziprasidone in bipolar disorder is unknown.
Ziprasidone functioned as an antagonist at the D2, 5HT2D, and 5HT1D receptors, and as an agonist at the 5HT1A receptor. Ziprasidone inhibited synaptic reuptake of serotonin and norepinephrine. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of ziprasidone.
Ziprasidone's antagonism of histamine H1 receptors may explain the somnolence observed with this drug.
How should I take Gleevec?
Before using ziprasidone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems heart failure, recent heart attack, slow heartbeat, QT prolongation in the EKGfamily history of certain heart problems QT prolongation in the EKG, sudden cardiac death.
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Talk to your doctor about using ziprasidone safely. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
What should I avoid while taking Gleevec?
See which side effects you should report to your doctor right away. Know how to use your medication, and learn what might happen if you miss a dose. Talk to your healthcare provider if you have any of these conditions. Know what to watch for and get tips for reducing your risks while taking this drug.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Gleevec side effects
Patients should be instructed to report the onset of any conditions that put them at risk for significant electrolyte disturbances, hypokalemia in particular, including but not limited to the initiation of diuretic therapy or prolonged diarrhea. Lifetime carcinogenicity studies were conducted with ziprasidone in Long Evans rats and CD-1 mice.
Ziprasidone had no effect on serum prolactin in rats in a 5-week dietary study at the doses that were used in the carcinogenicity study. Ziprasidone was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow.
There was a reproducible mutagenic response in the Ames assay in one strain of S. Positive results were obtained in both the in vitro mammalian cell gene mutation assay and the in vitro chromosomal aberration assay in human lymphocytes. In animal studies ziprasidone demonstrated developmental toxicity, including possible teratogenic effects at doses similar to human therapeutic doses.
Common Gleevec ide effects may include:
For general information, see Learn About Clinical Studies.
Do not stop using ziprasidone suddenly, even if you feel fine.
An increase to a dose greater than 80 mg twice daily is not generally recommended.
We help individuals decrease their dependency upon antipsychotic medications, other drugs, and dependency to alcohol with our medical professionals.
Seizures Caution is recommended when treating patients with a history of seizures. Hepatic Impairment There is a lack of experience in patients with severe hepatic insufficiency and ziprasidone should be used with caution in this group see sections 4. Geodon is not licensed for the treatment of dementia-related behavioural disturbances.
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Tell your doctor about all medicines you use.