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Prolongation of the QTc interval is associated in some other drugs with the ability to cause torsade de pointes-type arrhythmia, a potentially fatal polymorphic ventricular tachycardia, and sudden death.
In many cases this would lead to the conclusion that other drugs should be tried first. Geodon is indicated as monotherapy for the acute treatment of manic or mixed episodes associated with bipolar I disorder. Geodon is indicated as an adjunct to lithium or valproate for the maintenance treatment of bipolar I disorder.
Efficacy was established in a maintenance trial in adult patients. GEODON intramuscular is indicated for the treatment of acute agitation in schizophrenic patients for whom treatment with ziprasidone is appropriate and who need intramuscular antipsychotic medication for rapid control of agitation.
Schizophrenic patients experiencing agitation often manifest behaviors that interfere with their diagnosis and care, e. Since there is no experience regarding the safety of administering ziprasidone intramuscular to schizophrenic patients already taking oral ziprasidone, the practice of co-administration is not recommended.
Cimetidine Cimetidine at a dose of 800 mg QD for 2 days did not affect ziprasidone pharmacokinetics. Lithium Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. Oral Contraceptives In vivo studies have revealed no effect of ziprasidone on the pharmacokinetics of estrogen or progesterone components.
Dextromethorphan Consistent with in vitro results, a study in normal healthy volunteers showed that ziprasidone did not alter the metabolism of dextromethorphan, a CYP2D6 model substrate, to its major metabolite, dextrorphan. Valproate A pharmacokinetic interaction of ziprasidone with valproate is unlikely due to the lack of common metabolic pathways for the two drugs. Other Concomitant Drug Therapy Population pharmacokinetic analysis of schizophrenic patients enrolled in controlled clinical trials has not revealed evidence of any clinically significant pharmacokinetic interactions with benztropine, propranolol, or lorazepam.
Drug Abuse And Dependence Dependence Ziprasidone has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence. Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Neuroleptic Malignant Syndrome NMS A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with administration of antipsychotic drugs.
Severe Cutaneous Adverse Reactions Drug Reaction With Eosinophilia And Systemic Symptoms DRESS Drug Reaction with Eosinophilia and Systemic Symptoms DRESS has been reported with Ziprasidone exposure. Other Severe Cutaneous Adverse Reactions Other severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, have been reported with ziprasidone exposure.
Tardive Dyskinesia A syndrome of potentially irreversible, involuntary, dyskinetic movements may develop in patients undergoing treatment with antipsychotic drugs. Hyperglycemia And Diabetes Mellitus Hyperglycemia and diabetes mellitus, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, have been reported in patients treated with atypical antipsychotics.
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ContinuePRINT From Mental Health Resources Bipolar or Schizophrenia. What should I discuss with my healthcare provider before taking ziprasidone Geodon. How should I take ziprasidone Geodon. What happens if I miss a dose Geodon. What happens if I overdose Geodon. What should I avoid while taking ziprasidone Geodon.
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Treatment Indications Dosage FAQs Considerations Before Use Safety Considerations Possible Side Effects How to Safely Withdraw Treatment Indications This drug used to control intense thoughts, emotions, and behaviors which may accompany schizophrenia. Dosage FAQs How can I take Geodon safely. Geodon may come in capsule form ziprasidone hydrochloride for oral administration, or as an injection ziprasidone mesylate for intramuscular application only.
This drug is usually taken twice per day with food.
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These studies included approximately 850 patients meeting DSM-IV criteria for bipolar I disorder with an acute manic or mixed episode, with or without psychotic features. Ziprasidone treatment 40-80 mg BID, mean daily dose 120 mg resulted in statistically significantly greater improvement in both MRS and CGI-S scores at Last Visit 3 weeks compared with placebo. In the 12 week study, haloperidol treatment mean daily dose 16 mg produced significantly greater reductions in MRS scores compared with ziprasidone mean daily dose 121 mg.
Ziprasidone demonstrated comparable efficacy to haloperidol in terms of the proportion of patients maintaining a response to treatment from week 3 to week 12. Asymmetric dosing, with morning doses 20 mg or 40 mg less than evening doses, was permitted. Ziprasidone was superior to placebo in change from baseline to week 4 on the Y-MRS total score. In a 4-week trial in paediatric patients 10-17 years with bipolar mania, there were no differences between ziprasidone and placebo patients in the mean change from baseline in body weight fasting glucose, total cholesterol, LDL cholesterol, or triglyceride levels.
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I wouldn't downplay the sleepiness side effect.
For people who want to avoid age related decline and enhance their memories and focus, there are better solutions available.
Therefore, it is important to tell your doctor about any other medicines that you take, including non-prescription medicines, supplements, and herbal medicines.
Prior results do not guarantee or predict a similar outcome with respect to any future matter.
GEODON is a registered trademark of Pfizer Inc. Other brands listed are trademarks of their respective owners. Terms and conditions apply.
Where can I get more information?
I quit taking them 2 days ago and I still feel like this.
If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered.