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Ensure an adequate airway, oxygenation, and ventilation. Activated charcoal should be administered. Due to the large volume of distribution of this drug, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. No specific antidotes for fluoxetine are known. A specific caution involves patients who are taking or have recently taken fluoxetine and might ingest excessive quantities of a TCA.
For specific information about overdosage with olanzapine and fluoxetine in combination, refer to the Overdosage section of the Symbyax package insert. When using PROZAC and olanzapine in combination, also refer to the Contraindications section of the package insert for Symbyax.
The use of MAOIs intended to treat psychiatric disorders with PROZAC or within 5 weeks of stopping treatment with PROZAC is contraindicated because of an increased risk of serotonin syndrome. Pimozide and thioridazine prolong the QT interval.
The risk or severity of adverse effects can be increased when Halazepam is combined with Fluoxetine. The serum concentration of the active metabolites of Hydrocodone can be reduced when Hydrocodone is used in combination with Fluoxetine resulting in a loss in efficacy. The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Fluoxetine. The risk or severity of adverse effects can be increased when Fluoxetine is combined with Imipramine.
The risk or severity of adverse effects can be increased when Ketamine is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Levocabastine is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Levocetirizine is combined with Fluoxetine.
The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Fluoxetine. The therapeutic efficacy of Liothyronine can be decreased when used in combination with Fluoxetine.
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Alprazolam: Clinical study results suggest that the interaction between alprazolam, a CYP3A4 substrate fluoxetine, a CYP3A4 inhibitor may be of clinical significance, and caution is recommended during co-administration. Monitor patients closely for excessive alprazolam-related side effects. Alteplase, tPA: Platelet aggregation may be impaired by selective serotonin reuptake inhibitors SSRIs due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication in patients receiving thrombolytic agents.
Patients should be closely monitored for signs and symptoms of bleeding when a thrombolytic agent is administered with an SSRI.
Ambrisentan: In vitro studies indicate ambrisentan is a substrate of CYP2C19, although in vivo studies with omeprazole, a CYP2C19 inhibitor, did not demonstrate a clinically significant drug-drug interaction. Although data are lacking, significant CYP2C19 inhibitors, such as fluoxetine, could potentially increase ambrisentan plasma concentrations via CYP2C19 inhibition. Monitor for increased toxicity as well as increased therapeutic effect during times of coadministration Amiloride: Patients receiving a diuretic during treatment with fluoxetine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH.
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The possibility of pharmacodynamic or pharmacokinetic interaction between fluoxetine and melatonin should be considered in this case. Meperidine: Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering selective serotonin reuptake inhibitors SSRIs with other drugs that have serotonergic properties such as meperidine. A 42-year-old man became agitated, restless, diaphoretic, tachycardic, and hypertensive immediately after receipt of meperidine 50 mg intravenously.
Two weeks before the incident, the patient had stopped a regimen of the SSRI, fluoxetine. Serotonin syndrome was suspected, as fluoxetine and norfluoxetine have long half-lives, and previous meperidine receipt during a time when the patient had not been taking fluoxetine was uneventful. If serotonin syndrome is suspected, the SSRI and concurrent serotonergic agents should be discontinued.
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This study limited itself to just asking patients how they felt. Randomised, double-blind, placebo-controlled treatment trial of fluoxetine and graded exercise for chronic fatigue syndrome - Editor: Graded exercise produced improvements in functional work capacity and fatigue, while fluoxetine improved depression only.
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In children and adolescents aged eight years and over fluoxetine is used to treat:Prozac capsules and liquid contain the active ingredient fluoxetine, which is a type of antidepressant known as a selective serotonin reuptake inhibitor SSRI.
Fluoxetine is also available without a brand name, ie as the generic medicine. Antidepressant medicines act on nerve cells in the brain.
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Serotonin Syndrome Patients should be cautioned about the risk of serotonin syndrome with the concomitant use of PROZAC and other serotonergic agents including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St.
Electrolyte imbalances should be corrected prior to initiating treatment with fluoxetine.
Fluoxetine is available only on prescription as tablets and capsules.
As always, talk with your health care provider regarding questions you have about your medications and interactions between medications and supplements.
Perphenazine: Because perphenazine and some SSRIs including fluoxetine are associated with a possible risk of QT prolongation and torsade de pointes TdPcombination therapy should be used cautiously and with close monitoring. Because perphenazine and some SSRIs including fluoxetine are associated with a possible risk of QT prolongation and torsade de pointes TdPcombination therapy should be used cautiously and with close monitoring.
Phenelzine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with selective serotonin reuptake inhibitors SSRIs.
Regular appointments to assess the efficacy of the weight loss treatment, the emergence of adverse events, and blood pressure monitoring are recommended.
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For depression, the length of treatment will depend on how quickly your symptoms improve.
A register-based retrospective nationwide cohort study, using the Danish Medical Birth Registry observed that risks of congenital malformations of the heart were similar for pregnancies exposed to an SSRI throughout the first trimester, adjusted OR 2.