Generic Name: Feldene
What is Feldene?
Levobetaxolol: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Levobunolol: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Levomilnacipran: Platelet aggregation may be impaired by SNRIs such as levomilnacipran due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication e.
Monitor for signs and symptoms of bleeding in patients taking levomilnacipran and NSAIDs. Lisinopril: In the low-renin or volume-dependent hypertensive patient, prostaglandins play an important role in the hypotensive effects of ACE inhibitors. Lithium: Lithium levels should be monitored when patients initiate or discontinue nonsteroidal antiinflammatory drugs. In some cases, lithium toxicity has resulted from interactions between an NSAID and lithium. Indomethacin and piroxicam have been reported to significantly increase steady-state plasma lithium concentrations.
There is also evidence that other NSAIDs, including the selective cyclooxygenase-2 COX-2 inhibitors, have the same effect. It is thought that prostaglandins are involved in the renal clearance of lithium and that NSAIDs interfere with lithium excretion. Typically, increased lithium levels develop over 5 to 10 days after adding a NSAID and return to pretreatment levels within 7 days of stopping the NSAID. Lomustine, CCNU: Due to the bone marrow suppressive and thrombocytopenic effects of lomustine, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants, NSAIDs, platelet inhibitors, including aspirin, ASA, strontium-89 chloride, and thrombolytic agents.
Serious GI ComplicationsIdentification of at-risk subjectsThe risk for developing serious GI complications increases with age. Age over 70 years is associated with high risk of complications. The administration to patients over 80 years should be avoided. Patients taking concomitant oral corticosteroids, selective serotonin reuptake inhibitors SSRIs or anti-platelet agents such as low-dose acetylsalicylic acid are at increased risk of serious GI complications see below and section 4. As with other NSAIDs, the use of piroxicam in combination with protective agents e.
Patients should be asked to report any new or unusual abdominal symptom during treatment. If a gastrointestinal complication is suspected during treatment, piroxicam should be discontinued immediately and additional clinical evaluation and treatment should be considered.
Similar consideration should be made before initiating longer-term treatment of patients with risk factors for cardiovascular events e. Clinical trial and epidemiological data suggest that use of some NSAIDs particularly at high doses and in long term treatment may be associated with a small increased risk of arterial thrombotic events for example myocardial infarction or stroke. There are insufficient data to exclude such a risk for Feldene.
Feldene should be used with caution in patients with a history of bronchial asthma see also section 4. Skin reactionsLife-threatening cutaneous reactions Stevens-Johnson syndrome SJS and toxic epidermal necrolysis TEN have been reported with the use of piroxicam.
How should I take Feldene?
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What should I avoid while taking Feldene?
Advise patients to report symptoms of ulcerations and bleeding, including epigastric pain, dyspepsia, melena, and hematemesis to their health care provider. Inform patients of the signs of an anaphylactic reaction e. Inform patients that the concomitant use of FELDENE with other NSAIDs or salicylates e.
Alert patients that NSAIDs may be present in "over the counter" medications for treatment of colds, fever, or insomnia. Long-term animal studies have not been conducted to characterize the carcinogenic potential of piroxicam. Piroxicam was not mutagenic in an Ames bacterial reverse mutation assay, or in a dominant lethal mutation assay in mice, and was not clastogenic in an in vivo chromosome aberration assay in mice. Use of NSAIDs, including FELDENE, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus.
Feldene side effects
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Your physician might also recommend some antacid medicines to be used with Feldene. If you have been prescribed antacids, chew up the antacid prior to gulping it down and use it simultaneously with Feldene Flash Piroxicam. If you have been prescribed the Feldene dispersible medicine, liquefy it in about 50 mL of water, stir well before drinking it.
Your doctor has weighed the risks of you taking FELDENE against the benefits they expect it will have for you.
Common Feldene ide effects may include:
Hematologic Toxicity Anemia has occurred in NSAID-treated patients.
Prescription Settings generic capsule 20mg 30 capsules Enter a custom quantity Set Save MyRx Drug Limit You can only add a maximum of 25 drugs to MyRx.
Clinical Considerations Labor or Delivery There are no studies on the effects of FELDENE during labor or delivery.
NSAIDs are a substrate of UDP-glucuronyltransferases.
It is nonsteroidal anti-inflammatory drug NSAIDs. Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.
More about Feldene
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Where can I get more information?
NSAIDs are used to relieve pain and inflammation.
Do not start taking any new medicine without talking to your healthcare provider first.