Generic Name: Feldene
What is Feldene?
Mycophenolate: NSAIDs should be used with caution in patients receiving immunosuppressives as they may mask fever, pain, swelling and other signs and symptoms of an infection. Nabumetone: Avoid concomitant use of nabumetone with any other NSAID, including COX-2 inhibitors, due to the risk of additive serious NSAID toxicities including but not limited to GI bleeding, GI perforation, or peptic ulcers. Nadolol: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control.
Naproxen: Avoid concomitant use of naproxen with any other NSAID, including COX-2 inhibitors, due to the risk of additive serious NSAID toxicities including but not limited to GI bleeding, GI perforation, or peptic ulcers. Nebivolol: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control.
Nonsteroidal antiinflammatory drugs NSAIDs including selective COX-2 inhibitors may alter the response to Angiotensin II receptor blockers due to inhibition of vasodilatory prostaglandins.
Nelarabine: Due to the thrombocytopenic effects of nelarabine, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants, NSAIDs, platelet inhibitors, including aspirin, strontium-89 chloride, and thrombolytic agents. Neomycin: It is possible that additive nephrotoxicity may occur in patients who receive NSAIDs concurrently with other nephrotoxic agents, such as aminoglycosides.
However, even short-term NSAID therapy is not without risk. Most postmarketing reports of fatal GI events occurred in elderly or debilitated patients. In addition, rare, sometimes fatal, cases of severe hepatic injury, including fulminant hepatitis, liver necrosis, and hepatic failure have been reported. Inform patients of the warning signs and symptoms of hepatotoxicity e. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur e.
NSAIDs, including FELDENE, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events.
Monitor blood pressure BP during the initiation of NSAID treatment and throughout the course of therapy. The Coxib and traditional NSAID Trialists' Collaboration meta-analysis of randomized controlled trials demonstrated an approximately twofold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. In a Danish National Registry study of patients with heart failure, NSAID use increased the risk of MI, hospitalization for heart failure, and death.
Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs.
How should I take Feldene?
The therapeutic effects of FELDENE are evident early in the treatment of both diseases with a progressive increase in response over several 8-12 weeks. Efficacy is seen in terms of pain relief and, when present, subsidence of inflammation. FELDENE has been administered concomitantly with fixed doses of gold and corticosteroids. The existence of a "steroid sparing" effect has not been adequately studied to date.
What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory Drugs NSAIDs.
What should I avoid while taking Feldene?
In conclusion, this new information indicates that there are only a few indications where the use of these drugs is recommended during IVF treatment. As always, if in doubt, discuss the use of these drugs with your specialist. Started by Romeo VoidJun 17 2005 12:23 PM Please log in to reply 15 replies to this topic 1 Romeo Void Posted 17 June 2005 - 12:23 PM My RE handed me a Feldene tablet and told me to take it 2 hours prior to transfer.
This message was edited by white2sugars on Friday, 17 June 2005 12:27 PM ipb. This message was edited by diva on Friday, 17 June 2005 1:19 PM ipb. Checked the side effect profile for piroxicam, and sure enough skin rashes and lesions are mentioned as a side effect.
I'm stopping this drug today.
Feldene side effects
Feldene Questions and Answers We shall now present to you several frequently asked questions by people who are thinking of taking Feldene or Piroxicam, below each of these questions you will find the answers you are looking for, if you do have any other questions or wish to know whether these two drugs are going to be beneficial to you in treating the arthritis then please do have a chat wit h your Doctor for if these two drugs are not ideal for you then he or she will be able to advise an alternative course of medication that will be more suitable to you.
Will Feldene get rid of the pain caused by Golfers elbow. In the elderly, who are more prone to adverse events, the lowest dose compatible with adequate safe clinical control should be employed. Occlusive dressings should not be used. Treatment should be reviewed at regular intervals and discontinued if no benefit is seen or if intolerance occurs.
Method of administrationFeldene Gel is for external use only.
Common Feldene ide effects may include:
The manufacturer of clopidogrel advises that caution be used when used in combination with NSAIDs as an increase in occult GI blood loss occurred when clopidogrel was used concomitantly with naproxen Cisplatin: Although the thrombocytopenic effects of cisplatin are limited, an additive risk of bleeding may be seen in patients receiving concomitant therapy with non-steroidal antiinflammatory agents NSAIDs.
Bendamustine: An increased risk of bleeding may occur when NSAIDs are used with agents that cause clinically significant thrombocytopenia.
Piroxicam may cause premature closure of the fetal ductus arteriosus.
Diuretics: Non-steroidal anti-inflammatory drugs may cause sodium, potassium and fluid retention and may interfere with the natriuretic action of diuretic agents.
If this happens, do not drive or do things that could be dangerous if you are not alert. Check with your doctor as soon as possible if you have any problems while taking FELDENE, even if you do not think the problems are connected with the medicine or are not listed in this leaflet. Antiinflamatoarele nesteroidiene inhiba sinteza prostaglandinelor renale care joaca un rol de suport in mentinerea perfuziei renale la pacientii cu flux sanguin renal si volum sanguin scazute.
La acesti pacienti administrarea de antiinflamatoare nesteroidiene poate precipita decompensarea renala, care este urmata de revenirea la starea dinaintea tratamentului dupa intreruperea terapiei cu aceste medicamente.
Where can I get more information?
In patients who are elderly, volume-depleted including those on diuretic therapyor with compromised renal function who are being treated with NSAIDs, the coadministration of ACE inhibitors may result in a further deterioration of renal function, including acute renal failure.
The table below contains some of the ones associated with piroxicam gel, although these do not commonly occur.