Generic Name: Evista
What is Evista?
Serious and life-threatening side effects can occur while taking Evista. These include blood clots and dying from stroke:These are not all the possible side effects of Evista. Tell your doctor about any side effect that is bothersome or that does not go away. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:This is not a complete list of Evista drug interactions.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Evista there are no specific foods that you must exclude from your diet when receiving Evista. Tell your doctor if you are pregnant or planning to become pregnant. Evista should not be used in women who are or could become pregnant.
In postmenopausal women with osteoporosis, Evista reduces the incidence of vertebral fractures, preserves bone mass and increases bone mineral density BMD.
Based on these risk factors, prevention of osteoporosis with Evista is indicated for women within ten years of menopause, with BMD of the spine between 1. Likewise, Evista is indicated for the treatment of osteoporosis or established osteoporosis in women with BMD of the spine 2.
Forty five women with osteoporosis or 15 women with osteoporosis with an existing fracture would need to be treated with Evista for 3 years to prevent one or more vertebral fractures. An effect on non-vertebral fractures has not been demonstrated.
From the 4th to the 8th year, patients were permitted the concomitant use of bisphosphonates, calcitonin and fluorides and all patients in this study received calcium and vitamin D supplementation. In the RUTH study overall clinical fractures were collected as a secondary endpoint. These results may have been confounded by baseline differences in BMD and vertebral fractures. There was no difference between treatment groups in the incidence of new nonvertebral fractures.
During the whole length of the study concomitant use of other bone-active medications was permitted. The women were 2 to 8 years postmenopausal. Three trials included 1,764 postmenopausal women who were treated with Evista and calcium or calcium supplemented placebo. In one of these trials the women had previously undergone hysterectomy.
How should I take Evista?
Raloxifene Side effects The only statistically significant side effect of raloxifene in studies of over 15,000 postmenopausal women is hot flushes. Most women say the hot flushes wane with time even without any treatment. The label includes dire warnings about Deep Vein Thrombosis, Pulmonary Embolism, Stroke, and Death from Stroke.
The truth is these things did not happen significantly in any of the research studies. The data does not support the US FDA requiring Lilly to classify these events that occurred in statistically equal numbers of people on raloxifene and placebo side effects of raloxifene.
What should I avoid while taking Evista?
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Coping with Diabetes Hearing Loss Help Treatment for Diabetes Find Infant Formula Aortic Valve Stenosis SUBSCRIBE MedicineNet. Raloxifene belongs to a family of medications called selective estrogen receptor modifiers SERMs.
Evista side effects
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Common Evista ide effects may include:
Took Lyme disease test which was negative.
Recently scientists discovered that Evista, a drug which was being used to treat osteoporosis, also decreased the incidence of breast cancer.
Do not use if you are or may become pregnant.
The mean T scores number of standard deviations above or below the mean in healthy young women for the three trials ranged from -1.
Summary of the safety profileThe clinically most important adverse reactions reported in postmenopausal women treated with Evista were venous thromboembolic events see section 4. Tabulated summary of adverse reactionsThe table below gives the adverse reactions and frequencies observed in treatment and prevention studies involving over 13,000 postmenopausal women along with adverse reactions arising from postmarketing reports.
The duration of treatment in these studies ranged from 6 to 60 months.
Where can I get more information?
Hepatic impairment including cholestasis.
Mutagenesis - Raloxifene HCl was not genotoxic in any of the following test systems: the Ames test for bacterial mutagenesis with and without metabolic activation, the unscheduled DNA synthesis assay in rat hepatocytes, the mouse lymphoma assay for mammalian cell mutation, the chromosomal aberration assay in Chinese hamster ovary cells, the in vivo sister chromatid exchange assay in Chinese hamsters, and the in vivo micronucleus test in mice.