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Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis, kidney problems, liver problems such as hepatitis B or C, cirrhosisalcohol use. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Caution is advised when using this drug in children because they may be more sensitive to the effects of the drug, especially the increased risk of pancreatitis. Kidney function declines as you grow older. This medication is removed by the kidneys.
Therefore, caution is advised when using this drug in older adults because they may be more sensitive to the effects of the drug. Lamivudine may be part of that treatment.
The dosage of epivir should be strictly as prescribed by the doctor. Recommendations Epivir is used for the treatment of acquired immuno deficiency syndrome popularly known as AIDS. Epivir may not offer complete cure from AIDS but can very well arrest the spread of the virus infection. The epivir can also be used for the treatment of hepatitis B virus infection. Epivir can also be used on the people healthcare workers and others persons who are exposed to the HIV infection because of the close proximity to the infected persons.
These persons are likely to be infected accidentally by coming in to contact with contaminated tissue, blood, or any other body fluid. The doctors need to be informed if you are allergic to epivir. The doctor should be informed about the other medications that you are consuming either prescribed by the doctor or by yourself.
If you are consuming trimethoprim or sulfamethoxazole and the same should be informed to the doctor. The doctor has to be intimated in case you had or have kidney disease, pancrease disease or hepatitis B. The breast feeding mother should never consume epivir. Precautions There are few possible side effects of the epivir which are listed below. They are chills, fatigue, headache, diarrhea,nausea,vomiting, dizziness, depression, loss of appetite, troubled sleep, stuffy nose, cough etc.
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Serious side effects include liver disease, lactic acidosis, and worsening hepatitis B among those already infected. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver.
Long-term use of lamivudine leads to emergence of a resistant hepatitis B virus YMDD mutant. Despite this, lamivudine is still used widely as it is well tolerated. The COLATE study has suggested that there is no benefit to continuing lamivudine treatment in patients with lamivudine resistance. In hepatitis B, lamivudine resistance was first described in the YMDD tyrosine-methionine-aspartate-aspartate locus of the HBV reverse transcriptase gene.
The HBV reverse transcriptase gene is 344 amino acids long and occupies codons 349 to 692 on the viral genome. Lamivudine treatment has been shown to restore zidovudine sensitivity of previously resistant HIV.
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Prescription Settings generic tablet 150mg 30 tablets Enter a custom quantity Set Save MyRx Drug Limit You can only add a maximum of 25 drugs to MyRx. Lamivudine remt dit enzym en voorkomt zo dat nieuwe virussen worden gemaakt. Lamivudine kan het virus niet volledig laten verdwijnen. Wel kan het de hoeveelheid virus in het bloed drastisch verlagen.
Na de geboorte krijgt de baby de eerste 4 weken een combinatie van de hiv-remmers zidovudine en lamivudine. OorzaakHepatitis B is een besmettelijke leverziekte die wordt veroorzaakt door een infectie met het hepatitis B-virus.
Er bestaan verschillende soorten hepatitisvirussen. In dat geval moet u opnieuw lamivudine gebruiken, of een andere virusremmer.
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Liver disease: If lamivudine is being used concomitantly for the treatment of HIV and HBV, additional information relating to the use of lamivudine in the treatment of hepatitis B infection is available in the Zeffix SPC. Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk of severe and potentially fatal hepatic adverse events.
In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant product information for these medicinal products. If Epivir is discontinued in patients co-infected with hepatitis B virus, periodic monitoring of liver function tests and markers of HBV replication is recommended, as withdrawal of lamivudine may result in an acute exacerbation of hepatitis see Zeffix SPC.
Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered see section 4.
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Serious side effects include: Fatty liver Pancreatitis Liver enlargement Rhabdomyolysis Lactic acidosis.
Antiviral Activity The antiviral activity of lamivudine against HIV-1 was assessed in a number of cell lines including monocytes and fresh human peripheral blood lymphocytes PBMCs using standard susceptibility assays.
Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat resistantor worsen side effects.
BiotransformationThe active moiety, intracellular lamivudine triphosphate, has a prolonged terminal half-life in the cell 16 to 19 hours compared to the plasma lamivudine half-life 5 to 7 hours.
Lamivudine kan het virus niet volledig laten verdwijnen. Wel kan het de hoeveelheid virus in het bloed drastisch verlagen. Na de geboorte krijgt de baby de eerste 4 weken een combinatie van de hiv-remmers zidovudine en lamivudine. OorzaakHepatitis B is een besmettelijke leverziekte die wordt veroorzaakt door een infectie met het hepatitis B-virus. Er bestaan verschillende soorten hepatitisvirussen.
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In another controlled study, combination therapy was evaluated in adult patients with HBeAg-positive CHB who had YMDD-mutant HBV and diminished clinical and virologic response to lamivudine.
Pediatric Subjects Clinical Endpoint Trial ACTG300 was a multicenter, randomized, double-blind trial that provided for comparison of EPIVIR plus RETROVIR zidovudine with didanosine monotherapy.