Generic Name: Order epivir
What is Order Epivir?
Lamivudine passeert de placenta. A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 HIV-1 and hepatitis B HBV. Lamivudine is a nucleoside reverse transcriptase inhibitor NRTI with activity against Human Immunodeficiency Virus Type 1 HIV-1 and hepatitis B HBV.
Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate L-TP.
This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. SubstrateEnzymesProductLamivudine Sulfotransferase 1A1 Choline-phosphate cytidylyltransferase A Not Available Not Available Not AvailableThe majority of lamivudine is eliminated unchanged in urine by active organic cationic secretion.
PathwayCategorySMPDB IDLamivudine Metabolism PathwaySMP00649SMP00742DrugInteractionDrug groupAcetaminophenThe serum concentration of Lamivudine can be increased when it is combined with Aminohippuric acid.
The risk or severity of adverse effects can be increased when Lamivudine is combined with Emtricitabine. The risk or severity of adverse effects can be increased when Ganciclovir is combined with Lamivudine.
Lamivudine metabolism does not involve CYP3A, making interactions with medicinal products metabolised by this system e. Animal studies with lamivudine showed an increase in early embryonic deaths in rabbits but not in rats see section 5. Placental transfer of lamivudine has been shown to occur in humans.
Epivir can be used during pregnancy if clinically needed. The malformative risk is unlikely in humans based on those data. For patients co-infected with hepatitis who are being treated with lamivudine and subsequently become pregnant, consideration should be given to the possibility of a recurrence of hepatitis on discontinuation of lamivudine. It is recommended that HIV infected women do not breast-feed their infants under any circumstances in order to avoid transmission of HIV.
FertilityStudies in animals showed that lamivudine had no effect on fertility see section 5. The adverse reactions considered at least possibly related to the treatment are listed below by body system, organ class and absolute frequency. No specific signs or symptoms have been identified following such overdose. If overdosage occurs the patient should be monitored, and standard supportive treatment applied as required.
How should I take Order Epivir?
Antiviral Activity The antiviral activity of lamivudine against HIV-1 was assessed in a number of cell lines including monocytes and fresh human peripheral blood lymphocytes PBMCs using standard susceptibility assays. Resistance Lamivudine-resistant variants of HIV-1 have been selected in cell culture.
Cross-Resistance Cross-resistance has been observed among nucleoside reverse transcriptase inhibitors NRTIs. Clinical Studies The use of EPIVIR is based on the results of clinical trials in HIV-1-infected subjects in combination regimens with other antiretroviral agents.
Pediatric Subjects Clinical Endpoint Trial ACTG300 was a multicenter, randomized, double-blind trial that provided for comparison of EPIVIR plus RETROVIR zidovudine with didanosine monotherapy.
EPIVIR can cause serious side effects, including: Build-up of an acid in your blood lactic acidosis. Lactic acidosis can happen in some people who take EPIVIR. Your liver may become large hepatomegaly and you may develop fat in your liver steatosis.
What should I avoid while taking Order Epivir?
Monitor hepatic function closely for at least several months in these patients. Advise him to take appropriate precautions during sex.
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ActionInhibits HIV reverse transcription by viral DNA chain termination. Co-trimoxazole: increased lamivudine blood levelZalcitabine: interference with effects of both drugsDrug-diagnostic tests. Facebook Twitter My bookmarks. Bottom lines: two steps back.
Order Epivir side effects
Some brands of lamivudine contain one or more other antiretroviral medicine see the list in the table above - these combination brands help to reduce the total number of tablets you need to take each day. Not all of the information in this leaflet applies to the combination brands, so please refer to the manufacturer's printed information leaflet from inside the pack for full details.
It is vital to take your antiretroviral medicines exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life. Lamivudine is also prescribed for another viral infection - there is more information about this in a separate medicine leaflet called Lamivudine for hepatitis B infection.
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking lamivudine it is important that your doctor knows:Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them.
Common Order Epivir ide effects may include:
HIV-1 isolates from these 6 subjects were susceptible to zidovudine.
Trimethoprim may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Since October 1993, the drug has been available to subjects outside of controlled clinical trials under an open-label protocol.
You should not take lamivudine if you are allergic to it.
The chemical name of lamivudine is 2R,cis -4-amino-1- 2-hydroxymethyl-1,3-oxathiolan-5-yl - 1H -pyrimidin-2-one. EPIVIR oral solution is for oral administration. One milliliter 1 mL of EPIVIR oral solution contains 10 mg of lamivudine 10 mg per mL in an aqueous solution and the inactive ingredients artificial strawberry and banana flavors, citric acid anhydrousmethylparaben, propylene glycol, propylparaben, sodium citrate dihydrateand sucrose 200 mg.
This medication may cause lactic acidosis a build-up of lactic acid in the body, which can be fatal. Lactic acidosis can start slowly and get worse over time.
Where can I get more information?
List Epivir side effects by likelihood and severity.
Lamivudine at a dose of 100 mg once daily has also been shown to be effective for the treatment of adult patients with chronic HBV infection for details of clinical studies, see the prescribing information for Zeffix.