Epivir

Generic Name: Epivir

What is Epivir?

This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc.

SubstrateEnzymesProductLamivudine Sulfotransferase 1A1 Choline-phosphate cytidylyltransferase A Not Available Not Available Not AvailableThe majority of lamivudine is eliminated unchanged in urine by active organic cationic secretion. PathwayCategorySMPDB IDLamivudine Metabolism PathwaySMP00649SMP00742DrugInteractionDrug groupAcetaminophenThe serum concentration of Lamivudine can be increased when it is combined with Aminohippuric acid.

The risk or severity of adverse effects can be increased when Lamivudine is combined with Emtricitabine. The risk or severity of adverse effects can be increased when Ganciclovir is combined with Lamivudine.

The serum concentration of Lamivudine can be decreased when it is combined with Platelet Activating Factor. The serum concentration of Lamivudine can be decreased when it is combined with St. Trimethoprim may decrease the excretion rate of Lamivudine which could result in a higher serum level. The risk or severity of adverse effects can be increased when Valganciclovir is combined with Lamivudine.

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Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Epivir may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Epivir.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects in more detail Other drugs may interact with lamivudine, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs should not be used together with Epivir. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Hepatitis B lamivudine, Viread, entecavir, tenofovir, Baraclude, Vemlidy, More. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc.

Drug information contained herein may be time sensitive.

How should I take Epivir?

Who should not take EPIVIR-HBV. You should not take EPIVIR-HBV if you are also taking EPIVIR, COMBIVIR, or TRIZIVIR. You should not take EPIVIR-HBV if you have had an allergic reaction to lamivudine. EPIVIR-HBV has not been studied in children less than 2 years old. How should I take EPIVIR-HBV.

What should I avoid while taking Epivir?

The majority of lamivudine-treated patients showed a decrease of HBV DNA to below the assay limit early in the course of therapy. All patients had compensated chronic hepatitis B accompanied by evidence of hepatitis B virus replication positive serum HBeAg and positive for serum HBV DNA by a research branched-chain DNA assay and persistently elevated serum ALT levels. As in the adult controlled trials, most lamivudine-treated subjects had decreases in HBV DNA below the assay limit early in treatment, but about one third of subjects with this initial response had reappearance of assay-detectable HBV DNA during treatment.

EPIVIR-HBV Tablets and EPIVIR-HBV Oral Solution are contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any of the components of the products.

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including lamivudine and other antiretrovirals. Most of these reports have described patients receiving nucleoside analogues for treatment of HIV infection, but there have been reports of lactic acidosis in patients receiving lamivudine for hepatitis B.

Treatment with EPIVIR or EPIVIR-HBV should be suspended in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity which may include hepatomegaly and steatosis even in the absence of marked transaminase elevations. The formulation and dosage of lamivudine in EPIVIR-HBV are not appropriate for patients dually infected with HBV and HIV.

Epivir side effects

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Common Epivir ide effects may include:

  • See how Hepatitis types A, B and C are trasmitted through issues such as poor hygiene, contamination, sexual contact and more.

  • Special Uses Lamivudine is active against hepatitis B virus, but resistant HBV is observed to emerge over months in the setting of treatment with lamivudine alone.

  • The therapy should be initiated by a physician experienced in the management of HIV infection.

  • Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911.

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including lamivudine and other antiretrovirals. Most of these reports have described patients receiving nucleoside analogues for treatment of HIV infection, but there have been reports of lactic acidosis in patients receiving lamivudine for hepatitis B.

Treatment with EPIVIR or EPIVIR-HBV should be suspended in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity which may include hepatomegaly and steatosis even in the absence of marked transaminase elevations. The formulation and dosage of lamivudine in EPIVIR-HBV are not appropriate for patients dually infected with HBV and HIV.

If a decision is made to administer lamivudine to such patients, the higher dosage indicated for HIV therapy should be used as part of an appropriate combination regimen, and the prescribing information for EPIVIR, COMBIVIR, EPZICOM, or TRIZIVIR as well as for EPIVIR-HBV should be consulted.

More about Epivir

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Where can I get more information?

  • If a child is using this medicine, tell your doctor if the child has any changes in weight.

  • Lamivudine was not genotoxic in vivo at doses that gave plasma concentrations around 40-50 times higher than the anticipated clinical plasma levels.