Generic Name: Epivir
What is Epivir?
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EPIVIR is a nucleoside analogue indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 HIV-1 infection. The recommended dosage of EPIVIR in HIV-1-infected adults is 300 mg daily, administered as either 150 mg taken orally twice daily or 300 mg taken orally once daily with or without food. The recommended dosage of EPIVIR oral solution in HIV-1-infected pediatric patients aged 3 months and older is 4 mg per kg taken orally twice daily or 8 mg per kg taken orally once daily up to a maximum of 300 mg dailyadministered in combination with other antiretroviral agents.
EPIVIR scored tablet is the preferred formulation for HIV-1-infected pediatric patients who weigh at least 14 kg and for whom a solid dosage form is appropriate. Before prescribing EPIVIR scored tablets, pediatric patients should be assessed for the ability to swallow tablets. The recommended oral dosage of EPIVIR tablets for HIV-1-infected pediatric patients is presented in Table 1.
Dosing of EPIVIR is adjusted in accordance with renal function. EPIVIR scored tablets contain 150 mg of lamivudine. EPIVIR tablets contain 300 mg of lamivudine.
How should I take Epivir?
Fact Sheet 404 has more information about guidelines for the use of ART. If you take lamivudine with other ARVs, you can reduce your viral load to extremely low levels, and increase your CD4 cell counts. This should mean staying healthier longer. A different formulation of lamivudine has been approved for people with hepatitis B. Some people with HIV had their hepatitis B get worse after they stopped taking lamivudine.
What should I avoid while taking Epivir?
Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis, kidney problems, liver problems such as hepatitis B or C, cirrhosisalcohol use. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Caution is advised when using this drug in children because they may be more sensitive to the effects of the drug, especially the increased risk of pancreatitis.
Kidney function declines as you grow older. This medication is removed by the kidneys.
Epivir side effects
See the complete prescribing information for EPIVIR Tablets and Oral Solution for additional information on pharmacokinetics of lamivudine in HIV-infected children.
Clinical studies of EPIVIR-HBV did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Frequencies of specified laboratory abnormalities during therapy with EPIVIR-HBV compared with placebo are listed in Table 6. In clinical trials using lamivudine as part of a combination regimen for treatment of HIV infection, several clinical adverse events occurred more often in lamivudine-containing treatment arms than in comparator arms.
Common Epivir ide effects may include:
To reduce the risk of developing drug resistance, all antiretroviral drugs should be taken every day exactly as prescribed and directed.
EPIVIR oral solution has been studied in 638 pediatric subjects aged 3 months to 18 years in 3 clinical trials.
Epivir must be used in combination with other HIV drugs.
M184V mutants display greatly reduced susceptibility to lamivudine and show diminished viral replicative capacity in vitro.
Acest medicament nu trebuie folosit in caz de alergie la Epivir, lamivudina sau la oricare dintre ingredientele continute in Epivir tablete. Discutati cu medicul dumneavoastra despre administrarea Epivir, daca aveti o boala renala sau daca aveti sau ati avut vreodata o afectiune a ficatului. Nu intrerupeti tratamentul cu Epivir fara indicatia medicului, daca descoperiti o boala cronica a ficatului, datorata infectiei cu virus hepatitic B.
Daca sunteti insarcinata sau doriti sa deveniti in curand, sau daca alaptati, va rugam sa informati medicul inainte de a lua orice medicament, inclusiv Epivir. Epivir nu este recomandat in primele 3 luni de sarcina.
Where can I get more information?
The dosage of epivir should be strictly as prescribed by the doctor.
The solution should be measured with a special measuring device or spoon and should not be taken with a household spoon to ensure the correct dosage is administered.