Generic Name: Order enablex
What is Order Enablex?
Clevidipine: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Clomipramine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA. Clonazepam: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including benzodiazepines.
Clonidine: Monoamine oxidase inhibitors MAOIs may interact with antihypertensive medications. Clopidogrel: At high concentrations in vitro, clopidogrel inhibits the activity of CYP2C9. Thus, clopidogrel could increase plasma concentrations of drugs metabolized by this isoenzyme, such as selegiline. Although there are no in vivo data with which to predict the magnitude or clinical significance of this potential interaction, caution should be used when selegiline is coadministered with clopidogrel.
Clorazepate: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including benzodiazepines. Cobicistat: Caution is warranted when cobicistat is administered with selegiline as there is a potential for elevated selegiline concentrations.
Controversies in Neurology: Why Monoamine Oxidase B Inhibitors Could Be a Good Choice for the Initial Treatment of Parkinson's Disease.
BMC Neurology September 2011, 11:112. Muangpaisan W, Mathews A, Hori H, Seidel D. Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease. Basic and Clinical Pharmacology 11th edition. McGraw Hill Companies Inc. Selegeline is a mono amine oxidase inhibitor that has different effects at different doses. It has been used to treat Parkinson's disease since 1986. In 2006, it was approved as an add-on adjunct treatment for Parkinson's sufferers who are already taking levodopa or carbidopa and are no longer responding well to it.
In 2006, a transdermal form of selegiline, EMSAM, was also introduced for treating depression. At low doses 5 mg twice a day selegeline is prescribed to treat Parkinson's disease and senile dementia. At this level, it inhibits mostly MAO-B. At higher doses, selegeline is no longer selective and it inhibits MAO-A and -B, and it is used to treat depression.
Oral high-dose selegiline is helpful in treating atypical depression and symptoms such as overeating, excessive sleeping and extreme sensitivity to rejection by others. EMSAM, the transdermal form of selegeline, is the only transdermal medication used to treat depression.
How should I take Order Enablex?
Desmopressin: Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with SIADH including MAOIs. Use combination with caution, and monitor patients for signs and symptoms of hyponatremia.
Desvenlafaxine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with serotonin norepinephrine reuptake inhibitors SNRIs. MAOIs should not be used within 5 days of discontinuing treatment with duloxetine or within 7 days of discontinuing treatment with other SNRIs. Conversely, SNRIs should not be initiated within 14 days of stopping an MAOI.
Deutetrabenazine: Deutetrabenazine use is contraindicated in patients who are receiving or have received MAOI therapy within the past 14 days. Inhibition of VMAT2 results in decreased uptake of monoamines into synaptic vesicles and depletion of monoamine stores. Diazepam: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including benzodiazepines.
What should I avoid while taking Order Enablex?
Serum glucose should be monitored closely when MAOIs are added to any regimen containing antidiabetic agents. Inhibitors of MAO type A have been shown to prolong the hypoglycemic response to insulin and oral sulfonylureas. Serum glucose should be monitored closely when MAOI-type medications, including the selective MAO-B inhibitor selegiline, are added to any regimen containing antidiabetic agents.
Inhibitors of MAO type A have been shown to prolong the hypoglycemic response to insulin and other antidiabetic agents. Alpha-blockers: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Careful monitoring of blood pressure is suggested during concurrent therapy with antihypertensives such as alpha-blockers.
Order Enablex side effects
Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking selegiline. Avoid foods and beverages that are high in tyramine, including: aged cheeses e. Limit or avoid foods that are moderate in tyramine, including: avocados, bananas, eggplant, green beans, raisins, raspberries, red plums, spinach, tomatoes, chocolate, cultured dairy products e. Consult your doctor or dietician for more details and a complete list of other tyramine-containing foods you should limit or avoid.
Make sure laboratory personnel and all your doctors know you use this drug. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
Common Order Enablex ide effects may include:
Calcium-channel blockers: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
Some of these effects have been reported with the use of phenelzine alone.
First-pass quantitative CT perfusion identifies thresholds in compensation salvageable penumbra in severe the value of CBF and cerebral metabolic monitoring, in function because an settlement of the relationships between miscellaneous monitored parameters should allow earlier identi- fication of altered pathophysiology and thus produce a wider corrective window to butt therapy preceding the time when irreversible injury occurs.
Serotonin syndrome has been reported when linezolid has been administerd with certain serotonergic agents.
The precise dose at which selegiline becomes a non-selective inhibitor of all MAO is unknown, but may be in the range of 30 to 40 mg a day. Severe CNS toxicity associated with hyperpyrexia and death have been reported with the combination of tricyclic antidepressants and non-selective MAOIs NARDIL, PARNATE. A similar reaction has been reported for a patient on amitriptyline and ELDEPRYL. Another patient receiving protriptyline and ELDEPRYL developed tremors, agitation, and restlessness followed by unresponsiveness and death two weeks after ELDEPRYL was added.
Where can I get more information?
Canagliflozin: Animal data indicate that monoamine oxidase inhibitors MAOIs may stimulate insulin secretion.
Side effects Generic Eldepryl has its side effects.