Generic Name: Generic enablex
What is Generic Enablex?
Angiotensin II receptor antagonists: Additive hypotensive effects may be seen when selegiline is combined with angiotensin II receptor antagonists. Angiotensin-converting enzyme inhibitors: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. A dose reduction of one or both medications may be required. Apraclonidine: Apraclonidine is contraindicated for use in patients receiving MAOIs. Apraclonidine should not be administered to patients who have received MAOIs within the previous 14 days.
Aprepitant, Fosaprepitant: Use caution if selegiline and aprepitant, fosaprepitant are used concurrently, and monitor for an increase in selegiline-related adverse effects for several days after administration of a multi-day aprepitant regimen.
Selegiline is a CYP3A4 substrate in vitro. For example, a 5-day oral aprepitant regimen increased the AUC of another CYP3A4 substrate, midazolam single doseby 2.
As a single 125 mg or 40 mg oral dose, the inhibitory effect of aprepitant on CYP3A4 is weak, with the AUC of midazolam increased by 1. Aprepitant is also a CYP2C9 inducer and selegiline is a CYP2C9 substrate in vitro.
Selegiline Overdosage Some patients exposed to doses of 600 mg of d,l-Selegiline suffered severe hypotension and psychomotor agitation. Warnings And Precautions Below are the warnings and precautions when undergoing treatment with Selegiline tablets. May cause hypertension above 2. Nursing Considerations It is not known whether Selegiline HCl is excreted in human milk. What here your facility to accomplish safely when you are padding in representing someone who is not there.
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How should I take Generic Enablex?
Patients should avoid the use of dextromethorphan-containing medications during MAOI use and for 2 weeks following MAOI discontinuation. Selective inhibitors of MAO-B e. Also, potentiation of the effects of the MAOI have been reported, which may increase the risk for adverse events. If combination therapy is necessary, advise patients against driving or performing other hazardous activities until they know how the combination affects them.
Prior to concurrent use of oxycodone in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient's overall response to treatment.
What should I avoid while taking Generic Enablex?
Associations not recommended Oral contraceptives The combination of selegiline and oral contraceptives or drugs for hormone replacement therapy, should be avoided, as this combination may increase the bioavailability of selegiline. Selegiline is indicated for the treatment of Parkinson's disease which, in most cases, is a disease occurring after childbearing age.
Pregnancy Studies in animals have shown reproductive toxicity only at high multiple of human doses. Even when used correctly, this medicine may cause dizziness or can affect reaction capacity to the extent that driving or operating machinery is affected and therefore patients should be advised not to drive or use machines if they experience these adverse reactions during treatment.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Selegiline is rapidly metabolised and the metabolites rapidly excreted. Pharmacotherapeutic group: Monoamine oxidase B inhibitors, ATC-code: N04BD01Selegiline is a selective MAO-B-inhibitor which prevents dopamine breakdown in the brain.
Generic Enablex side effects
Selegiline orally disintegrating tablets should be used cautiously in patients with phenylketonuria. Each selegiline orally disintegrating tablet Zelapar contains 1. Patients taking the 2. Advise patients that selegiline orally disintegrating tablets contains aspartame which could cause problems in patients with phenylketonuria. The effect of direct heat applied to the selegiline transdermal patch on the bioavailability of selegiline has not been studied.
Common Generic Enablex ide effects may include:
Hypotension and vascular collapse should be treated with intravenous fluids and, if necessary, blood pressure titration with an intravenous infusion of a dilute pressor agent.
Advise patients against driving or performing other tasks requiring alertness until they know how the combination affects them.
Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that selegiline transdermal therapy does not impair their ability to engage in such activities.
Associations not recommendedThe combination of selegiline and oral contraceptives or drugs for hormone replacement therapy, should be avoided, as this combination may increase the bioavailability of selegiline.
After IV administration, the half-lives of selegiline and its 3 metabolites N-desmethylselegiline, L-amphetamine, and L-methamphetamine ranged from 18 to 25 hours. Following hepatic metabolism, selegiline is excreted primarily in the urine as metabolites mainly as L-methamphetamine and L-amphetamine and as a small amount in the feces. In vitro studies indicate that CYP2B6, CYP2C9, CYP3A4 and CYP3A5 appear to be the major isoenzymes involved in the formation of L-methamphetamine from selegiline, with CYP2A6 having a minor role.
CYP2A6, CYP2B6, CYP3A4 and CYP3A5 appear to contribute to the formation of L-amphetamine from N-desmethylselegiline.
Where can I get more information?
Nortriptyline: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA.
These effects do not appear to be due to MAO activity, but rather, a change in gluconeogenesis or insulin sensitivity related to a hydrazine chemical structure.