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Monoamine oxidase, MAO and COMT are the two major enzymes involved in the metabolism of catecholamines. It may be prudent to avoid the combination of green tea and monoamine oxidase inhibitors. As is recommended with other COMT inhibitors, 14 days should lapse between the discontinuation of nonselective MAOIs and the use of green tea.
Dangerous cardiac arrhythmias or severe hypertension can occur because of the potentiation of caffeine's sympathomimetic effects by MAOIs. Caffeine use should be minimized or avoided during and for 12 weeks after discontinuation of any MAOI. Guanabenz: Guanabenz withdrawal can result in an increase in serum catecholamine levels.
Thus, drugs that alter the metabolism or uptake of catecholamines, such as monoamine oxidase inhibitors MAOIs should be used cautiously in patients who are undergoing guanabenz withdrawal. Guanfacine: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Guarana: Caffeine, an active constituent of guarana, interacts with MAOIs including drugs with MAOI activity such as furazolidone, isoniazid, INH, linezolid, procarbazine, and high doses of yohimbine.
Guarana should be avoided during and for 1 to 2 weeks after discontinuation of any MAOI. Halothane: Patients taking MAOIs should not undergo elective surgery, including dental procedures, that require the use of general anesthetics due to the potential for CNS and cardiovascular reactions. Hydantoins: MAOIs can cause a variable change in seizure patterns, so careful monitoring of the patient with epilepsy is required.
How would you like a stronger immune system or better sleep. HOW TO USE: Take this medication by mouth, usually twice daily with breakfast and lunch. The usual highest dose is 5 milligrams twice a day. You are encouraged to report negative side effects of prescription drugs to the FDA.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else.
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Special care should be taken when administering selegiline to patients who have labile hypertension, cardiac arrhythmias, severe angina pectoris, psychosis or a history of peptic ulceration as aggravation of these conditions may occur during treatment.
Although serious hepatic toxicity has not been observed, caution is recommended in patients with a history of hepatic dysfunction. Transient or continuing abnormalities with a tendency for elevated plasma concentrations of liver enzymes have been described during long-term therapy with conventional tablets of selegiline.
MAO inhibitors, including selegiline, may potentiate the effects of CNS depressants used for general anaesthesia. Since selegiline potentiates the effects of levodopa, the adverse effects of levodopa may be increased. When selegiline is added to the maximum tolerated dose of levodopa, involuntary movements and agitation may occur.
When an optimum dose of levodopa is reached, adverse effects from the combination are less than those observed with levodopa on its own.
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Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. Medicines and their possible side effects can affect individual people in different ways.
The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
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Valerian, Valeriana officinalis: Any substances that act on the CNS may theoretically interact with valerian, Valeriana officinalis. Valproic Acid, Divalproex Sodium: Concomitant use of CNS depressants with valproic acid can cause additive CNS depression.
MAOIs, used concomitantly with valproic acid, can increase CNS depression and also can lower the seizure threshold, requiring change in the valproic acid dose. Valsartan: Additive hypotensive effects may be seen when selegiline is combined with angiotensin II receptor antagonists. Vasodilators: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives or medications with hypotensive properties.
Venlafaxine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with serotonin norepinephrine reuptake inhibitors SNRIs. Verapamil: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
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Captopril: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
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BMC Neurology September 2011, 11:112. Muangpaisan W, Mathews A, Hori H, Seidel D. Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease.
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Flurazepam: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including benzodiazepines.
Careful monitoring of blood pressure is suggested during concurrent therapy of MAOIs with angiotensin-converting enzyme inhibitors ACE inhibitors.