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Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. See also Side Effects section. To minimize dizziness and the risk of fainting, get up slowly when rising from a sitting or lying position.

Before having surgery, tell your doctor or dentist you are taking this medication. You may need to stop taking this drug beforehand. Follow your doctor's instructions carefully. Selegiline should be used only when clearly needed during pregnancy. Tell your doctor or pharmacist if you are using any of these medications before, during, or within 2 weeks after treatment with selegiline.

Tell your doctor or pharmacist if you have taken fluoxetine during at least 5 weeks before starting selegiline.

The manufacturer recommends that medicines containing oestrogens or progestogens eg contraceptives and HRTshould be avoided in people taking selegiline, because these hormones may increase the blood level of selegiline and thus increase the risk of its side effects. The manufacturer recommends that nasal decongestants such as ephedrine and pseudoephedrine should be avoided by people taking this medicine, because the combination may risk causing a hypertensive crisis.

The manufacturer also recommends that the following medicines are avoided by people taking selegiline:Selegiline tablets are also available without a brand name, ie as the generic medicine. The web site does not have answers to all problems. Answers to specific problems may not apply to everyone.

Eldepryl tablets and syrup contain the active ingredient selegiline, which is a type of medicine called a selective monoamine-oxidase-B inhibitor. Side effects to look out for, if you can drink or drive, when you might need extra monitoring and if it's safe while pregnant or. With or without food. What if you forget a dose. What if I forget a dose of pregabalin. Find out if it's OK to take other painkillers or drugs while you're taking pregabalin By Rita Ghelani Medication and elderly people Be informed.

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Amoxapine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with heterocyclic antidepressants e. Conversely, heterocyclic antidepressants should not be initiated within 14 days of stopping an MAOI. The manufacturer of rasagiline does not contraindicate the combination but recommends avoiding use of antidepressants with rasagiline or within 14 days of discontinuing rasagiline.

Anagrelide: Anagrelide has been shown to inhibit CYP1A2. In theory, coadministration of anagrelide with substrates of CYP1A2, including selegiline, could lead to increases in the serum concentration of selegiline and thus, adverse effects.

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Coadministration of teriflunomide with CYP1A2 substrates, such as selegiline, may decrease selegiline exposure and lead to efficacy reduction.

If teriflunomide is discontinued in a patient taking selegiline, serum concentrations may increase. Monitor patients for increases in adverse effects, such as dyskinesia, hallucinations, or nausea. Dose adjustments may be required.

Tetrabenazine: Tetrabenazine depletes presynaptic dopamine, norepinephrine, and serotonin storage and antagonizes postsynaptic dopamine receptors.

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Use caution when administering these drugs concomitantly. Penbutolol: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.

Pentobarbital: MAOIs may prolong the effect of pentobarbital and cause additive CNS depression. Perampanel: Co-administration of perampanel with CNS depressants, including ethanol, may increase CNS depression. Perindopril: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.

Perphenazine: Concurrent use of MAOIs and phenothiazines may prolong or intensify the hypotensive, anticholinergic, or sedative effects of either agent.

Concurrent use of MAOIs and phenothiazines may prolong or intensify the hypotensive, anticholinergic, or sedative effects of either agent. Phenobarbital: MAOIs may prolong the effect of phenobarbital and cause additive CNS depression.

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  • The most frequently seen side effect is a skin reaction to the transdermal patch with EMSAM.

  • Buprenorphine: Concurrent use of opioids with other drugs that modulate serotonergic function, such as monoamine oxidase inhibitors MAOIshas resulted in serotonin syndrome in some cases.

  • Those who have experienced somnolence or a sudden episode of sleep with the drug should avoid these activities.

  • Selegiline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Tricyclic antidepressants: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA.

Trifluoperazine: Concurrent use of MAOIs and phenothiazines may prolong or intensify the hypotensive, anticholinergic, or sedative effects of either agent. Trimipramine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA. Trospium: MAOIs exhibit secondary anticholinergic actions.

Additive anticholinergic effects may be seen when MAOIs are used concomitantly with antimuscarinics such as trospium.

Where can I get more information?

  • Your doctor will normally start you on a dose of 10 mg Eldepryl each day.

  • However, transdermal dosing results in significantly higher exposure to selegiline with significantly lower exposure for all metabolites relative to oral administration.