Generic Name: Generic emflaza
What is Generic Emflaza?
The combination or rapid succession of MAOI treatment could result in severe CNS or cardiovascular reactions, including hypertensive crises, hyperpyrexia, CNS excitation, delirium, tremor, convulsions, coma, circulatory collapse or death.
At least 14 days should elapse between the discontinuation of rasagiline and the initiation of another MAOI or the discontinuation of another MAOI and the initiation of rasagiline. Remifentanil: Remifentanil use is not recommended in patients who are receiving or who have received monoamine oxidase inhibitors MAOIs within the previous 14 days.
Concomitant use of remifentanil with other serotonergic drugs such as MAOIs may result in serious adverse effects including serotonin syndrome. MAOIs may cause additive CNS depression, respiratory depression, drowsiness, dizziness, or hypotension when used with opiate agonists such as remifentanil.
If urgent use is necessary, use test doses of remifentanil with frequent titration of small doses and close monitoring. Repaglinide: Inhibitors of MAO type A have been shown to prolong the hypoglycemic response to antidiabetic agents. Reserpine: The concomitant use of reserpine and monoamine oxidase inhibitors MAOIs is contraindicated.
Acutely, reserpine can increase the risk of hypertensive crisis by causing an initial release of catecholamines from bound stores.
Katzung, 2009 How many people have Parkinsonism. When decreased in levels in Parkinsonism, the effects of excitatory neurotransmitters will continue and will lead to the distinct features in motor and neuropsychiatric symptoms. To relieve from these symptoms, an enzyme called monoamine oxidase MAO can be irreversibly inhibited. Monoamine oxidase is medically proven to be responsible for the destruction of most of the dopamine after it has been secreted from the neurons in the basal ganglia.
These two forms, MAO-A and MAO-B, had been differentiated by their sensitivity to a certain MAO inhibitor clorgyline. MAO-A is inhibited by low doses of clorgyline, whereas MAO-B is relatively insensitive to clorgyline inhibition. Drugs that inhibit MAO-A are at more risk for dietary tyramine-provoked hypertensive crisis because its metabolites, amphetamine and metamphetamine, can inhibit peripheral MAO-A mostly found in the liver, kidney, stomach and small intestines which is essential for tyramine metabolism.
Theoretically, Eldepryl only inhibits MAO-B that is only found in the brain but it can also possibly inhibit MAO-A at large doses. However, control in food intake rich in tyramine, such as pickled, smoked or fermented meat and cheese, is still advised.
Recent studies had failed to prove this syndrome at prescribed doses of Eldepryl but given the higher specificity of a second-generation MAO-B inhibitor RasagilineEldepryl has a higher likelihood of causing the said syndrome than the latter, Barrett, 1996 How does the body react to Eldepryl intake.
Eldepryl is a drug with low bioavailabilty and should be taken with a meal, most preferably rich in fat. It is taken orally in tablet form and is currently available in two doses 5mg, 10mg. For early parkinsonism, it is usually taken 10 mg daily in single or divided doses, preferably during breakfast and lunch because it causes insomnia when taken at night. Free forms were also found in the urine but in minimum amount.
Special precautions on this drug should also be done in patients with uncontrolled hypertension and other cardiovascular diseases.
How should I take Generic Emflaza?
If serotonin syndrome is suspected, discontinue dolasetron and concurrent serotonergic agents and initiate appropriate medical treatment. Serotonin syndrome is characterized by rapid development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes e. Doxazosin: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
Doxepin: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA.
Dronabinol, THC: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including dronabinol.
Droperidol: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including droperidol. Following administration of droperidol, lower doses of the other CNS depressant should be used. Duloxetine: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with serotonin norepinephrine reuptake inhibitors SNRIs.
What should I avoid while taking Generic Emflaza?
Selegiline should not be started until 2 weeks after stopping sertraline. For all other serotonin reuptake inhibitors, a time interval of 1 week is recommended between discontinuation of the serotonin reuptake inhibitor and initiation of selegiline.
In general, selegiline should not be introduced after a drug that is known to interact with selegiline, until after 5 half lives of that drug have elapsed. At least 14 days should lapse between the discontinuation of selegiline and initiation of treatment with any drug known to interact with selegiline. A time interval of 24 hours is recommended between the discontinuation of selegiline and initiation of serotonin agonists. Patients being treated with selegiline currently or within the past 2 weeks should receive dopamine only after careful risk-benefit assessment, as this combination enhances the risk of hypertensive reactions.
Associations not recommendedThe combination of selegiline and oral contraceptives or drugs for hormone replacement therapy, should be avoided, as this combination may increase the bioavailability of selegiline.
Generic Emflaza side effects
This action may be additive with other agents that can cause hypotension such as antidepressants. Patients should be monitored more closely for hypotension if nitroglycerin is used concurrently with antidepressants. Nitroprusside: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives or medications with hypotensive properties.
Non-Ionic Contrast Media: Use of medications that lower the seizure threshold, such as monoamine oxidase inhibitors, should be carefully evaluated when considering intrathecal radiopaque contrast agents. Nortriptyline: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA.
Olaparib: Use caution if coadministration of olaparib with selegiline is necessary, due to the risk of decreased efficacy of selegiline. Olaparib is a CYP2B6 inducer in vitro, and selegiline is a CYP2B6 substrate in vitro. Concomitant use may result in decreased selegiline exposure.
Common Generic Emflaza ide effects may include:
Nateglinide: Inhibitors of MAO type A have been shown to prolong the hypoglycemic response to antidiabetic agents.
Follow your doctor's instructions carefully.
Pregnancy: Jumex has not been studied in pregnant women.
It is unknown if selegiline is excreted into human breast milk, and a decision should be made whether to discontinue the drug or discontinue breast-feeding, taking into account the importance of the drug to the mother.
The manufacturer recommends that nasal decongestants such as ephedrine and pseudoephedrine should be avoided by people taking this medicine, because the combination may risk causing a hypertensive crisis.
The manufacturer also recommends that the following medicines are avoided by people taking selegiline:Selegiline tablets are also available without a brand name, ie as the generic medicine.
The web site does not have answers to all problems.
Where can I get more information?
So if I were to low dose selegiline at 3mg 2x daily and figure out a good dose for MB, I could gain all the goods of both.
Absorption Selegiline HCl is readily absorbed from the gastrointestinal tract.