Generic Name: Eldepryl
What is Eldepryl?
Concomitant administration of amantadine and anticholinergic drugs can lead to an increased occurrence of side-effects. Four patients receiving altretamine and a monamine oxidase inhibitor experienced symptomatic hypotension after four to seven days of concomitant therapy. Concomitant use of hypertensive agents, antihypertensives, psychostimulants, central suppressant drugs sedatives, hypnotics and alcohol should be avoided. The available safety data concerning the use during pregnancy and lactation is insufficient to justify the use of selegiline in these patient groups.
PregnancyStudies in animals have shown reproductive toxicity only at high multiple of human doses. This medicine can impair cognitive function and can affect a patient's ability to drive safely. This class of medicine is in the list of drugs included in regulations under 5a of the Road Traffic Act 1988. They are listed below as MedDRA preferred term by system organ class and frequency.
As selegiline potentiates the effect of levodopa levodopa should be usually given in association with a peripheral decarboxylase inhibitorthe side-effects of levodopa may be emphasised unless the dosage of levodopa is reduced. Once the optimum levodopa dose level has been established, the side-effects produced by the combination will usually be less than those caused by the levodopa therapy on its own.
Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme at: www.
Selegiline is used together with other medicines to treat symptoms of Parkinson's disease. Selegiline may also be used for other purposes not listed in this medication guide. You should become very familiar with the list of foods to avoid while you are using selegiline. Next Page:What should I discuss with my healthcare provider before using selegiline Eldepryl, Zelapar.
Anyone considering using it for MDD in a child or adolescent must balance risk with clinical need, as depression itself increases suicide risk. With patient of any age, observe closely for clinical worsening, suicidality, and unusual behavior changes when therapy begins.
John's wort without consulting with prescriber. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
AvailabilityCapsules: 5 mgTablets: 5 mgTablets orally disintegrating : 1. Adverse reactionsCNS: agitation, anxiety, bradykinesia, chorea, confusion, delusions, depression, dizziness, hallucinations, headache, dyskinesias, increased akinetic involuntary movements, insomnia, lethargy, light-headedness, loss of balance, syncope, vivid dreamsCV: orthostatic hypotension, hypertension, new or increased angina, palpitations, arrhythmiasGI: nausea, diarrhea, abdominal pain, dry mouth, buccal mucosa irritation with orally disintegrating tablets GU: urinary retentionMusculoskeletal: leg pain, low back painOther: generalized aches, weight lossInteractionsDrug-drug.
Adrenergics: increased pressor responseBuspirone: elevated blood pressureDextromethorphan: brief episodes of psychosis or bizarre behaviorLevodopa: increased adverse reactions to levodopaMeperidine and analgesics such as tramadol, methadone, and propoxyphene: stupor, muscle rigidity, severe agitation, fever, deathOther MAO inhibitors: hypertensive crisisSSRIs Some helpful signs in the fight against Parkinson's diseaseGoodman, who voted for approval with no dietary restrictions for the 20-mg dose, said he saw no signal of harmful effects of the 20-mg patch in clinical safety data presented by the manufacturer and in the more extensive database on Eldepryl.
PARKINSON'S DISEASE--THE SEARCH FOR GENETIC CLUESArtane, Kemadrin, Benadryl, Atkineton, Parlodel, Permax, Eldepryl Antianxiety and Hypnotic Agents - Librium, Valium, Dalmane,Managing disruptive behavioral symptoms: today's do's and don't'sIn another study of oral Eldepryl for treating parkinsonism in 800 patients, with 2,970 patient years of exposure, mortality among those on selegiline 2.
How should I take Eldepryl?
This drug is available at a higher level co-pay. Prior Authorization Drugs that require prior authorization. Quantity Limits Drugs that have quantity limits associated with each prescription.
Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
What should I avoid while taking Eldepryl?
Promethazine: The concurrent use of MAOIs with sedating H1-blockers is not recommended because of an increase in the intensity and prolongation of CNS-depressant and anticholinergic effects. Propofol: Patients taking MAOIs should not undergo elective surgery, including dental procedures, that require the use of general anesthetics due to the potential for CNS and cardiovascular reactions. Propoxyphene: Concurrent use of selegiline or selegiline, transdermal and propoxyphene is contraindicated.
Propranolol: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Protriptyline: Due to the risk of serotonin syndrome, monoamine oxidase inhibitors MAOIs intended to treat psychiatric disorders are contraindicated for use with tricyclic antidepressants TCAs or within 14 days of discontinuing treatment with a TCA.
Quazepam: The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including benzodiazepines. Quinapril: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
Eldepryl side effects
Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking ELDEPRYL. No specific laboratory tests are deemed essential for the management of patients on ELDEPRYL. Periodic routine evaluation of all patients, however, is appropriate. The occurrence of stupor, muscular rigidity, severe agitation, and elevated temperature has been reported in some patients receiving the combination of selegiline and meperidine. Symptoms usually resolve over days when the combination is discontinued.
This is typical of the interaction of meperidine and MAOIs. Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and ELDEPRYL and selective serotonin re-uptake inhibitors and ELDEPRYL. One case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medication ephedrine.
Common Eldepryl ide effects may include:
Potassium-sparing diuretics: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
Linagliptin: Animal data indicate that monoamine oxidase inhibitors MAOIs may stimulate insulin secretion.
In any case, up-to-date information about the treatment of overdose can often be obtained from a certified Regional Poison Control Center.
Sumatriptan: Serotonin syndrome has been reported during co-administration of serotonin-receptor agonists and monoamine oxidase inhibitors MAOIs.
What if I forget a dose of pregabalin. Find out if it's OK to take other painkillers or drugs while you're taking pregabalin By Rita Ghelani Medication and elderly people Be informed. Eldepryl, generic name selegiline known in Europe under brand name Jumex protects against aging of the brain and enhances mental function. A powerful remedy against Parkinson's disease, Eldepryl is effective also as an antidepressant and as a protector against Alzheimer's disease.
Where can I get more information?
In vitro studies indicate that CYP2B6, CYP2C9, CYP3A4 and CYP3A5 appear to be the major isoenzymes involved in the formation of L-methamphetamine from selegiline, with CYP2A6 having a minor role.
Due to the potential for additive CNS and cardiovascular effects, MAOIs and thiothixene should be used together cautiously.