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It also inhibits the reuptake of dopamine at the presynaptic dopamine receptor. These effects potentiate dopaminergic function in the brain and help to even out and prolong the effect of exogenous and endogenous dopamine.
Thus, selegiline potentiates and prolongs the effect of levodopa in the treatment of parkinsonism. Double-blind studies on early phase Parkinsonian patients showed that patients receiving selegiline monotherapy manage significantly longer without levodopa therapy than controls receiving placebo.
These patients could also maintain their ability to work longer. The addition of selegiline to levodopa with or without decarboxylase inhibitor therapy helps to alleviate dose related fluctuations and end of dose deterioration. Unlike conventional MAO-inhibitors, which inhibit both the MAO-A and MAO-B enzyme, selegiline is a specific MAO-B inhibitor and can be given safely with levodopa. Selegiline does not cause the so called "cheese effect" either when used alone as monotherapy, or when used with other drugs, except for moclobemide or nonselective MAO-inhibitors.
The maximal concentrations are reached in 0.
That may get me some of the missing links that selegiline doesn't give me. I'm hoping some people will chime in on their selegiline usage, and what they're stacking along with it. Posted 29 September 2011 - 09:05 PM Posted 29 September 2011 - 09:13 PM Posted 30 September 2011 - 06:37 PM Posted 30 September 2011 - 11:43 PM Posted 01 October 2011 - 09:37 PMAlright, the backstory of my usage, as i can reverse engineer it now, is as such: I found the Selegiline allowed me to switch from one task to the next with less effort.
I didn't notice it while I was using it, but when I stopped oooh man if I pulled my head out of one task I would be completely retarded in the next task which should have come natural and quickly.
It allows me to "hyperfocus" which is basically just a way that my brain refuses to switch to another task. I found that the Selegiline reduced that a bit. But after the 3 days without it I was hit with a surge of motivation and creativity.
I was also unable to switch from one task to another very easily. I would say that has always been my trouble spot is to use my "fluid intelligence" properly so as to transfer from one thing to another. I'd like to think what I got from ID was legit, but. Once I get a chance I'll pick up some from IAS whoever that isand recount my experiences once again.
I noticed that the Selegiline I had didn't have the benefits I had expected. I mentioned in another post on here or somewhere else that I'd like to get a source that's confirmed so I can be sure of its effects and judge for myself if it's worth it.
Money is of some concern, but not especially important. But I think at smaller doses it has MAO-B selectivity, and with higher doses it loses that and also becomes MAO-A inhibitor in addition to the MAO-B.
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Advise patients against driving or performing other hazardous activities after receiving alfentanil. Aliskiren: Orthostatic hypotension has been reported during administration of selegiline. Therefore, caution is advised during concurrent use with antihypertensive agents. Careful monitoring of blood pressure is suggested during concurrent therapy of MAOIs with calcium-channel blockers.
Orthostatic hypotension has been reported during administration of selegiline.
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Use of epinephrine added to chloroprocaine with monoamine oxidase inhibitors MAOIs or drugs with MAOI activity e. Chlorothiazide: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Chlorpromazine: Concurrent use of MAOIs and phenothiazines may prolong or intensify the hypotensive, anticholinergic, or sedative effects of either agent.
Due to the potential for additive CNS and cardiovascular effects, MAOIs and phenothiazines should be used together cautiously. Chlorthalidone: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
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What ELDEPRYL is used for ELDEPRYL tablets are used to treat the symptoms of Parkinson's disease. This is a disease of the brain that affects movement. People with Parkinson's disease do not have enough nerve cells in the part of the brain that controls movement. Before you take it When you must not take it Do not take ELDEPRYL tablets if: 1. If you take this medicine after the date has passed it may have no effect at all, or worse, an entirely unexpected effect. If you have not told your doctor about any of the above, tell them before you start taking ELDEPRYL tablets.
Swallow the prescribed dose of this medicine with a large glass of water while standing upright.
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In case you need to stop the medication, consult your doctor.
Azilsartan: Additive hypotensive effects may be seen when selegiline is combined with angiotensin II receptor antagonists.
Selegiline should not be used in combination with levodopa in any of the following conditions:This medicine should not be used if you are allergic to one or any of its ingredients.
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At least 7 days should elapse between discontinuation of carbamazepine and initiation of an MAOI. MAOIs should be discontinued for a minimum of 14 days or longer if the clinical situation permits, before administering carbamazepine. When starting MAOI therapy after discontinuing carbamazepine, isocarboxazid should be initiated at one-half the normal starting dosage for at least the first week of therapy.
Where can I get more information?
Caution is advised when selegiline is taken in combination with other centrally acting medicinal products and substances.
If selegiline dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment.