Generic Name: Efavirenz
What is Efavirenz?
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Explore Research LabsFind Clinical TrialsResearch FacultyPostdoctoral FellowshipsDiscovery's Edge MagazineSearch PublicationsTraining Grant PositionsResearch and Clinical TrialsSee how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care.
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See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information. Some side effects of efavirenz can be serious. Serious side effects of efavirenz include serious mental health problems, liver problems, and severe rash. See the WARNING box above. Tell your health care provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of efavirenz.
To learn more about possible side effects of efavirenz, read the drug label or package insert or talk to your health care provider or pharmacist.
Do not use efavirenz if the original seal over the container opening is broken or missing. Throw away efavirenz that is no longer needed or expired out of date. Follow FDA guidelines on how to safely dispose of unused medicine. What should I tell my health care provider before taking efavirenz. How should I take efavirenz. What should I do if I forget a dose.
How should I take Efavirenz?
This practice is used by developed countries such as Italy and Canada, as well as by developing countries, for pharmaceutical products. In the case of antiretroviral drugs, Mozambique, Malaysia, Indonesia, and Thailand have made use of this legal device. In Brazil, compulsory licensing may be implemented based on circumstances described in the Brazilian Industrial Property Law, such as the abuse of civil rights, abuse of economic power, local non-development, unsatisfactory commercialization, national emergency, and public interest.
Mr M is a 32-year old, HIV-positive patient who was initiated on ART fixed dose combination tenofovir 300 mg, emtricitabine 200 mg and efavirenz 600 mg on 16 September 2014. One week into treatment, he developed a generalised maculopapular skin rash with no mucosal involvement or systemic symptoms.
What should I avoid while taking Efavirenz?
Liver problems can happen in people without a history of liver problems. Seizures can happen in people who take SUSTIVA. Seizures are more likely to happen if you have had them in the past. Changes in your immune system can happen when you start taking HIV medicines. Tell your doctor if you start having new symptoms after starting your HIV medicine.
Efavirenz side effects
The following drugs interact or have the potential to interact with efavirenz. Examples of these medicines include cyclosporine Neoral, Sandimmunesirolimus Rapamune and tacrolimus Prograf Resistance, cross-resistance and treatment interruption Over time, as new copies of HIV are made in the body, the virus changes its structure.
Dosage and formulations Efavirenz is available as 600 mg tablets and 50 mg, 100 mg and 200 mg capsules. Availability Efavirenz is licensed in Canada for the treatment of HIV infection in adults, in combination with other anti-HIV drugs.
References Mollan KR, Smurzynski M, Eron JJ, et al. Efavirenz can be taken in a single dose and has potent anti-HIV activity when used as part of combination therapy commonly called ART or HAART in many studies.
Common Efavirenz ide effects may include:
Buy a small pill box so that you can carry a dose or two of your medicines with you in case you are away from home.
For more information on how to take efavirenz, see the FDA drug label from DailyMed.
Most commonly, these are "preferred" on formulary brand drugs.
Another study28 set in Cape Town showed only 12.
Pediatric Patients Study AI266922 is an open-label study to evaluate the pharmacokinetics, safety, tolerability, and antiviral activity of SUSTIVA in combination with didanosine and emtricitabine in antiretroviral-naive and -experienced pediatric patients.
When used with other antiretroviral medicines to treat HIV-1 infection, SUSTIVA may help: reduce the amount of HIV-1 in your blood. This is called viral load.
Avoid doing things that can spread HIV-1 infection to others: Do not share or reuse needles or other injection equipment.
Where can I get more information?
Your baby could have birth defects if you take efavirenz in the first trimester.
Relative risks of congenital anomalies comparing women exposed to efavirenz and nonefavirenz-based antiretroviral regimens were pooled using random effects meta-analysis.