Efavirenz

Generic Name: Efavirenz

What is Efavirenz?

Since these specific dose amounts are not achievable with existing market formulations, simulated exposures for EFV daily doses of 300 mg, 450 mg, and 600 mg are presented in Table 5 to reflect similar doses that are achievable with the currently existing formulations. Mean SD change from baseline CD4 counts at days 84, 168 and after 200 days of EFV based ART was 93. AUC values for these 6 patients, as well as their baseline and day 84 HIV RNA values are presented in Table 6. In part this may be because the pharmacodynamics response is so strong for most patients at all observed exposure levels on this combination HAART therapy.

Despite the existing evidence of extensive inter-ethnic EFV pharmacokinetic variability that is dependent on host-genetic-factors, its dosing in the sub-Saharan African region is to date based largely on data derived from studies conducted among Caucasians. We predicted EFV optimal dose for adult HIV-1 infected Ugandans based upon population genetic make-up and recommend a dose reduction from 600 mg to 450 mg daily dose.

Presumably the supra-therapeutic EFV exposure might play a role in adherence issues and consequent treatment outcomes of EFV based ART. Successful HIV viral suppression has been demonstrated at EFV doses of 400 mg and 200 mg daily among patients that exhibited supra-therapeutic plasma concentrations following 600 mg daily EFV dose.

The current study had a long follow up period of up to 252 days and pharmacokinetic data were collected at assumed steady state conditions.

Your doctor will test for these changes. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, website www.

By reporting side effects you can help provide more information on the safety of this medicine. Do not use this medicine after the expiry date which is stated on the bottle or blister and on the carton after EXP. Reddy's Laboratories UK Ltd Contact details Summary of Product Characteristics print PIL this link will open a new window Bookmark This Medicine check related medicine report side effect Efavirenz 600 mg Film-Coated Tablets SPC Sign up to bookmark this PIL already have an account.

Log in Find medicines with the same active ingredients Find medicines from the same company Download Patient Information Leaflet Having problems opening this PDF. Download Acrobat Reader The Patient Information Leaflet PIL is the leaflet included in the pack with a medicine. What is in this leaflet 1. Contents of the pack and other information 1.

What Efavirenz 600 mg is and what it is used for Efavirenz 600 mg Film-coated tablets, which contains the active substance efavirenz, belongs to a class of antiretroviral medicines called non-nucleoside reverse transcriptase inhibitors NNRTIs. What you need to know before you take Efavirenz 600 mg Do not take Efavirenz 600 mg: if you are allergic to efavirenz or any of the other ingredients of this medicine listed in section 6.

How should I take Efavirenz?

If you miss doses or stop taking efavirenz, your condition may become more difficult to treat. Efavirenz is also used with other medications to help prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the possible risks of using this medication for your condition.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What should I avoid while taking Efavirenz?

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Efavirenz side effects

SustivaIs efavirenz available as a generic drug. GENERIC AVAILABLE: NoDo I need a prescription for efavirenz. YesWhat are the side effects of efavirenz. The most common side effects of efavirenz are: rash, dizziness, confusion, insomnia, headaches, diarrhea, nausea, and vomiting. Other side effects include muscle pain myalgiaabnormal heartbeats, liver failure, increased cholesterol increased triglyceride levels.

Quick GuideHIV AIDS Facts: Symptoms and Treatments Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. See more info: efavirenz on RxList PREV 12 3 4 NEXT Need help identifying pills and medications.

Common Efavirenz ide effects may include:

  • View ArticlePubMedGoogle ScholarSaitoh A, Hull AD, Franklin P, Spector SA: Myelomeningocele in an infant with intrauterine exposure to efavirenz.

  • Efavirenz- a drug with complex DDI properties The antiviral drug, efavirenz, is a known perpetrator of DDIs via CYP2B6 and CYP3A4 induction.

  • However, you and your doctor may decide that the benefit of taking efavirenz is more important than the risks.

  • How should I take SUSTIVA.

If this happens, resistant virus can develop. If you find you are having problems taking your medications as directed, speak to your doctor and nurse about this. They can find ways to help you. When HIV becomes resistant to one drug in a class, it sometimes becomes resistant to other drugs in that class.

More about Efavirenz

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Where can I get more information?

  • Side effects: sleep disturbance including nightmaresmood changes including anxiety and depressionrash, liver toxicity, lipid changes, kidney problems.

  • HOW IS IT TAKEN.