Generic Name: Generic dulcolax
What is Generic Dulcolax?
However, there are not many studies describing the disposition of drug in children less than 5 years old. The FDA has requested this study to better understand how children ages 2 to 17 years with sickle anemia absorb and eliminate the drug this is called pharmacokinetics.
The investigators will measure how much Hydroxyurea HU gets into the bloodstream at different time points after taking this medication. Also, the following pharmacokinetic parameters will be derived for each participant using standard techniques: Apparent absorption rate constant, Apparent terminal elimination rate constant, Apparent steady state volume of distribution, Apparent plasma clearance. All females of child-bearing potential must be found to have a negative serum pregnancy test prior to initial dosing and be willing to practice appropriate contraceptive measures, including abstinence, from the time of the initial pregnancy testing through the remainder of the study 30 days after last administration of investigational agents.
The participant is able to ingest both capsule and liquid study articles and consume a minimum of 30 ml of water following ingestion of medication. EXCLUSION CRITERIA A participant will not be eligible for inclusion in this study if any of the following criteria apply: Chronic transfusion therapy, or transfused within 3 months of study participation.
Diagnoses other than sickle cell anemia or sickle beta-zero thalassemia i.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Hydroxyurea causes severe myelosuppression. Evaluate hematologic status prior to and during treatment with DROXIA. Provide supportive care and modify dose or discontinue DROXIA as needed. Recovery from myelosuppression is usually rapid when therapy is interrupted. Hydroxyurea is a human carcinogen.
In patients receiving long-term hydroxyurea for myeloproliferative disorders, secondary leukemia has been reported. Skin cancer has also been reported in patients receiving long-term hydroxyurea. Advise females of reproductive potential to use effective contraception during and after treatment with DROXIA for at least 6 months after therapy. Cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, have occurred in patients with myeloproliferative disorders during therapy with hydroxyurea.
These vasculitic toxicities were reported most often in patients with a history of, or currently receiving, interferon therapy.
How should I take Generic Dulcolax?
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What should I avoid while taking Generic Dulcolax?
Thank you so much for this review its very enlightening and a relieve. Thank you for this very insightful article. My question is can a SCD patient who has stage 3a kidney disease sickle cell nephropathy benefit from the intake of hydroxyurea. I am delighted tat so many people are finding the article helpful. If I can talk briefly on teh topics raised and this is just my view and perspective.
Generic Dulcolax side effects
You should not breast-feed while you are taking hydroxyurea. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Do not take this medicine in larger or smaller amounts or for longer than recommended. Drink 8 to 10 glasses of liquid per day while you are taking hydroxyurea. You may take the medicine with or without food. Hydroxyurea is either taken once per day or once every third day, depending on the condition being treated. On each of your dosing days, take the medicine at the same time of day.
Common Generic Dulcolax ide effects may include:
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal.
The inventors recognized that if these factors were avoided they could reduce toxicity and increase the tolerability of the combination, and so ensure the advantage of the combined used of didanosine and hydroxyurea for larger numbers of patients.
DROXIA may cause macrocytosis, which is self-limiting, and is often seen early in the course of treatment.
What happens if I miss a dose.
A seal coat or protective coat, which is applied on the core, will act to minimize the exposure risk of the patient to hydroxyurea powder and could improve stability of the formulation.
In yet another embodiment of the present invention, an enteric coating could be applied onto the tablet core to delay the release of the drug from the dosage form and synchronize the release of hydroxyurea with that of the other component, didanosine.
The composition comprises enteric polymers selected from cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polymethacrylates, polyvinylacetate phthalate, and acrylic polymers such as Eudragit and the like or a combination thereof.
The person skilled in the art will appreciate that the pharmaceutical composition of the invention may also contain one or more other pharmacologically active agents.
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