Generic Name: Dostinex
What is Dostinex?
Should pregnancy occur during treatment, cabergoline is to be discontinued. Regular gynaecological assessment, including cervical and endometrial cytology, is recommended for patients taking cabergoline for extensive periods.
Fibrosis and cardiac valvulopathy and possibly related clinical phenomena:Fibrotic and serosal inflammatory disorders such as pleuritis, pleural effusion, pleural fibrosis, pulmonary fibrosis, pericarditis, pericardial effusion, cardiac valvulopathy involving one or more valves aortic, mitral and tricuspid or retroperitoneal fibrosis have occurred after prolonged usage of ergot derivatives with agonist activity at the serotonin 5HT2B receptor, such as cabergoline.
In some cases, symptoms or manifestations of cardiac valvulopathy improved after discontinuation of cabergoline.
Chest x-ray examination is recommended in cases of unexplained ESR increases to abnormal values. Valvulopathy has been associated with cumulative doses, therefore, patients should be treated with the lowest effective dose.
At each visit, the risk benefit profile of cabergoline treatment for the patient should be reassessed to determine the suitability of continued treatment with cabergoline. Before initiating long-term treatment:All patients must undergo a cardiovascular evaluation, including echocardiogram to assess the potential presence of asymptomatic valvular disease.
In patients with valvular regurgitation, it is not known whether cabergoline treatment might worsen the underlying disease. If fibrotic valvular disease is detected, the patient should not be treated with cabergoline see section 4.
Dosage may be increased by 0. Before initiating treatment, cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.
Dosage increases should not occur more rapidly than every 4 weeks, so that the physician can assess the patient's response to each dosage level. If the patient does not respond adequately, and no additional benefit is observed with higher doses, the lowest dose that achieved maximal response should be used and other therapeutic approaches considered. Patients receiving long term treatment with DOSTINEX should undergo periodic assessment of their cardiac status and echocardiography should be considered.
After a normal serum prolactin level has been maintained for 6 months, DOSTINEX may be discontinued, with periodic monitoring of the serum prolactin level to determine whether or when treatment with DOSTINEX should be reinstituted. The durability of efficacy beyond 24 months of therapy with DOSTINEX has not been established.
DOSTINEX Tablets are white, scored, capsule-shaped tablets containing 0. Each tablet is scored on one side and has the letter P and the letter U on either side of the breakline.
The other side of the tablet is engraved with the number 700.
How should I take Dostinex?
DOSTINEX should be discontinued if an echocardiogram reveals new valvular regurgitation, valvular restriction or valve leaflet thickening.
DOSTINEX should be used with caution in patients exposed to other medications associated with valvulopathy. Postmarketing cases of pleural, pericardial, and retroperitoneal fibrosis have been reported following administration of DOSTINEX.
Some reports were in patients previously treated with other ergotinic dopamine agonists. DOSTINEX should not be used in patients with a history of cardiac or extracardiac fibrotic disorders.
Fibrotic disorders can have an insidious onset and patients should be monitored for manifestations of progressive fibrosis.
What should I avoid while taking Dostinex?
I actually had to reduce my dose to. I am just now going back to 2x per week this week. My doctor doesn't want me back in for labs until I have been on the medicine for 3 months. He told me it could work very quickly within weeks and he has had patients get pregant before they even get their first period. What kind if side effects were you having.
Dostinex side effects
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty. This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy.
Common Dostinex ide effects may include:
In the meantime, continue taking your medicine as prescribed.
A dose of 0.
After a normal serum prolactin level has been maintained for 6 months, DOSTINEX may be discontinued, with periodic monitoring of the serum prolactin level to determine whether or when treatment with DOSTINEX should be reinstituted.
Dostinex effectively lowers prolactin levels and shrinks tumor size in a high percentage of cases, making it a good first option in the treatment of both micro- and macroprolactinomas.
Rat studies show some transfer, but they are worthless in comparison to humans. This drug is extensively taken up first pass by the liver, and I would assume oral absorption is low. I don't personally think a waiting period is necessary but I have no data to support this.
Where can I get more information?
The prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.
Once prolactin levels are normal for six months, the patient can usually stop taking this medication.