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Closely monitor blood pressure, renal function, and electrolytes in patients on Diovan HCT and other agents that affect the RAS. Do not coadminister aliskiren with Diovan HCT in patients with diabetes. Hydrochlorothiazide: When administered concurrently, the following drugs may interact with thiazide diuretics:Antidiabetic Drugs oral agents and insulin - Dosage adjustment of the antidiabetic drug may be required.
Nonsteroidal Anti-inflammatory Drugs NSAIDs and COX-2 selective inhibitors - When Diovan HCT and nonsteroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Ion exchange resins: Staggering the dosage of hydrochlorothiazide and ion exchange resins e. Cyclosporine: Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.
That means that if you drink alcohol, this drug might take longer to leave your body. You also could have worse side effects. The use of drinks that contain alcohol can increase your risk of a sedative effect from this drug.
If you drink alcohol, talk to your doctor. You may have slowed reflexes, poor judgment, and sleepiness. This can be dangerous. These drugs include: potassium supplements salt substitutes potassium-sparing diuretics, such as: spironolactone triamterene This medicine may interact with other drugs that affect angiotensin.
These drugs include: angiotensin receptor blockers ARBssuch as: irbesartan candesartan losartan aliskiren angiotensin-converting enzyme ACE inhibitors, such as: lisinopril fosinopril enalapril Taking these drugs together may increase your chance for low blood pressure when you stand up from a sitting or lying position. These drugs include: cholestyramine colestipol Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Drug warnings People with dehydration or low salt levels This drug may lower your blood pressure too much if you have these conditions.
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Salmeterol: Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Saxagliptin: Angiotensin II receptor antagonists ARB may enhance the hypoglycemic effects of saxagliptin by improving insulin sensitivity. Serotonin norepinephrine reuptake inhibitors: Patients receiving a diuretic during treatment with venlafaxine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH.
Sertraline: Patients receiving a diuretic during treatment with sertraline may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH.
Discontinuation of sertraline should be considered in patients who develop symptomatic hyponatremia. Sevoflurane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Sibutramine: Sibutramine may raise blood pressure or heart rate.
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You may report side effects to the FDA at 1-800-FDA-1088. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Especially tell your doctor if you take:This is not a complete list of Diovan HCT drug interactions. Serious side effects have been reported with Diovan HCT including the following:Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Diovan HCT, salt substitutes containing potassium should be avoided. Before taking Diovan HCT, tell your doctor about all of your medical conditions.
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For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits.
The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality have also been seen regularly.
Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension e.
Some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients, and many antihypertensive drugs have additional approved indications and effects e. These considerations may guide selection of therapy.
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In some patients with compromised renal function who are being treated with NSAIDs, coadministration of angiotensin II receptor antagonists may result in further deterioration of renal function.
By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Use effective birth control while taking hydrochlorothiazide and valsartan.
The most common side effects with Diovan are dizziness and changes in kidney function tests.
Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs. Most commonly, these are "non-preferred" brand drugs.
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A search of prescribing information did not specifically list flushing as a side effect of Diovan.
This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise.