Generic Name: Generic dilantin
What is Generic Dilantin?
Phenytoin levels should be checked regularly when tinidazole therapy is undertaken. Additionally, phenytoin is an inducer of hepatic cytochrome P450 enzymes and may accelerate the elimination of tinidazole and decrease plasma concentrations of tinidazole.
Tipranavir: Hydantoin anticonvulsants increase the metabolism of the protease inhibitors and may lead to decreased efficacy of these medications. In addition, tipranavir may inhibit the CYP metabolism of hydantoins, resulting in increased hydantoin concentrations. Tizanidine: One case of increased phenytoin serum concentrations and associated drowsiness has been reported with the addition of tizanidine therapy.
The mechanism and significance of this potential interaction with phenytoin is unknown. Tofacitinib: Phenytoin is a CYP3A4 inducer, and tofacitinib exposure is decreased when coadministered with potent CYP3A4 inducers. Coadministration may result in reduced plasma concentration and subsequent reduced effectiveness of tolvaptan therapy and should be avoided. If coadministration is unavoidable, an increase in the tolvaptan dose may be necessary and patients should be monitored for decreased effectiveness of tolvaptan.
Other patients experienced a change of Topotecan: The interaction between topotecan and phenytoin was documented in a case report. Phenytoin coadministration increased topotecan lactone and total topotecan clearance from 43. Concomitant phenytoin increased the plasma AUC of total N-desmethyl topotecan from 7.
If co-therapy is continued, monitor blood glucose for changes in glycemic control. Capecitabine: Use caution if coadministration of capecitabine with phenytoin is necessary, monitoring phenytoin levels and watching for phenytoin-related adverse reactions e. Postmarketing reports indicate that some patients receiving both phenytoin and capecitabine have had toxicity associated with elevated phenytoin levels.
Carbamazepine: Carbamazepine induces hepatic microsomal enzymes, which, in turn, accelerates carbamazepine metabolism or the metabolism of other drugs. Interactions between carbamazepine and other anticonvulsants, such as the hydantoins, are complex. Despite the fact that one anticonvulsant may interact with another, combinations of anticonvulsants are frequently used in patients who are refractory to one agent alone and may change the profile of expected drug interactions.
Phenytoin or fosphenytoin and possibly ethotoin can potentially be affected by carbamazepine enzyme induction. Phenytoin plasma concentrations have also been reported to increase and decrease in the presence of carbamazepine. As carbamazepine is metabolized by CYP3A4, the potential exists for an interaction between carbamazepine and hydantoins, which induce CYP3A4 and therefore may decrease plasma concentrations of carbamazepine.
Careful monitoring of carbamazepine and hydantoin plasma concentrations, along with close clinical monitoring of response to therapy, is advised. The beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin. Monitor carefully for loss of therapeutic response. Carbinoxamine: Hydantoin anticonvulsants can theoretically add to the CNS depressant effects of other CNS depressants including the sedating H1 blockers.
Carbonic anhydrase inhibitors: Acetazolamide or methazolamide can induce osteomalacia in patients being concomitantly treated with hydantoin anticonvulsants. When combined, the effects on bone catabolism can be additive.
How should I take Generic Dilantin?
Valproic Acid, Divalproex Sodium: Phenytoin and valproic acid should be used together with caution. Valproic acid can displace phenytoin from protein-binding sites and inhibit its metabolism. Phenytoin can accelerate the metabolism of valproic acid. Phenytoin toxicity can occur if valproic acid is added to phenytoin. Loss of seizure control can occur as a result of lower valproic acid levels, although this would seem unlikely during the addition of a second anticonvulsant.
Because this interaction is complex, serum concentrations of both agents should be monitored closely, and the patient should be observed for loss of seizure control or the occurrence of phenytoin toxicity.
What should I avoid while taking Generic Dilantin?
Dosage reduction of phenytoin may be necessary if methylphenidate is coadministered. Similar interactions may occur with dexmethylphenidate. Inducers of CYP3A4, such as fosphenytoin or phenytoin, may increase hepatic elimination of quinidine and decrease its serum concentrations.
Quinidine concentrations should be monitored closely after the anticonvulsant is added to the treatment regimen. No special precautions appear necessary if these agents are begun several weeks before quinidine is added but quinidine doses may require adjustment if one of these agents is added or discontinued during quinidine therapy.
Generic Dilantin side effects
Dilantin can and may make you drowsy when you are taking it, whilst everyone will react differently when taking it as there is a chance of you becoming tired or getting a feeling of drowsiness you should be aware of this fact and not drive or operate machinery whilst taking it.
You can of course discuss this with your Doctor who will advise you of the best course of action if you are getting tired or sleepy when taking it. Is there a chance of me being allergic to Dilantin. There could be a very small chance that you will get an allergic reaction when you are taking Dilantin, and as such at the first signs of any type of allergic reaction you should seek urgent medical attention, and also let the medical staff know that you have taken this drug so as they will know what antidote or medical treatment to give, whilst rare you may, if you do take this drug suffer from an allergic reaction.
How to Purchase Dilantin You are rarely going to be able to purchase Dilantin and Phenytoin without a prescription from a Doctor and you should always avoid purchasing them without first having taken medical advice. Side Effects of Dilantin Some of the many side effects of taking both Dilantin and Phenytoin include abnormal eye movements, abnormal muscle movement, allergic or hypersensitivity reactions, autoimmune problems, blood and bone marrow problems, brain and central nervous system problems, breathing problems including respiratory arrest, cardiovascular collapse, coarsening of facial features, constipation, coordination problems and difficulty sleeping.
Common Generic Dilantin ide effects may include:
I have noticed side effects, mainly on sexual issues, along with fatigue, and brain fog, memory, etc.
Until further data are available, use caution when hydantoins such as phenytoin, fosphenytoin, or ethotoin are prescribed with diazoxide.
Leucovorin: Limited data suggest that leucovorin may interfere with the activity of anticonvulsants such as phenytoin.
Loperamide is metabolized by the hepatic enzyme CYP3A4, and is a substrate for the drug transporter P-glycoprotein P-gp.
Oxazepam: Hydantoin anticonvulsants can theoretically add to the CNS-depressant effects of other CNS depressants including oxazepam. In addition to additive pharmacodynamic effects, potential hepatic enzyme inducers such as hydantoins can theoretically increase the clearance of benzodiazepines metabolized by oxidative metabolism, leading to lower benzodiazepine concentrations. Oxcarbazepine: Phenytoin is a hepatic enzyme inducer and thus may accelerate the metabolism of several other anticonvulsants.
Phenytoin may decrease serum concentrations of oxcarbazepine. Also, oxcarbazepine can reduce phenytoin metabolism via inhibition of the CYP2C19 isozyme.
Where can I get more information?
Care should be taken when using immunoanalytical methods to measure serum phenytoin concentrations.
Drinking alcohol while taking DILANTIN may change your blood levels of DILANTIN which can cause serious problems.