Generic Name: Dilantin
What is Dilantin?
A rare complication is a confusional state that appears shortly after baclophen is started, but this resolves quickly when therapy is stopped. Baclophen should not be discontinued abruptly after prolonged use because hallucinations or seizures may occur.
If these withdrawal symptoms do occur, the previous dose of baclophen is usually re-instituted and then gradually reduced. Gabapentin is an anti-epileptic drug that is structurally related to the neurotransmitter GABA.
This drug is almost as effective as carbamazepine but involves fewer side effects. The starting dose is usually 300mg three times a day and this is increased to a maximal dose. The most common adverse reactions include somnolence sleepinessataxia decreased coordinationfatigue, and nystagmus rapid movements of the eye. Register Now Send the page "" to a friend, relative, colleague or yourself.
We do not record any personal information entered above. Phenytoin injection is contraindicated in patients with sinus bradycardia, sino-atrial block, second or third degree AV block, and Adams-Stokes syndrome because of the effects of the drug on ventricular automaticity. Intravenous phenytoin should not be used in patients with other cardiac conduction abnormalities e.
One case study documented an increase in total serum cholesterol concentrations when phenytoin was administered concurrently with another HMG Co-A reductase inhibitor, atorvastatin. Total serum cholesterol concentrations then decreased when phenytoin was discontinued.
Monitor for potential reduced cholesterol-lowering efficacy. Because phenytoin is a substrate of these enzymes, altered phenytoin exposure may occur. Lurasidone: Concurrent use of lurasidone with strong CYP3A4 inducers, such as phenytoin or fosphenytoin, is contraindicated.
Lurasidone is primarily metabolized by CYP3A4. Decreased blood concentrations of lurasidone are expected when the drug is co-administered with strong inducers of CYP3A4. Maprotiline: Maprotiline, when used concomitantly with anticonvulsants, can increase CNS depression and may also lower the seizure threshold.
Ethotoin, phenytoin or fosphenytoin may increase antidepressant metabolism. Monitor patients on anticonvulsants carefully when maprotiline is used concurrently.
Because of the lowering of seizure threshold, an alternative antidepressant may be a more optimal choice for patients taking drugs for epilepsy. Maraviroc: Coadministration of maraviroc, a CYP3A substrate, and phenytoin, a strong CYP3A inducer, without a concomitant strong CYP3A inhibitor may decrease maraviroc concentrations, therefore, the adult maraviroc dose should be increased to 600 mg PO twice daily when coadministered with phenytoin without a concomitant strong CYP3A inhibitor.
How should I take Dilantin?
These include an allergic skin rash that may form any time after the medication is started. Two to six percent of sufferers who take carbamazepine develop blood disorders including leukopenia or agranulocytosis drop in the number of white blood cellsor aplastic anemia when the bone marrow stops producing blood cells. A physician should be notified immediately and blood tests conducted if one experiences a fever, sore throat, stomatitis painful infection of the moutheasy bruising, or petechiae tiny red spots on the skin.
It has recently been found to be effective for some patients with trigeminal neuralgia. The dose usually begins at 300 mg twice a day and is gradually increased to achieve pain control.
What should I avoid while taking Dilantin?
A physician should be notified immediately and blood tests conducted if one experiences a fever, sore throat, stomatitis painful infection of the moutheasy bruising, or petechiae tiny red spots on the skin. It has recently been found to be effective for some patients with trigeminal neuralgia.
The dose usually begins at 300 mg twice a day and is gradually increased to achieve pain control. As with other anti-seizure medications, increasing and decreasing the dose should be gradual. Phenytoin relieves tic pain in over half of TN sufferers at doses of 300 to 500 mg, divided into three doses per day.
Phenytoin may also be administered intravenously to treat severe exacerbations of TN. The maximum dose depends upon the severity of the side effects that are experienced with the drug. These dose-dependant side effects include nystagmus rapid movements of the eyeataxia decreased coordinationdysarthria speech difficultyophthalmoplegia paralysis of eye movements as well as drowsiness and mental confusion.
Dilantin side effects
This seemed to resolve itself within the first month, but then zoomed up to 2-5 year period. I was on dilantin over 30 years started off taking 200 mgs a day to 600 mgs a day… Im still on dilantin slowly getting off it only because the liver problems it can cause…. Only problem i can say dilantin has caused me all these years is low folic acid over the years… Besides that it worked pretty good here the best out of any other med going….
Phenyabarbatal gave me hives and the ohers did nothing to help… If keppras side affects are going to be this way with feeling sore and getting headachs like this well than it will be back to the one and only grammpa of them all again for me…. They come out with new meds and jump saying this and that really after 30 plus years of KEPPRA what side affects will it cause people….
Im sure it will be more than having anemia and low folic acid…. Im thinking im going to stick to my dilantin and just go back to 600 mgs a day of that and say goodbye to keppra for good….
I had no problems taking Dilantin other than bone loss, and like you my doc felt Keppra was a better choice based on side effect profiles.
Common Dilantin ide effects may include:
Close monitoring of anticonvulsant serum concentrations is warranted due to the potential complex interactions that may take place with concurrent imatinib therapy.
I know ALL AEDs have their down-sides, but Lamictal and Klonopin have been very good to me.
Together, we can make a huge difference.
Magnesium sulfate is the preferred agent for use and is initiated in patients with preeclampsia who are showing signs of progression to severe preeclampsia or to eclampsia and in all women with diagnosed eclampsia.
After discontinuation of the CYP3A4 inducer, resume the previous vilazodone dose in 14 days. Vinblastine: Use caution when administering vinblastine concurrently with a CYP3A4 inducer such as phenytoin. Vinblastine is metabolized by CYP3A4 and phenytoin may decrease vinblastine plasma concentrations.
Agents that induce CYP 3A4 such as phenytoin may increase the metabolism of vincristine and decrease the efficacy of drug. Also, simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations that included non-liposomal vincristine sulfate have been reported to reduce blood levels of phenytoin and to increase seizure activity.
Where can I get more information?
Have you considered Gabapentin for nerve pain.
Although no clinical data are available to support a clinically significant interaction, citalopram may need to be administered in higher doses in patients chronically taking phenytoin.