Generic Name: Diflucan
What is Diflucan?
Tell them if you smoke, drink alcohol, or use illegal drugs because some of these items may interact with your medicine. How it should be used If you have any questions before you take this medicine, ask your doctor or the pharmacist.
Take the medicine with a full glass of water, with or without food, usually once a day. If you are taking the liquid form, shake the bottle well before each dose. Further Information see less Diflucan One general information What is Diflucan One used for. Diflucan One capsule 150mg is used to treat vaginal candidiasis vaginal thrush a yeast infection of the vagina with characteristic symptoms including vaginal itching and soreness, also white, odourless, discharge from the vagina.
Diflucan One is intended as a one-off oral treatment and you should have relief of symptoms after the first day, although it may take several days to be fully effective. How does Diflucan One work. Diflucan One capsules contain fluconazole, which a broad-spectrum antifungal drug belonging to the triazole group of antifungals.
Fluconazole in Diflucan One is a potent and specific inhibitor of fungal enzymes necessary for the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. Fluconazole in Diflucan One weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the infection, including, itching and inflammation.
What does Diflucan One contain.
Vinca alkaloids: Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids e. Vitamin A: Based on a case-report in one patient receiving combination therapy with all-trans-retinoid acid an acid form of vitamin A and fluconazole, CNS related undesirable effects have developed in the form of pseudotumour cerebri, which disappeared after discontinuation of fluconazole treatment.
Voriconazole: CYP2C9, CYP2C19 and CYP3A4 inhibitor : Coadministration of oral voriconazole 400 mg Q12h for 1 day, then 200 mg Q12h for 2. Monitoring for voriconazole associated adverse events is recommended if voriconazole is used sequentially after fluconazole.
Dose reduction of zidovudine may be considered. Azithromycin: An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin.
Oral contraceptives: Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazole. Ivacaftor: Co-administration with ivacaftor, a cystic fibrosis transmembrane conductance regulator CFTR potentiator, increased ivacaftor exposure by 3-fold and hydroxymethyl-ivacaftor M1 exposure by 1.
A reduction of the ivacaftor dose to 150 mg once daily is recommended for patients taking concomitant moderate CYP3A inhibitors, such as fluconazole and erythromycin. An observational study has suggested an increased risk of spontaneous abortion in women treated with fluconazole during the first trimester. There have been reports of multiple congenital abnormalities including brachycephalia, ears dysplasia, giant anterior fontanelle, femoral bowing and radio-humeral synostosis in infants whose mothers were treated for at least three or more months with high doses 400-800 mg daily of fluconazole for coccidioidomycosis.
The relationship between fluconazole use and these events is unclear.
How should I take Diflucan?
Capsules contain lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Concomitant use of the following other medicinal products is contraindicated: Cisapride: There have been reports of cardiac events including torsades de pointes in patients to whom fluconazole and cisapride were coadministered.
Concomitant treatment with fluconazole and cisapride is contraindicated see section 4. Terfenadine: Because of the occurrence of serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, interaction studies have been performed.
Another study at a 400 mg and 800 mg daily dose of fluconazole demonstrated that fluconazole taken in doses of 400 mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly. The combined use of fluconazole at doses of 400 mg or greater with terfenadine is contraindicated see section 4.
What should I avoid while taking Diflucan?
If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.
Diflucan side effects
Although not studied in vitro or in vivo, concomitant administration of fluconazole with quinidine may result in inhibition of quinidine metabolism. All subjects received the sulfonylurea alone as a single dose and again as a single dose following the administration of DIFLUCAN 100 mg daily for 7 days. In 13 normal male volunteers, there was significant increase in tolbutamide 500 mg single dose AUC and Cmax following the administration of fluconazole.
The AUC and Cmax of glipizide 2. The AUC and Cmax of glyburide 5 mg single dose were significantly increased following the administration of fluconazole in 20 normal male volunteers.
Common Diflucan ide effects may include:
Skin: rash, pruritus, exfoliative skin disorders including Stevens-Johnson syndrome Drug-drug.
Diflucan, the brand-name form of fluconazole, is a prescription medication used to treat fungal infections.
Drug Class Related Drugs Candida Urinary Tract Infection fluconazole, itraconazole, Sporanox, amphotericin b, flucytosine, Amphocin, More.
The order of study treatment was random.
Diflucan and PregnancyBack to TopTell your doctor if you are pregnant or plan to become pregnant. Diflucan and LactationBack to TopTell your doctor if you are breastfeeding or plan to breastfeed.
Diflucan OverdoseBack to TopIf you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. Contributors Anyssa Garza received her Doctor of Pharmacy degree from the University of Texas at Austin. Please Enable Frames, and Refresh This Page.
Where can I get more information?
Advanced services provide even greater screening benefits, including medication dose screening for pediatric ages twelve and under and geriatric sixty-five years and older patients.
Children's doses are based on the child's body weight and will be calculated by the prescriber.