Generic Name: Diclegis
What is Diclegis?
Pramlintide: Carbonic anhydrase inhibitors may alter blood sugar. Primidone: Acetazolamide can induce osteomalacia in patients treated chronically with barbiturates. Quinidine: Acetazolamide can decrease excretion of quinidine because carbonic anhydrase inhibitors increase the alkalinity of the urine, thereby increasing the amount of nonionized drug available for renal tubular reabsorption.
Quinine: Quinine and its metabolites are primarily excreted by the kidneys, and excretion is decreased when the urine is alkaline. Alkalinization of the urine by drugs such as acetazolamide and methazolamide can decrease the renal clearance of quinine. Increased plasma levels of quinine following reduced clearance can increase the risk of quinine-induced toxicity.
Repaglinide: Acetazolamide has rarely caused hyperglycemia and glycosuria in patients with diabetes mellitus, probably due to drug-induced hypokalemia.
Reserpine: The concomitant administration of reserpine with diuretics or other antihypertensive agents can result in additive hypotensive effects. This interaction may be desirable, but dosages should be adjusted accordingly.
Long-term administration of DIAMOX tablets is contra-indicated in patients with chronic non-congestive angle-closure glaucoma since it may permit organic closure of the angle to occur while the worsening glaucoma is masked by lowered intraocular pressure. DIAMOX tablets should not be used in patients hypersensitive to sulphonamides. A meta-analysis of randomised placebo controlled trials of anti-epileptic drugs has also shown a small increased risk of suicidal ideation and behaviour.
The mechanism of this risk is not known and the available data do not exclude the possibility of an increased risk for Acetazolamide. Therefore patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered. Patients and caregivers of patients should be advised to seek medical advice should signs of suicidal ideation or behaviour emerge. Increasing the dose often results in a decrease in diuresis.
Under certain circumstances, however, very large doses have been given in conjunction with other diuretics in order to secure diuresis in complete refractory failure. Fatalities have occurred, although rarely, due to severe reactions to sulphonamides. A precipitous drop in formed blood cell elements or the appearance of toxic skin manifestations should call for immediate cessation of DIAMOX tablets therapy. In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, DIAMOX tablets may aggravate acidosis and should be used with caution.
Concurrent administration of acetazolamide and aspirin may result in severe acidosis and increase central nervous system toxicity.
How should I take Diclegis?
What should I avoid while taking Diclegis?
Alprazolam: Concomitant administration of alprazolam with CNS-depressant drugs, including anticonvulsants, can potentiate the CNS effects of either agent. Amphetamine: Concurrent use of amphetamines and urinary alkalinizers, such as acetazolamide and methazolamide, should be avoided.
Urinary alkalinizers diminish the urinary excretion of amphetamines by increasing the proportion of non-ionized amphetamines, resulting in increased renal tubular reabsorption of these compounds. The half-life and therapeutic actions of amphetamines will be prolonged in the presence of these drugs. Amphotericin B lipid complex ABLC : Acetazolamide can potentiate hypokalemia and therefore can increase the risk of hypokalemia caused by amphotericin B.
Amphotericin B liposomal LAmB : Acetazolamide can potentiate hypokalemia and therefore can increase the risk of hypokalemia caused by amphotericin B.
Diclegis side effects
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Please enter a valid email. Highlights Side Effects Interactions How to Use Diamox Discontinued A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand. See which side effects you should report to your doctor right away.
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Common Diclegis ide effects may include:
If you are not sure please check with your regular doctor before ordering Diamox acetazolamide.
Leslie Lincoln, AR 11 Jun 21, 2009 How long did it take for you to notice a difference with diamox.
I now live in Mexico at an altitude just under that and was told last week by a pulmonary specialist that I would do better at a lower altitude.
Side effects Diamox acetazolamide may have side effects.
It should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Our bottom lineDiamox Acetazolamide is used to treat and prevent mountain sickness, as well as to lower the amount of fluid in the eye and legs. UpsidesConsidered as a first choice treatment for mountain sickness.
Where can I get more information?
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Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported see WARNINGS.