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DIAMOX SEQUELS acetazolamide xr provide prolonged action to inhibit aqueous humor secretion for 18 to 24 hours after each dose, whereas tablets act for only eight to 12 hours. The prolonged continuous effect of SEQUELS permits a reduction in dosage frequency.

Plasma concentrations of acetazolamide peak from three to six hours after administration of DIAMOX SEQUELS acetazolamide xrcompared to one to four hours with tablets. Caution is advised for early detection of such reactions and the drug should be discontinued and appropriate therapy instituted. In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, DIAMOX which may precipitate or aggravate acidosis should be used with caution.

If rapid ascent is undertaken and DIAMOX is used, it should be noted that such use does not obviate the need for prompt descent if severe forms of high altitude sickness occur, i.

Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported see WARNINGS. Both increases and decreases in blood glucose have been described in patients treated with acetazolamide. This should be taken into consideration in patients with impaired glucose tolerance or diabetes mellitus. Other, less serious side effects may be more likely to occur. Acetazolamide may elevate cyclosporine levels.

Laboratory Tests To monitor for hematologic reactions common to all sulfonamides, it is recommended that a baseline CBC and platelet count be obtained on patients prior to initiating DIAMOX therapy and at regular intervals during therapy.

Acetazolamide is contraindicated in patients with a history of acetazolamide hypersensitivity and should be avoided in patients with a history of carbonic anhydrase inhibitor hypersensitivity. While the risk of cross-sensitivity between acetazolamide and antibacterial sulfonamides appears low, acetazolamide should be discontinued in any person who exhibits reactions suggestive of sulfonamide hypersensitivity.

Rare fatalities have occurred due to severe hypersensitivity reactions to sulfonamides see Adverse Reactions. If signs of hypersensitivity or other serious reactions occur, discontinue use of acetazolamide.

Dosage reduction is warranted in patients with renal impairment. Acetazolamide may potentiate acidosis and cause neurologic side effects in dialysis patients. Plasma chloride levels and excretion of sodium and potassium are altered during treatment, and these conditions can be exacerbated by the renal and metabolic effects of the drug.

Long-term administration of acetazolamide is contraindicated in patients with closed-angle glaucoma as acetazolamide may allow closure of the angle to occur while lowered intraocular pressure masks the worsening glaucoma. Patients with pulmonary disease, including those with pulmonary infection, obstruction, emphysema, or respiratory acidosis should be monitored closely during treatment with acetazolamide because of the potential for respiratory acidosis.

Acetazolamide, as with other sulfonamide derivatives, can induce bone marrow suppression, agranulocytosis, aplastic anemia, and other blood dyscrasias so precaution is advised for early detection of such reactions.

If they occur, the drug should be discontinued and appropriate therapy instituted. Like other sulfonamide derivatives, photosensitivity may occur with carbonic anhydrase inhibitors including acetazolamide. Some patients may be more sensitive to sunlight UV exposure while receiving acetazolamide.

There are not adequate and well-controlled studies in pregnant women. Acetazolamide should only be used if the benefit justifies the potential risk to the fetus.

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Commonly Used Brand Name s Diamox Sequels, Glauctabs, Keveyis, NeptazaneCarbonic anhydrase inhibitors are used to treat glaucoma. Acetazolamide is also used as an anticonvulsant to control certain seizures in the treatment of epilepsy. It is also sometimes used to prevent or lessen some effects in mountain climbers who climb to high altitudes, and to treat other conditions as determined by your doctor.

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They feel it is better to acclimatize naturally and ascend slowly with breaks - giving the body sufficient time to get used to the higher altitude. On the other hand the non purists think it is better to be safe than suffer from high altitude sickness. They feel being on a course of Acetazolamide Diamox would give them maximum chance of success on a high altitude trek. So they start on a course of Diamox even before they begin their trek.

Now what is the right thing to do.

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Hi, My doc gives me Diamox for weather headaches. It was originally used by mountain climbers to deal with air pressure changes. Diamox is one of over 100 medications that can and are used for migraine prevention.

Diamox, generic name acetazolamide, is a carbonic anhydrase inhibitor. Some people have very good luck with it.

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  • How it works in AMS is unknown, this drug removes symptoms of AMS fast, but has the potential to mask symptoms of AMS.

  • Ibuprofen Decreases Brain Swelling: As we ascend to higher altitudes, our bodies adjust to decreased oxygen in the air and reduction in air pressure, which leads to a swelling of the brain in some climbers.