Generic Name: Generic depakote
What is Generic Depakote?
Dermatologic: Hair texture changes, hair color changes, photosensitivity, erythema multiforme, toxic epidermal necrolysis, nail and nail bed disorders, and Stevens-Johnson syndrome. Psychiatric: Emotional upset, psychosis, aggression, psychomotor hyperactivity, hostility, disturbance in attention, learning disorder, and behavioral deterioration. There have been reports of acute or subacute encephalopathy in the absence of elevated ammonia levels, elevated valproate levels, or neuroimaging changes.
The encephalopathy reversed partially or fully after valproate discontinuation. Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases such as ritonavirmay increase the clearance of valproate.
For example, phenytoin, carbamazepine, and phenobarbital or primidone can double the clearance of valproate. Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs. In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e. Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn.
The following list provides information about the potential for an influence of several commonly prescribed medications on valproate pharmacokinetics. The list is not exhaustive nor could it be, since new interactions are continuously being reported.
Experience employing dosing regimens from once-a-day to four-times-a-day, as well as studies in primate epilepsy models involving constant rate infusion, indicate that total daily systemic bioavailability extent of absorption is the primary determinant of seizure control and that differences in the ratios of plasma peak to trough concentrations between valproate formulations are inconsequential from a practical clinical standpoint.
Whether or not rate of absorption influences the efficacy of valproate as an antimanic or antimigraine agent is unknown. Nonetheless, any changes in dosage administration, or the addition or discontinuance of concomitant drugs should ordinarily be accompanied by close monitoring of clinical status and valproate plasma concentrations. Protein binding of valproate is reduced in the elderly, in patients with chronic hepatic diseases, in patients with renal impairment, and in the presence of other drugs e.
Conversely, valproate may displace certain protein-bound drugs e. Valproate is metabolized almost entirely by the liver. The kinetics of unbound drug are linear. Mean plasma clearance and volume of distribution for total valproate are 0. Mean plasma clearance and volume of distribution for free valproate are 4. Mean terminal half-life for valproate monotherapy ranged from 9 to 16 hours following oral dosing regimens of 250 to 1,000 mg.
The estimates cited apply primarily to patients who are not taking drugs that affect hepatic metabolizing enzyme systems. For example, patients taking enzyme-inducing antiepileptic drugs carbamazepine, phenytoin, and phenobarbital will clear valproate more rapidly. Because of these changes in valproate clearance, monitoring of antiepileptic concentrations should be intensified whenever concomitant antiepileptics are introduced or withdrawn.
Children within the first two months of life have a markedly decreased ability to eliminate valproate compared to older children and adults.
How should I take Generic Depakote?
In clinical studies, patients have been found to respond to the effects of Depakote after just ten days of treatment. In these studies Depakote was found to be safe in treating a sample of 360 patients for more than three months. However, since Depakote is new on the market for the treatment of mania in bipolar disorder, studies are limited and safety and effectiveness in longer trials have not yet been established.
As with any medication, physicians who prescribe Depakote for extended periods of time should continually reevaluate the patient and the drug's overall short- and long-term effects.
Depakote is a major advance in the treatment of manic episodes associated with bipolar disorder. It is an effective and well-tolerated treatment that offers new hope for patients. There are a number of anti-depressant medications available for treating the depressive episodes of manic depression, but there are only two approved by the FDA for treating mania: lithium and Depakote.
What should I avoid while taking Generic Depakote?
I was then switched to kepra when i was 18 after i refused to take any medicine that interfered with my life so much. At first the medicine did its job, not perfect but at least no serious side affect that i could see. After 2 months kepra reared its ugly head. The side affect i experienced was emotional, it sucked worse than the drowsiness.
I felt like i was outside of my body because that person wasnt me. I remember going into fits and laughing at myself because i thought "who could be this bitchy" but having no control over stopping it. To me it wasnt my fault, it was everyone elses.
Generic Depakote side effects
Depakote Uses Depakote is approved by the FDA to treat epilepsy, bipolar disorder and migraine headaches. EpilepsyDepakote is used to treat epilepsy, a brain disorder that causes recurring, unprovoked seizures. Depakote Indications and Precautions For seizures, the recommended initial dose depends on the weight of the patient.
Depakote manufacturer AbbVie warns that you should not take Depakote or Depakene if you: Have liver problems Have or think you have a genetic liver problem caused by a mitochondrial disorder e.
Rare side effects of Depakote and Depakene include: Liver problems Low platelets Pancreatitis inflammation of the pancreas. Symptoms of pancreatitis include severe stomach pain, nausea, vomiting, and not feeling hungry. Symptoms may include confusion, disorientation, or difficulty thinking.
Common Generic Depakote ide effects may include:
Results In several clinical studies, Divalproex sodium Depakote has been shown to improve social skills, aggression, unstable behavior, and receptive language.
Close Sign In to myNAMI signin form Forgot Sign In Create an Account Logging in.
Depakote for Epilepsy As an anticonvulsant, Depakote is often used to treat epilepsy and was first approved for this purpose in 1983.
Depakote is a popular medication, and has helped millions of people with severe medical conditions.
I have been on every drug under the sun I was a guinea pig all through my college years, because I was pretty resistant to control but the one drug I have been on all those years has been Dilantin. It and for the last 15 years or soDepakote have largely controlled my seizures - I went for an unprecendented 9 years without a grand mal although the absence spells have nevernot been a regular feature of my life. I refused to go off of it years ago because it controlled my seizures - now I wish I had.
Where can I get more information?
Depakote Question: What is the complete list of side effects for Depakote.
So if nursing homes used it in place of other options, they could avoid the administrative costs and burdens of complying with that law.