Generic Name: Depakote

What is Depakote?

According to the literature available, sexual dysfunction and changes in libido performance were not reported side effects associated with treatment with Depakote. If you have been experiencing a change in libido, you may want to contact your health care provider to determine the cause and best treatment option available. Beth Isaac, PharmDQ: Does Depakote taken over years ruin your liver. I take 1,000 mg daily. Common side effects of Depakote may include tremor, somnolence, and diplopia or double vision.

A search of prescribing information did report that hepatic failure resulting in fatalities has occurred in people receiving Depakote and other similar drugs. Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. In patients with epilepsy, a loss of seizure control may also occur. Patients should be monitored closely for appearance of these symptoms.

National Library of Medicine The navigation menu has been collapsed. How should this medicine be used. Other uses for this medicine What special precautions should I follow. What special dietary instructions should I follow. What should I do if I forget a dose.

What side effects can this medication cause. What should I know about storage and disposal of this medication. Brand names Other names IMPORTANT WARNING: Valproic acid may cause serious or life threatening damage to the liver and is most likely to occur within the first 6 months of therapy.

Why is this medication prescribed. Do not mix the syrup into any carbonated drink. Your doctor may start you on a low dose of valproic acid and gradually increase your dose. What special precautions should I follow. Before taking valproic acid,tell your doctor and pharmacist if you are allergic to valproic acid, any other medications, or any of the ingredients in the type of valproic acid that has been prescribed for you.

How should I take Depakote?

Last year, British drugmaker GlaxoSmithKline announced that it expects to reach a bigger settlement this year related to its development and promotion of the diabetes drug Avandia, among others.

As part of the settlement, Abbott admitted that beginning in 1998 it trained a special sales force to promote Depakote to nursing-home employees as a way to control the agitation and aggression that can occur in elderly patients suffering from dementia.

Yet the sales team continued to push the drug to nursing homes through 2006. In its marketing, Abbott highlighted the fact that Depakote was not covered by a 1987 law designed to prevent the use of unnecessary medications by nursing homes. So if nursing homes used it in place of other options, they could avoid the administrative costs and burdens of complying with that law.

The attorney for Meredith McCoyd, one of four former Abbott sales representatives whose whistleblower lawsuits prompted the investigation, said the company offered nursing homes a second rationale. Abbott also enlisted the help of pharmacies that serve long-term-care facilities, offering rebates based on how much they increased the use of Depakote in the nursing homes they served, according to the settlement.

What should I avoid while taking Depakote?

It is used to prevent seizures in people with epilepsy, but can also be used for other conditions or symptoms, including bipolar disorder and migraines. Depakote is effective for many people, but can also cause side effects that range from mild to very serious. It is these serious side effects that have led to lawsuits against the makers of Depakote.

Abbott Laboratories has been making and selling Depakote in several different forms, from injections to liquids and tablets, but now is facing a number of lawsuits.

The medication has been tied to serious birth defects, liver failure, and pancreatitis.

Depakote side effects

These defects occur in fewer than two out of every 100 babies born to mothers who use Depakote or Depakene during pregnancy. The FDA found that taking Depakote during pregnancy increases the risk of developing birth defects such as neural tube defects from 1 in 1,500 babies to 1 in 20.

A study published in the New England Journal of Medicine indicated that children whose mothers took Depakote during the first trimester of pregnancy are more than 12 times more likely to be born with spina bifida, a neural tube defect that results from the spinal column not completely closing during fetal development, leaving the spinal cord exposed.

The tests were given at multiple ages and measured intelligence, abstract reasoning and problem-solving. An article published in the Journal of the American Medical Association linked prenatal valproate exposure to autism spectrum disorders and childhood autism. A 2008 FDA analysis of 199 trials of people taking antiepileptic drugs, including Depakote, found that those taking the drugs have twice the risk of suicidal thinking than patients taking a placebo.

Common Depakote ide effects may include:

  • Tell your doctor if you are not able to eat or drink as you normally do.

  • That's when I realized that the Keppra might be making me think this way.

  • Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.

  • A good correlation has not been established between daily dose, serum concentrations, and therapeutic effect.

Then Keppra as the last option. I also suffered with hair loss and weight gain. Unfortunately, due to these side effectd and ignorance we decided to stop medications and for years i just dealt with the absence seizures. The side are effects are definately not as severe for me although there are some. I was then switched to kepra when i was 18 after i refused to take any medicine that interfered with my life so much.

Where can I get more information?

  • It is known to cause serious abnormalities in the baby if taken during pregnancy.

  • Where can I get more information.