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While generally safe and effective when prescribed by a veterinarian, cyclophosphamide can cause side effects in some dogs and cats. Cyclophosphamide should not be used in animals with known hypersensitivity or allergy to the drug. Because of its effects on rapidly growing cells, cyclophosphamide should be used with caution in animals with bone-marrow problems. Some of the adverse effects of cyclophosphamide treatment include vomiting, diarrhea, loss of appetite, bladder irritation sterile cystitis and bone-marrow suppression.

With bone-marrow suppression, dangerously low red blood cell counts can lead to the need for blood transfusions. Cyclophosphamide is available in 25 mg and 50 mg tablets. It is also available in various concentrations for injection. Medication should never be administered without first consulting your veterinarian.

For cancer treatment, cyclophosphamide is dosed at 0.

I was sweating that much after the AC that I sweated the marks off and got told off. Later on, my skin started to burn with the treatment. I got side effects with that. I suffer allergies and Taxol makes them worse, apparently. I am now out the other side and am happy to be alive. Sending all my best and a virtual hug.

I just wanted to that that this was exactly my experience, and your post reflects my headspace and mindset via this whole thing. Felt like a breath of fresh air. You are commenting using your WordPress. I started this Blog on the day of my diagnosis with Stage 3 Triple Positive Cancer. I've documented every step along the Breast Cancer path - Mastectomy, Chemotherapy, Radiation, Herceptin, Hormone Therapy, Aromatase Inhibitors, and transition to Cancer Survivor.

May Reply Denise McCroskey October 5, 2013 at 9:19 am May, thanks for sharing your experiences so they can help others.

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This drug should be used with caution in patients with severe renal impairment. Cyclophosphamide and its metabolites are removed through dialysis hence if given to patients on dialysis, a consistent interval between cyclophosphamide administration and dialysis should be maintained. Meirow D, Epstein M, Lewis H, Negent D, and Gosden RG 2001 Administration of Cyclophosphamide at different stages of follicular maturation in mice: effects on reproductive performance and feta malformations.

Comparative rivew of 5-HT3 receptor antagonists in the treatment of acute chemotherapy induced nausea and vomiting. Huong DL, Amoura Z, Duhaut P. Primary Menu Skip to contentAccueil Qui sommes-nous. Check your inbox for an e-mail with a link to download the recipesAdriamycin doxorubicin and Cytoxan cyclophosphamide make up the chemotherapy regimen known as AC.

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Skin and its structures Alopecia occurs in patients treated with cyclophosphamide. Natalizumab Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. Thiazide diuretics Zidovudine Increased cardiotoxicity may result from a combined effect of cyclophosphamide and, for example: Anthracyclines Cytarabine Pentostatin Radiation therapy of the cardiac region Trastuzumab Increased pulmonary toxicity may result from a combined effect of cyclophosphamide and, for example: Amiodarone G-CSF, GM-CSF granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor : Reports suggest an increased risk of pulmonary toxicity in patients treated with cytotoxic chemotherapy that includes cyclophosphamide and G-CSF or GMCSF.

Increased nephrotoxicity may result from a combined effect of cyclophosphamide and, for example: Amphotericin B Indomethacin: Acute water intoxication has been reported with concomitant use of indomethacin Increase in other toxicities: Azathioprine: Increased risk of hepatotoxicity liver necrosis Busul Protease inhibitors: Increased incidence of mucositis Increased risk of hemorrhagic cystitis may result from a combined effect of cyclophosphamide and past or concomitant radiation treatment.

Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Urinary Tract and Renal Toxicity Hemorrhagic cystitis, pyelitis, ureteritis, and hematuria have been reported with cyclophosphamide.

Cardiotoxicity Myocarditis, myopericarditis, pericardial effusion including cardiac tamponade, and congestive heart failure, which may be fatal, have been reported with cyclophosphamide therapy Supraventricular arrhythmias including atrial fibrillation and flutter and ventricular arrhythmias including severe QT prolongation associated with ventricular tachyarrhythmia have been reported after treatment with regimens that included cyclophosphamide.

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Rarely, cyclophosphamide side effects in children may include: Bruising or bleeding Painful urination Lower back or abdominal pain Persistent cough Rash Hives Itching Difficulty breathing Redness Swollen lips Fever Chills Sore throat Blood in urine Dizziness Darkening of the skin or fingernails If your child has trouble with any of these side effects, inform your transplant doctor. Cyclophosphamide Drug Interactions Tell your doctor or pharmacist about any prescription or over-the-counter medication your child is taking, so you can be warned of interactions and prevent them.

Taxane subsets ABI-007 subset and Taxol subset treatment arms summarize participants with treatment-emergent toxicities defined as any AEs that begin or worsen in severity grade after the start of taxane treatment cycle 5, week 9 through 30 days after the last dose of taxane week 20 and were ongoing 3 months after chemotherapy month 7.

Taxane subsets ABI-007 subset and Taxol subset treatment arms summarize participants with treatment-emergent toxicities defined as any AEs that begin or worsen in severity grade after the start of taxane treatment cycle 5, week 9 through 30 days after the last dose of taxane week 20 and were ongoing 6 months after chemotherapy month 10.

Myelosuppression represented by neutropenia low absolute neutrophil counts ANC with severity grades according to Common Terminology Criteria for Adverse Events v3. Values are reported across all severity grades without assessment of relationship to taxane treatment, and also by relation to taxane treatment as reported by investigators.

Summary of the most severe grades using the National Cancer Institute's Common Terminology Criteria for Adverse Events v3.

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  • This disease can occur in the subjects even if they are not receiving rituximab treatment, but have also been reported in subjects who are receiving rituximab.

  • I always felt I received the special gift of breast cancer because I am such a blabber-mouth and hope I can remove some of the pain of this disease by, at least, listening.

  • The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Basically they are saying since I'm on CellCept currently that they are considering keeping me on Cellcept instead of Cytoxin since Cellcept is less harsh when it comes to side effects, and then add this new medicine which doesn't have much side effects.

This way this will protect my sperm and all that fertility effects that are know with Cytoxin. Will keep you posted.

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  • The authors found that the mean absolute difference in adjusted 12-month forced vital-capacity percent predicted was 2.

  • What happens if I overdose Cytoxan.