Generic Cymbalta

Generic Name: Generic cymbalta

What is Generic Cymbalta?

CYMBALTA is indicated for the management of chronic musculoskeletal pain. This has been established in studies in patients with chronic low back pain and chronic pain due to osteoarthritis.

The efficacy of CYMBALTA in chronic low back pain CLBP was assessed in two double-blind, placebo-controlled, randomized clinical trials of 13-weeks duration Study CLBP-1 and Study CLBP-2and one of 12-weeks duration CLBP-3.

CLBP-1 and CLBP-3 demonstrated efficacy of CYMBALTA in the treatment of chronic low back pain. Patients in all studies had no signs of radiculopathy or spinal stenosis. Patients had a mean baseline pain rating of 6 on a numerical rating scale ranging from 0 no pain to 10 worst possible pain. After 13 weeks of treatment, patients taking CYMBALTA 60-120 mg daily had a significantly greater pain reduction compared to placebo.

Subgroup analyses did not indicate that there were differences in treatment outcomes as a function of NSAIDs use.

After 13 weeks of treatment, none of the three CYMBALTA doses showed a statistically significant difference in pain reduction compared to placebo. After 12 weeks of treatment, patients taking CYMBALTA 60 mg daily had significantly greater pain reduction compared to placebo.

Based upon in vitro studies, the circulating metabolites of duloxetine are considered pharmacologically inactive. The pharmacokinetics of duloxetine in patients who are poor metabolisers with respect to CYP2D6 has not been specifically investigated.

Limited data suggest that the plasma levels of duloxetine are higher in these patients. Elimination: The elimination half-life of duloxetine ranges from 8 to 17 hours mean of 12 hours. Based upon the overlap in the range of clearance, gender-based pharmacokinetic differences do not justify the recommendation for using a lower dose for female patients. Hepatic impairment: Moderate liver disease Child-Pugh Class B affected the pharmacokinetics of duloxetine.

The pharmacokinetics of duloxetine and its metabolites have not been studied in patients with mild or severe hepatic insufficiency. Breast-feeding mothers: The disposition of duloxetine was studied in 6 lactating women who were at least 12-weeks postpartum.

Duloxetine is detected in breast milk, and steady-state concentrations in breast milk are about one-fourth those in plasma. Lactation did not influence duloxetine pharmacokinetics.

How should I take Generic Cymbalta?

If most of the day has passed, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater e.

Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects.

What should I avoid while taking Generic Cymbalta?

The physician should consider contacting a poison control center 1-800-222-1222 or www. Monoamine Oxidase Inhibitors MAOIs - The use of MAOIs intended to treat psychiatric disorders with CYMBALTA or within 5 days of stopping treatment with CYMBALTA is contraindicated because of an increased risk of serotonin syndrome.

Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS. Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.

Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors in vitro.

Generic Cymbalta side effects

Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. This leaflet answers some common questions about CYMBALTA. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

The information in this leaflet was last updated on the date shown on the final page. More recent information on this medicine may be available.

Common Generic Cymbalta ide effects may include:

  • Do not stop taking this medicine abruptly without consulting with your doctor.

  • In this way, duloxetine helps relieve depression.

  • Cymbalta 60 mg Cymbalta 60 mg is available in packs of 28, 56, 84 and 98 hard gastro-resistant capsules and in multipacks containing 100 5 packs of 20 and 500 25 packs of 20 hard gastro-resistant capsules.

  • Based upon the overlap in the range of clearance, gender-based pharmacokinetic differences do not justify the recommendation for using a lower dose for female patients.

IS it regulating the release. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive. User Done Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected.

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  • However, safety and efficacy have not been established in children younger than 7 years of age.

  • I was originally looking up the "electrical shock sensation" today and ended up on "Cymbalta withdrawal".