Generic Name: Cymbalta
What is Cymbalta?
Caution is advised in using CYMBALTA in patients with conditions that may slow gastric emptying e. Drugs that raise the gastrointestinal pH may lead to an earlier release of duloxetine. However, co-administration of CYMBALTA with aluminum-and magnesium-containing antacids 51 mEq or CYMBALTA with famotidine, had no significant effect on the rate or extent of duloxetine absorption after administration of a 40 mg oral dose.
In vitro drug interaction studies demonstrate that duloxetine does not induce CYP1A2 activity. Therefore, an increase in the metabolism of CYP1A2 substrates e. Duloxetine is a moderate inhibitor of CYP2D6. Results of in vitro studies demonstrate that duloxetine does not inhibit activity.
Results of in vitro studies demonstrate that duloxetine does not inhibit or induce CYP3A activity. When CYMBALTA and ethanol were administered several hours apart so that peak concentrations of each would coincide, CYMBALTA did not increase the impairment of mental and motor skills caused by alcohol. In the CYMBALTA clinical trials database, three CYMBALTA-treated patients had liver injury as manifested by ALT and total bilirubin elevations, with evidence of obstruction.
It may take between two to four weeks for the benefits of this medicine to appear, so it is very important that you keep taking it, even if it doesn't seem to make much difference at first. If you feel your depression or anxiety has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor. This medicine is also used to treat nerve pain in the feet, legs or hands that is due to nerve damage caused by poorly controlled diabetes.
Duloxetine is thought to enhance the nerve signals within the central nervous sytem that naturally inhibit pain. This medicine should not be used if you are allergic to one or any of its ingredients.
Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine.
Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. See also the warning section above. The side effects listed may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
How should I take Cymbalta?
Symptoms may include: skin blisters peeling rash sores in your mouth hives manic episodes in people with depression or bipolar disorder. Symptoms may include: greatly increased energy severe trouble sleeping racing thoughts reckless behavior unusually grand ideas excessive happiness or irritability talking more or faster than usual vision problems. Symptoms may include: eye pain changes in vision swelling or redness in or around your eye seizures or convulsions low salt sodium levels in your blood.
Symptoms may include: headache weakness or feeling unsteady confusion, problems concentrating, or thinking or memory problems problems with urination.
Symptoms may include: decrease in your urine flow trouble passing urine Disclaimer: Our goal is to provide you with the most relevant and current information. Examples of drugs that can cause interactions with promethazine are listed below.
Drugs that affect serotonin Duloxetine affects a chemical in your brain called serotonin. Nonsteroidal anti-inflammatory drugs Taking both duloxetine and NSAIDs may increase your risk of abnormal bleeding.
What should I avoid while taking Cymbalta?
Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors in vitro. Duloxetine does not inhibit monoamine oxidase MAO. Duloxetine has an elimination half-life of about 12 hours range 8 to 17 hours and its pharmacokinetics are dose proportional over the therapeutic range. There is a median 2 hour lag until absorption begins Tlagwith maximal plasma concentrations Cmax of duloxetine occurring 6 hours post dose.
There is a 3 hour delay in absorption and a one-third increase in apparent clearance of duloxetine after an evening dose as compared to a morning dose.
Cymbalta side effects
The physician should consider contacting a poison control center 1-800-222-1222 or www. Monoamine Oxidase Inhibitors MAOIs - The use of MAOIs intended to treat psychiatric disorders with CYMBALTA or within 5 days of stopping treatment with CYMBALTA is contraindicated because of an increased risk of serotonin syndrome. Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.
Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors in vitro.
Duloxetine does not inhibit monoamine oxidase MAO. Duloxetine has an elimination half-life of about 12 hours range 8 to 17 hours and its pharmacokinetics are dose proportional over the therapeutic range.
Common Cymbalta ide effects may include:
Chronic Low Back Pain The most commonly observed adverse reactions in CYMBALTA-treated patients as defined above were nausea, dry mouth, insomnia, somnolence, constipation, dizziness, and fatigue.
Nausea The most common negative side effect of Cymbalta is nausea.
Taking it at the same time each day will have the best effect.
A Timeline of the Cymbalta Lawsuits - This post summarizes the Cymbalta lawsuits that have been to court so far and their outcomes.
This is long, but hoping it will help someone who really wants to get past this without more harm to your health than necessary. Hugz The Bead Method of Tapering off Cymbalta - Digital Scale Info.
See if you can find a knowledgeable doctor preferably a functional medical doctor to help.
Where can I get more information?
Generalized Anxiety Disorder GAD occurs when a person experiences excessive anxiety or worry for at least six months.
Taking Cymbalta while taking blood thinners like Coumadin, ibuprofen, or aspirin can increase the risk of abnormal bleeding.