Cyclogyl

Generic Name: Cyclogyl

What is Cyclogyl?

Although specific interactions have not been studied, indinavir may interfere with the metabolism of CYP3A4 substrates, such as levobupivacaine, and caution is warranted with coadministration. Levomethadyl: Agents that inhibit CYP3A4, including indinavir, may decrease the metabolism of levomethadyl, increase levomethadyl levels, and may precipitate severe arrhythmias including torsade de pointes. Indinavir is considered a strong inhibitor of CYP3A4. Levomilnacipran is partially metabolized by CYP3A4, and decreased metabolism of the drug can lead to an increased risk of adverse effects such as urinary retention.

Levothyroxine: Closely monitor the thyroid status of any patient taking thyroid hormones concurrently with indinavir. Lidocaine: Anti-retroviral protease inhibitors can inhibit hepatic cytochrome P450 3A4, an isoenzyme that is partially responsible for the metabolism of lidocaine. Linagliptin: New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have been reported with use of anti-retroviral protease inhibitors.

Liothyronine: Closely monitor the thyroid status of any patient taking thyroid hormones concurrently with indinavir. Liotrix: Closely monitor the thyroid status of any patient taking thyroid hormones concurrently with indinavir. Lomitapide: Concomitant use of indinavir and lomitapide is contraindicated. If treatment with indinavir is unavoidable, lomitapide should be stopped during the course of treatment.

The exposure to lomitapide was increased 27-fold in the presence of ketoconazole, a strong CYP3A4 inhibitor.

Drug interaction studies were performed with CRIXIVAN and other drugs likely to be coadministered and some drugs commonly used as probes for pharmacokinetic interactions. The effects of coadministration of CRIXIVAN on the AUC, Cmax and Cmin are summarized in Table 2 effect of other drugs on indinavir and Table 3 effect of indinavir on other drugs.

Quinidine 200 single dose 400 single dose 10 0. Sildenafil 25 single dose 800 three times daily 6 See text below for discussion of interaction. Delavirdine inhibits the metabolism of indinavir such that coadministration of 400-mg or 600-mg indinavir three times daily with 400-mg delavirdine three times daily alters indinavir AUC, Cmax and Cmin see Table 2. Administration of indinavir 800 mg every 8 hours with methadone 20 mg to 60 mg daily for one week in subjects on methadone maintenance resulted in no change in methadone AUC.

Based on a comparison to historical data, there was little or no change in indinavir AUC. Compared to historical data in patients who received indinavir 800 mg every 8 hours alone, twice-daily coadministration to volunteers of indinavir 800 mg and ritonavir with food for two weeks resulted in a 2. In the same study, twice-daily coadministration of indinavir 800 mg and ritonavir 100 or 200 mg resulted in ritonavir AUC24h increases versus the same doses of ritonavir alone see Table 3.

In all clinical studies, with the exception of ACTG 320, the AMPLICOR HIV MONITOR assay was used to determine the level of circulating HIV RNA in serum. This is an experimental use of the assay.

How should I take Cyclogyl?

Dofetilide: Coadministration of CYP3A4 inhibitors, such as indinavir, with dofetilide may decrease the metabolism of dofetilide, thereby increasing the potential for QT prolongation. Dofetilide is a Class III antiarrhythmic agent that has a well-established risk of QT prolongation and torsade de pointes TdP.

Plasma dofetilide concentrations are correlated with the risk of drug-induced proarrhythmias. Donepezil: Indinavir inhibits cytochrome P450 3A4 and may interfere with the metabolism of CYP3A4 substrates, such as donepezil.

Doxercalciferol: Protease inhibitors may decrease efficacy of doxercalciferol.

What should I avoid while taking Cyclogyl?

Taking these drugs together may increase daclatasvir serum concentrations, and potentially increase the risk for adverse effects. In addition, the therapeutic effects of indinavir, a P-glycoprotein P-gp substrate, may be increased by daclatasvir, a P-gp inhibitor.

Dapagliflozin: New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have been reported with use of anti-retroviral protease inhibitors.

Darifenacin: Antiretroviral protease inhibitors may decrease the metabolism of darifenacin leading to a possible increase in adverse anticholinergic effects. Darunavir: Concurrent administration of darunavir and indinavir results in increased darunavir and indinavir concentrations.

Cyclogyl side effects

Continue taking CRIXIVAN unless your doctor tells you to stop. Take the exact amount of CRIXIVAN that your doctor tells you to take, right from the very start.

To help make sure you will benefit from CRIXIVAN, you must not skip doses or take "drug holidays". If you don't take CRIXIVAN as prescribed, the activity of CRIXIVAN may be reduced due to resistance.

Take CRIXIVAN capsules every 8 hours around the clock, every day. It may be easier to remember to take CRIXIVAN if you take it at the same time every day. If you have questions about when to take CRIXIVAN, your doctor or health care provider can help you decide what schedule works for you.

If you miss a dose by more than 2 hours, wait and then take the next dose at the regularly scheduled time.

Common Cyclogyl ide effects may include:

  • CRIXIVAN does not cure HIV infection or AIDS and you may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections.

  • Gulick RM, Mellors JW, Havlir D, Eron JJ, Gonzalez C, McMahon D, Richman DD, Valentine FT, Jonas L, Meibohm A, Emini EA, Chodakewitz JA.

  • It is very important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.

  • Such increases in tamsulosin concentrations may be expected to produce clinically significant and potentially serious side effects, such as hypotension.

Long-term results are unknown, simply because the drug has only been in public consumption since March 1996. One patient, part of the earliest clinical studies, has had undetectable virus levels for more than three years. Protease inhibitors work against the HIV virus by blocking an enzyme -- the protease -- that allows the virus to reproduce. And what a reproduction factory it is: The virus can make billions of copies a day, totally regenerating its population in several days.

Without the enzyme, the virus reproduces, but in a manner that isn't infectious.

Where can I get more information?

  • Such increases in tamsulosin concentrations may be expected to produce clinically significant and potentially serious side effects, such as hypotension.

  • Bicalutamide: Bicalutamide is metabolized by cytochrome P450 3A4.