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Pimozide Indinavir inhibition of CYP3A4 can cause elevated plasma levels of pimozide, resulting in potentially life-threatening reactions. Ergot Derivatives Indinavir inhibition of CYP3A4 can cause elevated plasma levels of ergot derivatives, resulting in potentially life-threatening reactions.

Rifabutin Co-administration results in increased plasma levels of rifabutin and decreased levels of indinavir. Rifampin Rifampin induces CYP3A4, increasing the metabolism of indinavir. Cheng, in Reference Module in Biomedical Sciences, 2014.

Resistance Indinavir resistance develops rapidly with monotherapy and occurs at multiple sites. The extent of resistance is directly related to the number of codon changes in the HIV protease gene. Codon 82 is a common mutation in indinavir-resistant HIV isolates.

Nephrolithiasis and hyperbilirubinemia are both dose dependent and occur more frequently when the IDV exposure is increased by RTV boosting. Drug Interactions IDV may interact with acid suppressive agents, such as omeprazole, as it requires an acidic environment for absorption Burger et al.

Your email has been sent. PREGNANCY AND LACTATION Pregnancy MECHANISM OF ACTION Indinavir is a competitive inhibitor of HIV protease, an enzyme involved in the replication of HIV.

Oral Route Back to top About Us Help Contact Us Report Adverse Events Privacy Policy Terms of Service Rules US-based MDs, DOs, NPs and PAs in full-time patient practice can register for free on PDR. Research studies with animals found harmful effects on unborn babies. Talk with your doctor. Skip to side effects section.

Used forDosage forms2 pill images available for Crixivan indinavir PrevNextSkip side effects section. Skip to What to Expect and Pharmacists Tips section. Report a side effectPregnancyResearch studies with animals found harmful effects on unborn babies.

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It is used in the treatment of HIV infection. Crixivan capsules contain the active ingredient indinavir, which is a type of medicine called a protease inhibitor.

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Indinavir can also cause kidney stones, but drinking a minimum of 1. Indinavir, sold under the brand name Crixivan, is a type of anti-HIV drug antiretroviral called a protease inhibitor PI. Indinavir is used in combination with other anti-HIV drugs to treat but not cure HIV.

To explain how indinavir works, we need to first tell you some information about HIV. When the activity of these enzymes is reduced the production of HIV slows. Indinavir belongs to a group or class of drugs called protease inhibitors.

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Further diagnostic evaluation may be warranted, and discontinuation of CRIXIVAN should be considered in all patients with severe leukocyturia. Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including CRIXIVAN.

Patients with hemophilia: There have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitors. In some patients, additional factor VIII was required. In many of the reported cases, treatment with protease inhibitors was continued or restarted.

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People taking Crixivan are more likely to experience rash, dry skin, patches of dark skin hyperpigmentationhair loss, dry lips, and brittle fingernails and toenails. Some people may experience increases in their lipid levels triglycerides and cholesterol or diabetes risk while being treated with protease inhibitors, including Crixivan. Drug-induced hepatitis liver injury has been reported in people taking protease inhibitors, including Crixivan. This usually occurred in people who had extremely low CD4 cells, were taking multiple other medications and who were also infected with hepatitis B virus HBV or hepatitis C virus HCV.

Lab tests to monitor liver function is an important component of routine follow-up care and important for people using protease inhibitors. Other possible side effects include appetite loss, headaches, feeling crummy malaisediarrhea, nausea, vomiting, elevated creatinine levels, and elevated bilirubin levels along with yellowing of the skin and eyes.

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  • Until more data are available, it is advisable to closely monitor for adverse events when these medications are co-administered.

  • Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Crixivan have been included in the summary of product characteristics and the package leaflet.

  • Ramelteon: The serum concentrations of ramelteon may increase when ramelteon is administered with strong CYP3A4 inhibitors like the anti-retroviral protease inhibitors.

  • This usually occurred in people who had extremely low CD4 cells, were taking multiple other medications and who were also infected with hepatitis B virus HBV or hepatitis C virus HCV.

Like other protease inhibitors, use of indinavir may be associated with: redistribution or accumulation of body fat, increased blood cholesterol, and worsening of diabetes.

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  • If another agent cannot be substituted and coadministration of these agents is unavoidable, monitor patients closely for dabrafenib adverse reactions including skin toxicity, ocular toxicity, and cardiotoxicity and for loss of indinavir efficacy.

  • Trabectedin: Avoid the concomitant use of trabectedin with indinavir due to significantly increased trabectedin exposure.