Generic Name: Cyclogyl
What is Cyclogyl?
However, this interaction has not been studied. Bosutinib is a CYP3A4 substrate and indinavir is a strong CYP3A4 inhibitor. In a cross-over trial in 24 healthy volunteers, the Cmax and AUC values of bosutinib were increased 5. Brentuximab vedotin: Concomitant administration of brentuximab vedotin and indinavir may increase the exposure of monomethyl auristatin E MMAEone of the 3 components released from brentuximab vedotin.
The manufacturer suggests that potent CYP3A4 inhibitors, such as indinavir, may alter MMAE exposure as MMAE is a CYP3A4 substrate. Monitor patients for adverse reactions. Brexpiprazole: Because brexpiprazole is partially metabolized by CYP3A4, the manufacturer recommends that the brexpiprazole dose be reduced to one-half of the usual dose in patients receiving strong inhibitors of CYP3A4 such as indinavir. If these agents are used in combination, the patient should be carefully monitored for brexpiprazole-related adverse reactions.
If the co-administered CYP inhibitor is discontinued, adjust the brexpiprazole dose to its original level. Brigatinib: Avoid coadministration of brigatinib with indinavir if possible due to increased plasma exposure of brigatinib and decreased exposure to indinavir. Decreased antiretroviral concentrations may lead to a reduction of antiretroviral efficacy and the potential development of viral resistance.
Mephobarbital: Barbiturates may increase the metabolism of indinavir and lead to decreased antiretroviral efficacy. Women receiving indinavir with hormonal contraceptives should report any breakthrough bleeding or other adverse effects.
Metformin: New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have been reported with use of anti-retroviral protease inhibitors. In addition, repaglinide is a substrate of the hepatic isoenzyme CYP3A4 and the drug transporter organic anion transporting polypeptide OATP1B1protease inhibitors inhibit CYP3A4 and OATP.
Limit the saxagliptin dose to 2. New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have also been reported with use of anti-retroviral protease inhibitors. Methadone: Caution is advised with the coadministration of indinavir and methadone as concurrent use may result in incresed serum concentrations of methadone. Indinavir is a CYP3A4 inhibitor and may decrease the metabolism of methadone, a CYP3A4 substrate.
However, administration of indinavir 800 mg every 8 hours with methadone 2060 mg daily for one week, in subjects on methadone maintenance, resulted in no change in methadone AUC. Patients should be monitored for increased methadone side effects during concurrent use.
How should I take Cyclogyl?
Next Page:What should I discuss with my healthcare provider before taking indinavir Crixivan. WHO SHOULD TAKE IT. HOW IS IT TAKEN. WHAT ARE THE SIDE EFFECTS. HOW DOES IT REACT WITH OTHER DRUGS. Indinavir is a drug used as part of antiretroviral therapy ART.
What should I avoid while taking Cyclogyl?
Some patients treated with CRIXIVAN developed kidney stones. In some of these patients this led to more severe kidney problems, including kidney failure or inflammation of the kidneys or kidney infection which sometimes spread to the blood.
Drinking at least six 8-ounce glasses of liquids preferably water each day should help reduce the chances of forming a kidney stone see How should I take CRIXIVAN. Call your doctor or other health care provider if you develop kidney pains middle to lower stomach or back pain or blood in the urine.
Some patients treated with CRIXIVAN have had rapid breakdown of red blood cells hemolytic anemia which in some cases was severe or resulted in death.
Cyclogyl side effects
Pharmacist's Advice Mary Lynn Moody, RPh, BSPharmClinical Associate Professor, University of Illinois at Chicago College of PharmacyKeeping HIV infection under control requires lifelong treatment. What To Do if I Miss a Dose If it has been more than 2 hours since your missed dose, wait and take your next dose at the usual time. Never take two doses at once to try and catch up.
You could risk more serious side effects. A CD4 cell count measures the number of CD4 cells in your body.
Common Cyclogyl ide effects may include:
Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levels.
Use this combination with caution.
Many new copies of HIV are mutations.
Pediatric: The optimal dosing regimen for use of indinavir in pediatric patients has not been established.
While it does not cure AIDS, Crixivan allows HIV-positive persons to live relatively normal lives when used together with other anti-retroviral drugs such as AZT and 3TC. The drug therapy can lower the virus to undetectable levels in the blood stream for years and testing continues.
Long-term results are unknown, simply because the drug has only been in public consumption since March 1996. One patient, part of the earliest clinical studies, has had undetectable virus levels for more than three years.
Where can I get more information?
Indinavir pharmacokinetic parameters in these women were compared to those in HIV seropositive men pooled historical control data.
When initiating cariprazine in a patient who is stable on a strong CYP3A4 inhibitor, the patient should be administered 1.