Generic Name: Order crixivan
What is Order Crixivan?
Atazanavir: Atazanavir is an inhibitor of CYP3A and is associated with indirect unconjugated hyperbilirubinemia. Indinavir is a substrate of CYP3A4 and is also associated with increased unconjugated bilirubin. Concomitant use of indinavir with regimens containing cobicistat and atazanavir is contraindicated. Cobicistat is an inhibitor of CYP3A4, while both atazanavir and indinavir are CYP3A4 substates. In addition, both atazanavir and indinavir are associated with indirect unconjugated hyperbilirubinemia.
Taking these drugs together may increase the risk for hepatic adverse events, such as hyperbilirubinemia. Atorvastatin: Use caution and the lowest atorvastatin dose necessary if atorvastatin must be coadministered with indinavir. Caution is advised if these drugs are coadministered.
Avanafil: Concomitant use of avanafil and indinavir is not recommended due to the risk for increased avanafil serum concentrations and serious adverse reactions. Axitinib: Avoid coadministration of axitinib with indinavir due to the risk of increased axitinib-related adverse reactions.
Crixivan must be used in combination with other anti-HIV medicines. Find out more about it here, including how its given and possible. We explain everything you should know By Rita Ghelani Be informed.
Crixivan has also been associated with hemolytic anemia premature destruction of red blood cells and it should be stopped once the anemia is diagnosed. See chart for potential drug class side effects. Potential drug interactions: PIs interact with many other drugs. Do not use Advicor, Altoprev, Livalo, Mevacor lovastatinSimcor, Vytorin, or Zocor simvastatin for the treatment of high cholesterol.
Not recommended in combination with Reyataz.
How should I take Order Crixivan?
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What should I avoid while taking Order Crixivan?
Liotrix: Closely monitor the thyroid status of any patient taking thyroid hormones concurrently with indinavir. Lomitapide: Concomitant use of indinavir and lomitapide is contraindicated. If treatment with indinavir is unavoidable, lomitapide should be stopped during the course of treatment. The exposure to lomitapide was increased 27-fold in the presence of ketoconazole, a strong CYP3A4 inhibitor.
Loperamide: The plasma concentration of loperamide, a CYP3A4 and CYP2D6 substrate, may be increased when administered concurrently with indinavir, an inhibitor of CYP3A4 and CYP2D6. If these drugs are used together, monitor for loperamide-associated adverse reactions, such as CNS effects and cardiac toxicities i. Elevated loratadine serum concentrations do not result in clinically significant QT prolongation, ECG changes, or any significant differences in adverse reactions compared to control patients.
However, caution should be exercised with using this drug combination in a patient with concurrent risk factors for arrhythmogenic events.
Order Crixivan side effects
Methohexital: Barbiturates may increase the metabolism of indinavir and lead to decreased antiretroviral efficacy. Methylergonovine: Coadministration of ergot alkaloids with potent inhibitors of CYP3A4, like anti-retroviral protease inhibitors is considered contraindicated due to the risk of acute ergot toxicity e.
Methysergide: Coadministration of ergot alkaloids with potent inhibitors of CYP3A4, like anti-retroviral protease inhibitors is considered contraindicated due to the risk of acute ergot toxicity e. Midazolam: The use of oral midazolam and anti-retroviral protease inhibitors is contraindicated. Protease inhibitors have been shown to increase oral midazolam AUCs by up to 3-fold, resulting in clinically significant potentiation of sedation.
Lorazepam, oxazepam, or temazepam may be safer alternatives, as these benzodiazepines are not oxidatively metabolized.
Common Order Crixivan ide effects may include:
No dosage adjustments are recommended.
It is unknown whether administration of indinavir to the mother during the antenatal period will exacerbate physiologic hyperbilirubinemia in neonates.
Sirolimus: Avoid the use of sirolimus with potent CYP3A4 inhibitors, such as protease inhibitors.
Genotypic or phenotypic testing may be useful in predicting the likelihood of response to other protease inhibitors following failure of regimens containing indinavir.
New interactions are being identified all the time. Drugs to watch out for include other ARVs, drugs to treat tuberculosis see fact sheet 518for erectile dysfunction such as Viagrafor heart rhythm antiarrhythmicsand for migraine headaches. Interactions are also possible with several antihistamines allergy medicationssedatives, drugs to lower cholesterol, and anti-fungal drugs. Make sure that your health care provider knows about ALL drugs and supplements you are taking.
Where can I get more information?
This content was checked for accuracy at the time it was written.
Rilpivirine: Close clinical monitoring is advised when administering indinavir with rilpivirine due to an increased potential for rilpivirine-related adverse events.