Generic Name: Crestor
What is Crestor?
Cozaar losartan PlaceboRisks and Warnings for Cozaar losartan Skip risks section. May be used alone or with other drugs. May be given concurrently with hydrochlorothiazide. Drug isn't indicated for stroke prevention in black hypertensive patients with LVH.
Advise her to contact prescriber immediately if she suspects pregnancy. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. ActionBlocks vasoconstricting and aldosterone-secreting effects of angiotensin II at various receptor sites, including vascular smooth muscle and adrenal glands.
Children ages 6 and older: 0. Adverse reactionsCNS: dizziness, insomnia, headache, asthenia, fatigueCV: hypotensionEENT: sinus disordersGI: nausea, vomiting, diarrhea, dyspepsia, abdominal painMetabolic: hyperkalemiaMusculoskeletal: joint pain, back pain, muscle crampsRespiratory: symptoms of upper respiratory infection, dry coughOther: hypersensitivity reactions including angioedemaInteractionsDrug-drug.
The primary endpoint of this prospective study was the all-cause mortality. In this study, 3152 patients with heart failure NYHA Class II-IV were followed for almost two years median: 1. The primary endpoint did not show any statistically significant difference between losartan and captopril in reducing all-cause mortality.
In both comparator-controlled not placebo-controlled clinical studies on patients with heart failure the tolerability of losartan was superior to that of captopril, measured on the basis of a significantly lower rate of discontinuations of therapy on account of adverse reactions and a significantly lower frequency of cough.
Dual Blockade of the renin-angiotensin-aldosterone system RAAS Two large randomised, controlled trials ONTARGET ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial and VA NEPHRON-D The Veterans Affairs Nephropathy in Diabetes have examined the use of the combination of an ACE-inhibitor with an angiotensin II receptor blocker.
ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage. VA NEPHRON-D was a study in patients with type 2 diabetes mellitus and diabetic nephropathy.
Given their similar pharmacodynamic properties, these results are also relevant for other ACE-inhibitors and angiotensin II receptor blockers. ACE-inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with diabetic nephropathy.
At the end of three weeks, losartan administration once daily lowered trough blood pressure in a dose-dependent manner. Overall, there was a dose-response. The dose-response relationship became very obvious in the low dose group compared to the middle dose group period I: -6. The lowest doses studied, 2. These results were confirmed during period II of the study where patients were randomised to continue losartan or placebo, after three weeks of treatment.
How should I take Crestor?
LOSARTAN Cozaar R helps lower blood pressure to normal levels. It controls high blood pressure, but it is not a cure. High blood pressure can damage your kidneys, and may lead to a stroke or heart failure.
Losartan helps prevent these things from happening. Losartan is also used to improve symptoms in patients with heart failure. What should my health care professional know before I take losartan.
Take losartan tablets by mouth. Take your doses at regular intervals.
What should I avoid while taking Crestor?
Losartan was given at doses of 0. Amlodipine was given at doses of 0. Hypertensive patients receiving losartan experienced a reduction from baseline proteinuria of -41. The decline in both systolic blood pressure and diastolic blood pressure was greater in the losartan group -5.
In normotensive children a small decrease in blood pressure was observed in the losartan group -3. No significant correlation between the decline in proteinuria and blood pressure was noted, however it is possible that the decline in blood pressure was responsible, in part, for the decline in proteinuria in the losartan treated group.
Crestor side effects
The dose may be increased to 100 mg once daily based on blood pressure response from one month onwards after initiation of therapy. Losartan may be administered with other antihypertensive agents e. Heart FailureThe usual initial dose of losartan in patients with heart failure is 12.
The dose should generally be titrated at weekly intervals i. Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by ECGThe usual starting dose is 50 mg of losartan once daily. Special populationsFor patients with intravascular volume-depletion e.
Common Crestor ide effects may include:
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After discontinuation of losartan, PRA and angiotensin II values fell within three days to the baseline values.
Method of administration Cozaar Comp may be administered with other antihypertensive agents see sections 4.
If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking COZAAR. If you feel light-headed, dizzy or faint, get up slowly when getting out of bed or standing up. You may feel light-headed or dizzy while taking COZAAR, especially if you are also taking a diuretic fluid tablet. This may become worse if you stand up quickly as your blood pressure may fall.
Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure.
Where can I get more information?
Taking other medicinesTell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.
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