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We are not sure of the exact mechanism by which ARB's cause angioedema. Angiotensin is a chemical that your body creates that is needed to regulate blood pressure. If your blood pressure suddenly became too low, you could get a stroke. Also, adequate blood pressure is necessary for the kidneys to do their job of filtering out the blood of waste products and toxic compounds.
Angiotensin is used by the human body as a blood pressure elevator. Angiotensin acts as a powerful vasoconstrictor it causes your blood vessels to tighten up thereby reducing their inner diameter. When your body needs to ratchet up blood pressure, such as during periods of exercise or stress your body releases a tiny amount of angiotensin. Angiotensin receptor blockers form a protective shield on the blood vessels so that angiotensin's ability to tighten up your blood vessels is reduced.
If the angiotensin can't do it's job the blood vessels remain in a relaxed state and blood pressure remains low.
CozaarIs losartan available as a generic drug. GENERIC AVAILABLE: YesDo I need a prescription for losartan. YesWhat are the side effects of losartan.
Side effects reported included: Diarrhea Muscle cramps Dizziness Insomnia Nasal congestion Losartan also may cause: A persistent cough An increase serum potassium hyperkalemia Impotence Losartan may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis narrowing of both arteries going to the kidneys.
Quick GuideHow to Lower Blood Pressure: Exercise Tips Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Related Article High Blood Pressure Symptoms, Causes, Treatments What causes high blood pressure hypertension. Read more: High Blood Pressure Symptoms, Causes, Treatments Complete List Top losartan Related Articles Diabetes and Kidney DiseaseIn the United States diabetes is the most common cause of kidney failure.
High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease.
For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
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If you forget to take itIf it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your tablet s as you would normally.
If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. If you have trouble remembering to take your tablets, ask your pharmacist for some hints. If you take too much overdose Immediately telephone your doctor or Poisons Information Centre telephone 13 11 26or go to accident and emergency at your nearest hospital, if you think that you or anyone else may have taken too much COZAAR. Do this even if there are no signs of discomfort or poisoning.
If you take too many tablets, you will probably feel light-headed or dizzy.
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This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
LOSARTAN - ORAL low-SAR-tan COMMON BRAND NAME S : Cozaar WARNING: This drug can cause serious possibly fatal harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication.
Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor immediately. USES: Losartan is used to treat high blood pressure hypertension and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart.
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If you have not told your doctor about any of the above, tell them before you take any COZAAR. Taking other medicinesTell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.
Some medicines and COZAAR may interfere with each other. These include:diuretic tablets, also called fluid or water tablets, including potassium-sparing diureticspotassium tabletspotassium-containing salt substitutesmedicines used to relieve pain, swelling, and other symptoms of inflammation, for example, indomethacin. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking COZAAR.
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Because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates the diuretic-induced hyperuricemia.
Which drugs or supplements interact with losartan.
In the Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan RENAAL study involving 1513 patients treated with COZAAR or placebo, the overall incidences of reported adverse events were similar for the two groups.
Following oral administration in patients with mild-to-moderate hepatic impairment, plasma concentrations of losartan and its active metabolite were, respectively, 5 times and 1.
These medicines may have an additive effect with COZAAR in lowering your blood pressure, or may affect how well it works, or may lead to increases in potassium in your blood.
You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking COZAAR. Your doctor will tell you how many tablets you need to take each day. This depends on your condition and whether you are taking other medicines.
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Please seek medical advice before starting, changing or terminating any medication or prescription.
Do not stop taking losartan without talking to your doctor.