Generic Name: Cozaar
What is Cozaar?
Make sure you drink enough water during exercise and hot weather when you are taking COZAAR, especially if you sweat a lot. If you do not drink enough water while taking COZAAR, you may faint or feel light-headed or sick. This is because your body doesn't have enough fluid and your blood pressure is low. If you continue to feel unwell, tell your doctor. This can also mean that you are losing too much water and your blood pressure may become too low.
If your doctor has prescribed potassium tablets for you, continue taking them. COZAAR contains a very small amount of potassium, but this does not replace any potassium tablets that you may be taking. Go to your doctor regularly for a check-up.
Your doctor may occasionally do a blood test to check your potassium level in the blood and to see how your kidneys are working. Things you must not doDo not give COZAAR to anyone else, even if they have the same condition as you.
Losartan is a uricosuric. As a specific inhibitor of the urate transporter 1 URAT 1losartan blocks the uptake of uric acid into cells, thus leaving more available in the bloodstream to be filtered and excreted by the kidneys.
EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose.
Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. The terminal elimination half lives of losartan and EXP3174 are about 1. Losartan and other angiotensin-receptor antagonists exhibit fetal toxicity and should be avoided during pregnancy, particularly in the second and third trimesters.
Am J Hypertens 21:1157-1162. OX1 Agonists: Orexin A, B Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant SB-334867 SB-408124 SB-649868 Suvorexant TCS-1102 Agonists: Orexin A, B SB-668875 Antagonists: ACT-335827 ACT-462206 Almorexant EMPA Filorexant JNJ-10397049 Lemborexant MK-1064 SB-649868 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 See here instead.
Losartan is an angiotensin II receptor antagonist. Losartan is used to treat high blood pressure hypertension. Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.
What is the most important information I should know about losartan Cozaar. Stop using and tell your doctor right away if you become pregnant.
How should I take Cozaar?
More about Cozaar Generic OverviewHow to useSide effectsPrecautionsStorageDrug interactionsOverdoseMoreLosartan is used to treat high blood pressure hypertension and to help protect the kidneys from damage due to diabetes. See also Precautions section.
Missed Doses:If you miss a dose, take it as soon as you remember. Notes:Do not share this medication with others. Please seek medical advice before starting, changing or terminating any medication or prescription. Cozaar Losartan is an angiotensin receptor blocker ARB. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
What should I avoid while taking Cozaar?
Especially tell your doctor if you take:This is not a complete list of Cozaar drug interactions. Discuss the use of grapefruit products with your doctor. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. If you think you have become pregnant while using this medicine, tell your doctor right away.
Tell your doctor if you are breastfeeding or if you are planning to breastfeed. Your doctor may change your dose if needed. If it is close to your next dose, skip the missed dose and take the next dose at your regular time.
Cozaar side effects
Treatment of diabetic nephropathy in patients with type 2 diabetes. Prevention of stroke in patients with hypertension and left ventricular hypertrophy. Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II at various receptor sites, including vascular smooth muscle and the adrenal glands.
Decreased incidence of stroke in patients with hypertension and left ventricular hypertrophy effect may be less in black patients.
Lactation: Discontinue drug or use formula.
Common Cozaar ide effects may include:
This is not a complete list of possible side effects.
Merck and CoRecommended Dosage: Start with Cozaar 50 mg once daily, add 12.
The usual starting dose is one 50 mg tablet taken once a day.
In long-term follow-up studies without placebo control the effect of losartan appeared to be maintained for up to a year.
Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED - Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization.
Where can I get more information?
Pediatric Use Neonates with a history of in utero exposure to COZAAR: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion.
Contact the applicable plan provider for the most current information.