Generic Name: Order cordarone
What is Order Cordarone?
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Related Links Cordarone Injection for recurrent irregular heartbeat Cordarone Injection for recurrent rapid heartbeat leading to hemodynamic instability More about Cordarone Injection Uses Side-effects Composition Interactions Contraindications Precautions Reviews Questions What are the uses of Cordarone Injection. What are the side-effects of Cordarone Injection. What is the composition of Cordarone Injection. What other medicines does Cordarone Injection interact with.
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Cordarone Amiodarone is an anti-arrhythmic medicine. It treats heart rate problems by blocking rogue electrical signals in your heart. Cordarone Amiodarone should only be used in people with life-threatening heart rate problems. There are many potentially fatal side effects and it can make the heart rate problem worse or harder to handle. Other similar medicines should be tried first before Cordarone Amiodarone. People can start taking Cordarone Amiodarone in a hospital to watch for side effects.
This is a black box warning.
How should I take Order Cordarone?
Before switching from another antiarrhythmic drug to dofetilide therapy, the discontinued drug generally should be withheld for at least three half-lives prior to initiating dofetilide. Concurrent exposure with dofetilide could increase the risk of dofetilide-induced proarrhythmias. Because of the unpredictable pharmacokinetics of amiodarone, dofetilide should not be initiated following amiodarone therapy until amiodarone plasma levels are below 0.
Amiodarone is also an inhibitor of CYP3A4 metabolism which could reduce dofetilide metabolism. Dolasetron: Dolasetron has been associated with a dose-dependant prolongation in the QT, PR, and QRS intervals on an electrocardiogram. The concomitant use of amiodarone and other drugs known to prolong the QT interval should only be done after careful assessment of risks versus benefits, especially when the coadministered agent might decrease the metabolism of amiodarone.
Donepezil: Case reports indicate that QT prolongation and torsade de pointes TdP can occur during donepezil therapy.
What should I avoid while taking Order Cordarone?
Too high a dosage may lead to severe bradycardia and to conduction disturbances with the appearance of an idioventricular rhythm, particularly in elderly patients or during digitalis therapy. Oral Cordarone X is not contra-indicated in patients with latent or manifest heart failure but caution should be exercised as, occasionally, existing heart failure may be worsened.
In such cases, Cordarone X may be used with other appropriate therapies. Treatment should be discontinued in case of onset of 2nd or 3rd degree A-V block, sino-atrial block, or bifascicular block. Before starting amiodarone, it is recommended to perform an ECG and serum potassium measurement. Monitoring of ECG is recommended during treatment. Regular tests are recommended to ensure the proper function of the device after initiation of treatment or change in posology.
Cases of severe, potentially life-threatening bradycardia and heart block have been observed when amiodarone is used in combination with sofosbuvir in combination with another hepatitis C virus HCV direct acting antiviral DAAsuch as daclatasvir, simeprevir, or ledipasvir.
Order Cordarone side effects
Encainide: Combination therapy with encainide and amiodarone has been reported to significantly increase the risk of proarrhythmias, necessitating close monitoring. In addition, encainide is significantly metabolized by CYP2D6 isoenzymes, and amiodarone is an inhibitor of CYP2D6. Enflurane: In general, adverse cardiovascular effects such as hypotension and atropine-resistant bradycardia can occur in patients receiving amiodarone who subsequently are administered any general anesthetics, particularly volatile anesthetics.
Enzalutamide: Avoid coadministration of amiodarone and enzalutamide due to the potential for decreased serum concentrations of amiodarone and its active metabolite desethylamiodarone resulting in potential loss of efficacy. If coadministration cannot be avoided, consider monitoring of amiodarone serum concentration during concomitant use.
Amiodarone is a substrate for CYP3A and enzalutamide is a strong inducer of CYP3A4. Epirubicin: The concomitant use of amiodarone and other drugs known to prolong the QT interval should be dont only after careful assessment of risks versus benefits, especially when the coadministered agent might decrease the metabolism of amiodarone.
If these medications are given concurrently in post-myocardial infarction patients with heart failure, do not exceed an eplerenone dose of 25 mg PO once daily.
Common Order Cordarone ide effects may include:
Tell your doctor if your condition persists or worsens.
Cordarone has not been shown to help people with life-threatening heartbeat problems live longer.
However, due to the lack of clinical data, mefloquine should be used with caution in patients receiving drugs that prolong the QT interval.
Amiodarone inhibits peripheral conversion of levothyroxine T4 to triiodothyronine T3 and may cause isolated biochemical changes increase in serum free-T4, free-T3 being slightly decreased or even normal in clinically euthyroid patients.
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Amiodarone is an inhibitor of CYP3A4, CYP1A2, and CYP2C19.
Ethacrynic acid therapy may cause electrolyte abnormalities i.