Generic Name: Cordarone
What is Cordarone?
Do not dispose of medications in wastewater e. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Many of these side effects can be managed, and some may go away on their own over time.
Taking these drug together may cause the plasma concentrations of fosamprenavir and amiodarone to be altered. Foscarnet: When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as amiodarone. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP.
If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment. Fospropofol: In general, adverse cardiovascular effects such as hypotension and atropine-resistant bradycardia can occur in patients receiving amiodarone who subsequently are administered any general anesthetics, particularly volatile anesthetics. Furosemide: Monitor serum electrolytes if coadministration of furosemide and amiodarone is necessary. Furosemide therapy may cause electrolyte abnormalities i.
Galantamine: The bioavailability of galantamine may be increased by co-administration with CYP2D6 and CYP3A4 inhibitors, such as amiodarone. An increase in cholinergic side effects of galantamine may occur, particularly nausea and vomiting.
Gefitinib: Monitor for an increased incidence of gefitinib-related adverse effects if gefitinib and amiodarone are used concomitantly. Coadministration may decrease the metabolism of gefitinib and increase gefitinib concentrations. Gemifloxacin: According to the manufacturer, gemifloxacin should be avoided in patients receiving Class III antiarrhythmics such as amiodarone.
How should I take Cordarone?
Frequent medical tests are in order, as amiodarone has long lasting effects on the body. Any effect on the eye, liver or any other function of the body must be checked and rectified immediately.
Cordarone can increase the toxicity level in a person and hence it is prescribed for use only when there is no other option when other drugs have not worked. Potency of Cordarone is very high and due to the condition being treated the patient should opt to stay in a hospital during the initial week of the drug course. It is possible, though rare, that the drug can worsen the arrhythmia condition.
What should I avoid while taking Cordarone?
Promethazine carries a possible risk of QT prolongation. Additionally, amiodarone inhibits CYP2D6 and may theoretically increase concentrations of promethazine, which is metabolized by CYP2D6. Monitor for side effects like sedation and changes in heart rate or rhythm. Amiodarone inhibits CYP2D6 and may interfere with the conversion of codeine to the active metabolite, morphine. Colchicine: Coadministration of colchicine and amiodarone should be avoided due to the potential for serious and life-threatening toxicity.
If coadministration in patients with normal renal and hepatic function cannot be avoided, adjust the dose of colchicine either by reducing the daily dose or reducing the dose frequency, and carefully monitor for colchicine toxicity.
Colesevelam: Colesevelam may decrease the absorption of oral antiarrhythmics.
Cordarone side effects
There is no reason in such cases to discontinue amiodarone treatment. Hypothyroidism should be suspected if the following clinical signs occur: weight gain, cold intolerance, reduced activity, excessive bradycardia.
The diagnosis is supported by an increase in serum usTSH and an exaggerated TSH response to TRH. T3 and T4 levels may be low. Euthyroidism is usually obtained within 3 months following the discontinuation of treatment.
In life-threatening situations, amiodarone therapy can be continued, in combination with L-Thyroxine.
Common Cordarone ide effects may include:
If you experience any other symptoms which you think may be due to amiodarone, speak with your doctor or pharmacist for further advice.
Maprotiline: If possible, avoid coadministration of amiodarone and drugs known to prolong the QT interval.
Due to the above characteristics, loading doses should be used in order to obtain rapidly the tissue levels necessary to have a therapeutic effect.
Levothyroxine: Amiodarone has a complex effect on the metabolism of thyroid hormones and can alter thyroid function tests in many patients.
Postoperatively, occurrences of ARDS have been reported in patients receiving Cordarone therapy who have undergone either cardiac or noncardiac surgery. Although patients usually respond well to vigorous respiratory therapy, in rare instances the outcome has been fatal. Until further studies have been performed, it is recommended that FiO2 and the determinants of oxygen delivery to the tissues e. Patients should be advised that most manufacturers of corneal refractive laser surgery devices contraindicate that procedure in patients taking Cordarone.
Where can I get more information?
In some cases, visual impairment has progressed to permanent blindness.
Clarithromycin: Clarithromycin is associated with an established risk for QT prolongation and torsades de pointes TdP.