Generic Name: Generic combivir
What is Generic Combivir?
Impairment of Fertility Lamivudine: Lamivudine did not affect male or female fertility in rats at a dose associated with exposures approximately 130 times higher than the exposure in humans at the dose of 300 mg.
Use In Specific Populations Pregnancy Pregnancy Category C Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to COMBIVIR during pregnancy. Fetal Risk Summary There are no adequate and well-controlled trials of COMBIVIR lamivudine and zidovudine in pregnant women.
Clinical Considerations Treatment of HIV during pregnancy optimizes the health of both mother and fetus. Data Human Data: Lamivudine: Lamivudine pharmacokinetics were studied in pregnant women during 2 clinical trials conducted in South Africa. Lactation The Centers for Disease Control and Prevention recommend that HIV-1-infected mothers in the United States not breastfeed their infants to avoid risking postnatal transmission of HIV-1 infection.
Geriatric Use Clinical trials of COMBIVIR did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Patients With Impaired Renal Function COMBIVIR is not recommended for patients with creatinine clearance less than 50 mL per min because COMBIVIR is a fixed-dose combination and the dosage of the individual components cannot be adjusted. Patients With Impaired Hepatic Function COMBIVIR is a fixed-dose combination and the dosage of the individual components cannot be adjusted.
Lamivudine Because a negligible amount of lamivudine was removed via 4-hour hemodialysis, continuous ambulatory peritoneal dialysis, and automated peritoneal dialysis, it is not known if continuous hemodialysis would provide clinical benefit in a lamivudine overdose event.
Zidovudine Acute overdoses of zidovudine have been reported in pediatric patients and adults. Specific Populations Renal Impairment COMBIVIR: The effect of renal impairment on the combination of lamivudine and zidovudine has not been evaluated see the U.
In addition, tell your doctor if you are pregnant or planning to become pregnant, if you are breastfeeding, and all your medical conditions, including all prescription and over-the-counter medications and supplements you are taking. This is poll is currently not showing results, please visit our poll listing for current or past polls. You have been inactive for 60 minutes and will be logged out in.
Any updates not saved will be lost. General Info Combivir is an HIV medication. Combivir must be used in combination with other HIV drugs. Dosage Adult Dose: One tablet twice a day. PDF Other Info Before taking this medication, tell your doctor if you have kidney disease or liver disease.
Thank you for your participation. It is a combination of two antiretroviral medications, lamivudine and zidovudine.
How should I take Generic Combivir?
Children: The safety and effectiveness of using this medication have not been established for children less than 12 years of age. Lamivudine - zidovudine is not recommended for this age group. If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter non-prescriptionand herbal medications you are taking.
What should I avoid while taking Generic Combivir?
It is a combination of two antiretroviral medications, lamivudine and zidovudine. It is used together with other antiretrovirals. It is taken by mouth twice a day. The medications are both of the nucleoside reverse transcriptase inhibitor NRTI class. The drug is then incorporated to the end of the growing chain of the viral DNA causing the chain to be terminated, where nucleotides can no longer be added to the growing viral DNA.
Generic Combivir side effects
Patients receiving interferon alfa with or without ribavirin and COMBIVIR should be closely monitored for treatment-associated toxicities, especially hepatic decompensation, neutropenia, and anemia.
Discontinuation of COMBIVIR should be considered as medically appropriate. Dose reduction or discontinuation of interferon alfa, ribavirin, or both should also be considered if worsening clinical toxicities are observed, including hepatic decompensation e. Coadministration of ribavirin and COMBIVIR is not advised.
COMBIVIR should be used with caution in patients with a history of pancreatitis or other significant risk factors for the development of pancreatitis. Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including COMBIVIR.
Common Generic Combivir ide effects may include:
Comments: Compared to pegylated liposomal doxorubicin, treatment with liposomal daunoribicin yields to slightly lower remission rates of KS.
The lipoatrophy could be irreversible or fat could take a long time to rebuild after your regimen is changed.
Zidovudine showed clastogenic effects in an oral repeated dose micronucleus test in mice.
If overdose occurs, the patient should be monitored and standard supportive treatment applied as required.
Most importantly, ddI should be avoided while care should be taken with all other NRTIs like d4T. Possible antagonism with abacavir mechanism unclear. Indications and trade name: infections with Mycobacterium avium complex MAC in combination with other drugs usually ethambutol and azithromycin.
Where can I get more information?
The studies showed that the active substances taken together could reduce viral loads the level of HIV in the blood and allow CD4 cell counts to rise after up to one year of treatment.
If you forget to take them If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.