Generic Name: Combivir
What is Combivir?
Coadministration of ribavirin and zidovudine is not advised. Discontinue treatment as clinically appropriate. Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill. Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more. Zidovudine, one of the medications in this product, can decrease bone marrow function, which may lead to low numbers of red and white blood cells.
A low number of red blood cells can lead to anemia. A low number of white blood cells can decrease your body's ability to fight serious, life-threatening infections.
COMBIVIR can be taken with most other medications, including most anti-HIV drugs. Be sure to tell your doctor about all medications, over-the-counter or prescription, that you are taking. How should I store COMBIVIR Tablets. COMBIVIR Tablets may be stored at room temperature and do not require refrigeration. Individual dosing with EPIVIR plus RETROVIR, rather than COMBIVIR, should be considered for: A child under 12 years of age.
Anyone who requires dosage adjustments due to drug side effects or poor kidney function. FDA-approved HIV and AIDS Treatments HIV and AIDS Articles by Topic.
Lamivudine and zidovudine belong to a class of medications called nucleoside reverse transcriptase inhibitors NRTIs. Reverse transcriptase is a part of the human immunodeficiency virus HIV required to infect cells and to make more viruses. HIV is the virus responsible for acquired immune deficiency syndrome AIDS. Lamivudine and zidovudine are used in combination to treat HIV infection by preventing reverse transcriptase from working properly.
This medication does not cure AIDS and does not prevent it from being spread to others. It is used in combination with other anti-HIV medications to slow further growth or reproduction of HIV.
How should I take Combivir?
Double the dose on the first day. Side effects: overall good tolerability, rarely gastrointestinal complaints and elevated transaminases. Interactions, warnings: long-term treatment may lead to development of candida-resistant strains.
Side effects: nephrotoxicity, usually reversible after discontinuation. Electrolyte changes hypocalcemia, hypokalemia are also common. More rarely, anemia, neutropenia, fever, rash, headache, nausea, vomiting, diarrhea.
What should I avoid while taking Combivir?
Lamivudine: Lamivudine is a synthetic nucleoside analogue. Intracellularly, lamivudine is phosphorylated to its active 5'-triphosphate metabolite, lamivudine triphosphate 3TC-TP. The principal mode of action of 3TC-TP is inhibition of reverse transcriptase RT via DNA chain termination after incorporation of the nucleotide analogue.
Zidovudine: Zidovudine is a synthetic nucleoside analogue. Intracellularly, zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate ZDV-TP. The principal mode of action of ZDV-TP is inhibition of RT via DNA chain termination after incorporation of the nucleotide analogue.
Lamivudine plus Zidovudine: In HIV-1-infected MT-4 cells, lamivudine in combination with zidovudine at various ratios was not antagonistic. Lamivudine: The antiviral activity of lamivudine against HIV-1 was assessed in a number of cell lines including monocytes and fresh human peripheral blood lymphocytes PBMCs using standard susceptibility assays.
Combivir side effects
Nu au fost efectuate studii pentru investigarea efectelor lamivudinei si zidovudinei asupra indemanarii de a conduce masina sau de a manipula utilaje.
Astfel de efecte nu pot fi prevazute din farmacologia acestor medicamente. Cu toate acestea, starea clinica a pacientului, precum si profilul reactiilor adverse ale lamivudinei si zidovudinei nu trebuie omise atunci cand se ia in considerare capacitatea pacientului de a conduce masina sau de a manipula utilaje. Please leave this field empty. Combivir is not a cure for HIV or AIDS, and will not prevent the spread of the infection between other people.
Common Combivir ide effects may include:
Lactation The Centers for Disease Control and Prevention recommend that HIV-1-infected mothers in the United States not breastfeed their infants to avoid risking postnatal transmission of HIV-1 infection.
They belong to a group of drugs called nucleoside reverse transcriptase inhibitors NRTIs which stop the virus from replicating.
Low cost medication programs that provide prescription medication help for drugs like Combivir is sometimes, the only way that an individual can make ends meet by using these programs to help pay for medications.
How does Combivir work.
Patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities during combination antiretroviral therapy, and should be monitored according to standard practice.
If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered. Patients co-infected with hepatitis C virus: The concomitant use of ribavirin with zidovudine is not recommended due to an increased risk of anaemia see section 4.
Patients should be advised to seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.
Where can I get more information?
In a clinical trial, adverse events among HIV-1-infected women were not different among untreated women and women treated with zidovudine.