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In patients in whom myocarditis is suspected, clozapine treatment should be promptly discontinued. Orthostatic hypotension, with or without syncope, can occur with clozapine treatment. Orthostatic hypotension is more likely to occur during initial titration in association with rapid dose escalation. In patients who have had even a brief interval off clozapine, i. Since collapse, respiratory arrest and cardiac arrest during initial treatment has occurred in patients who were being administered benzodiazepines or other psychotropic drugs, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Analyses of seventeen placebo-controlled trials modal duration of 10 weeks in these patients revealed a risk of death in the drug-treated patients of between 1.

Seizures Seizures have been associated with the use of clozapine. Myocarditis Analyses of postmarketing safety databases suggest that clozapine is associated with an increased risk of fatal myocarditis, especially during, but not limited to, the first month of therapy.

Other adverse cardiovascular and respiratory effects Orthostatic hypotension, with or without syncope, can occur with clozapine treatment. Increased mortality in elderly patients with dementia-related psychosis Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo.

Fatal myocarditis and cardiomyopathy have occurred with CLOZARIL treatment. Discontinue CLOZARIL and obtain a cardiac evaluation upon suspicion of these reactions. Generally, patients with clozaril-related myocarditis or cardiomyopathy should not be rechallenged with CLOZARIL. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. The structural formula is Inactive Ingredients are colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch cornand talc.

Call your doctor right away if you have signs of infection such as:CLOZARIL is indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. CLOZARIL is indicated for reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for reexperiencing suicidal behavior, based on history and recent clinical state.

Prior to initiating treatment with CLOZARIL, a baseline ANC must be obtained. The starting dose is 12. The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day administered in divided doses by the end of 2 weeks. Subsequently, the dose can be increased once weekly or twice weekly, in increments of up to 100 mg.

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These medicines may be affected by Clozaril or they may affect how well Clozaril works. You may need to take different amounts of your medicines or you may need to take different medicines.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Clozaril. The usual starting dose is half of a 25 mg tablet once or twice on the first day. The dose is usually increased to one 25 mg tablet once or twice on the second day. After that the dose can be slowly increased until the desired effect is achieved. Usually the total amount of Clozaril needed each day will be between 200 mg and 450 mg but some people will need higher doses.

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The full benefit of Clozaril may not be seen for 6-12 weeks or longer. FDA Alerts AgranulocytosisBecause of a significant risk of agranulocytosis, a potentially life-threatening adverse effect, Clozaril should be reserved for the use in the treatment of severely ill patients with schizophrenia who fail to show an acceptable response to adequate courses of standard antipsychotics drug treatment. Patients being treated with Clozaril must have a baseline white blood cell WBC and differential count before initiation of treatment as well as regular WBC counts during treatment and for 4 weeks after discontinuation of treatment.

Clozaril is available only through a distribution system that ensures monitoring of WBC counts prior to delivery of the next supply of medication. Seizures Seizures have been associated with the use of Clozaril.

Dose appears to be an important predictor of seizure, with a greater risk at higher doses.

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How long did it take to work. The one thing that has me nervous about going on it is reducing my old meds and adding the Clozaril and finding the right dose.

Why not see how you go for a few years. Not everyoneis that lucky. Clozaril is the best medication I've ever been prescribed. However I had a rapid weight gain and it made my Cholestrol high.

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  • Consult your veterinarian to determine if other drugs your pet is receiving could interact with clozapine.

  • This would prevent the condition from suddenly coming back and decrease the chance of getting symptoms as headaches, vomiting, nausea, and diarrhea.

  • CYP2D6 And CYP3A4 Inhibitors Concomitant treatment with CLOZARIL and CYP2D6 or CYP3A4 inhibitors e.

What should I discuss with my healthcare provider before taking Clozaril. Symptoms of schizophrenia which are bothersome to you. If you had any serious side effects with other antipsychotic medications like muscle stiffness, muscle cramping, shaking, tardive dyskinesia, neuroleptic malignant syndrome, weight gain, or diabetes.

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  • Because M4 is highly expressed in the salivary gland, its M4 agonist activity is thought to be responsible for the hypersalivation.

  • FDA Alerts Agranulocytosis Because of a significant risk of agranulocytosis, a potentially life-threatening adverse effect, Clozaril should be reserved for the use in the treatment of severely ill patients with schizophrenia who fail to show an acceptable response to adequate courses of standard antipsychotics drug treatment.