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I had a lot of problem with "connecting" to people, which affected my ability to form relationships with people and my interactions with people. Clozaril helps a lot with that so I can relate to other people and "connect. For me this has been a great medication. This antipsychotic did nothing for me. Most patients grow out of there bipolar or schizophrenia by the time they turn 30 years old anyway.

This is the best. I do hate this drug for the side effects,especially the bedwetting and drooling. But what can I do. I need it for survival. The mandatory bloodwork is a major inconveinence and pain in the rump.

The odds of getting a different reaction are rare, but I've seen them happen to the degree where one cannot assume it'll never happen. If one does have a good reaction to one and not another, the specific manufacturer of that specific med must be identified and the patient must only continue that med from that specific manufacturer or avoid the med from the other manufacturer where they did not have as good an experience.

Enter search terms: in this series in this repository across all repositories Digital Commons. It is a drug prescribed for the acute and maintenance treatment of Schizophrenia in adults and in adolescents 13 to 17 years of age and for acute and maintenance treatment of manic and mixed episodes associated with Bipolar I Disorder with or without psychotic features in adults and in pediatric patients 10 to 17 years of age. SIDE EFFECTS: Seizures, myocarditis, respiratory arrest, cardiac arrest see list below.

Because of the significant risk of agranulocytosis and seizure associated with its use, Clozaril should be used only in patients who have failed to respond adequately to treatment with appropriate courses of standard drug treatments for schizophrenia, either because of insufficient effectiveness or the inability to achieve an effective dose due to intolerable adverse effects from those drugs. This is significant because it affects how soon withdrawal symptoms may appear. Clozaril is mainly metabolized through the P450 pathway in the liver and the enzymes primarily handling the metabolism are CYP3A4, CYP1A2 and CYP2D6.

The CYP enzymes are the major enzymes involved in drug metabolism, and since many drugs may increase or decrease the activity of various CYP isozymes, this is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs.

For example, if one drug inhibits the CYP-mediated metabolism of another drug, the second drug may accumulate within the body to toxic levels, possibly causing an overdose. The Food and Drug Administration FDA has decided that some drugs pose very serious risks and have required these drugs have what is called a black box warning.

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Do not double doses or take extra medicine to make up for the missed dose. If you miss two days of dosages, call your doctor before taking it again. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture preferably not in the bathroom.

Throw away any medication that is outdated or no longer needed. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk. It is recommended that you DO NOT breast-feed while taking this medicine unless your doctor or pediatrician has told you to.

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Because immediate withdrawal of treatment is required to prevent the development of life-threatening agranulocytosis, monitoring of the WBC count is mandatory see section 4. Table 3 below summarises the estimated incidence of agranulocytosis for each Clozaril treatment period. Incidence of agranulocytosis per 100,000 person-weeks2 of observation 1 From the UK Clozaril Patient Monitoring Service lifetime registry experience between 1989 and 2001.

The cumulative incidence of agranulocytosis in the UK Clozaril Patient Monitoring Service lifetime registry experience 0-11. Glucose levels normalised in most patients after discontinuation of Clozaril and in a few cases hyperglycaemia recurred when treatment was reinitiated.

Although most patients had risk factors for non-insulin-dependent diabetes mellitus, hyperglycaemia has also been documented in patients with no known risk factors see section 4.

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Prescribers are encouraged to keep a record of all patients' blood results and to take any steps necessary to prevent these patients from accidentally being rechallenged in the future. Patients with a history of primary bone marrow disorders may be treated only if the benefit outweighs the risk. They should be carefully reviewed by a haematologist prior to starting Clozaril. Patients who have low WBC counts because of benign ethnic neutropenia should be given special consideration and may only be started on Clozaril with the agreement of a haematologist.

After the start of Clozaril treatment regular WBC count and ANC must be performed and monitored weekly for the first 18 weeks, and at least at four-week intervals thereafter. At each consultation, the patient must be reminded to contact the treating physician immediately if any kind of infection, fever, sore throat or other flu-like symptoms develop.

WBC and differential blood counts must be performed immediately if any symptoms or signs of an infection occur. WBC counts and differential blood counts should then be performed daily and patients should be carefully monitored for flu-like symptoms or other symptoms suggestive of infection.

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  • Pharmacokinetics Absorption In man, CLOZARIL tablets 25 mg and 100 mg are equally bioavailable relative to a CLOZARIL solution.

  • In this situation, careful psychiatric monitoring of the patient is essential since symptoms may recur quickly.

  • Since collapse, respiratory arrest and cardiac arrest during initial treatment has occurred in patients who were being administered benzodiazepines or other psychotropic drugs, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.

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Talk to your doctor if you have questions. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

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  • For temporary relief of mouth dryness, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute.

  • When prescribing CLOZARIL, consider the presence of additional risk factors for QT prolongation and serious cardiovascular reactions.