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Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Clozaril can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. This can make it easier for you to develop a serious or life-threatening infection. Your blood will need to be tested often. Your future treatments may be delayed based on the results of these tests.
If you need surgery, tell the surgeon ahead of time that you are using Clozaril. You may need to stop using the medicine for a short time. You should not stop using Clozaril suddenly or you could have unpleasant withdrawal symptoms.
Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. A higher proportion of the CLOZARIL group demonstrated categorical increases from baseline in fasting glucose concentrations, compared to the chlorpromazine group Table 4.
The CLOZARIL doses were 100-900 mg per day mean modal dose: 512 mg per day. The maximum chlorpromazine dose was 1800 mg per day mean modal dose: 1029 mg per day. The median duration of exposure was 42 days for CLOZARIL and chlorpromazine. Clinical monitoring, including baseline and periodic follow-up lipid evaluations in patients using CLOZARIL, is recommended. In a pooled data analysis of 10 studies in adult subjects with schizophrenia, CLOZARIL treatment was associated with increases in serum total cholesterol.
No data were collected on LDL and HDL cholesterol. In a pooled data analysis of 2 studies in adult subjects with schizophrenia, CLOZARIL treatment was associated with increases in fasting serum triglyceride. In addition, CLOZARIL treatment was associated with categorical increases in serum total cholesterol and triglyceride, as illustrated in Table 6. The proportion of patients with categorical increases in total cholesterol or fasting triglyceride increased with the duration of exposure.
The median duration of CLOZARIL and chlorpromazine exposure was 45 days and 38 days, respectively.
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If the total eosinophil count continues to increase over several weeks in the absence of systemic disease, the decision to interrupt CLOZARIL therapy and rechallenge after the eosinophil count decreases should be based on the overall clinical assessment, in consultation with an internist or hematologist.
QT prolongation, Torsade de Pointes and other life-threatening ventricular arrhythmias, cardiac arrest, and sudden death have occurred with CLOZARIL treatment. When prescribing CLOZARIL, consider the presence of additional risk factors for QT prolongation and serious cardiovascular reactions. Conditions that increase these risks include the following: history of QT prolongation, long QT syndrome, family history of long QT syndrome or sudden cardiac death, significant cardiac arrhythmia, recent myocardial infarction, uncompensated heart failure, treatment with other medications that cause QT prolongation, treatment with medications that inhibit the metabolism of clozapine, and electrolyte abnormalities.
Prior to initiating treatment with CLOZARIL, perform a careful physical examination, medical history, and concomitant medication history. Consider obtaining a baseline ECG and serum chemistry panel. Discontinue CLOZARIL if the QTc interval exceeds 500 msec.
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Clozapine, but not haloperidol, produces bursts of excitatory postsynaptic potentials EPSPswhich are blocked by glutamate receptor antagonists, suggesting that these EPSPs are the result of increasing release of excitatory amino acids. Clozapine, a generic medication for Clozaril, is an atypical anti-psychotic medication - a family of drugs used to treat consumers suffering from Schizophrenia and other mental illnesses.
Clozapine is usually given to patients who fail to respond adequately to standard drug treatments for Schizophrenia. In clinical studies, consumers who received Clozapine were less likely to be hospitalized and more compliant with treatment. Clozapine has also been shown in clinical studies to reduce suicidal thoughts and behaviors that often accompany Schizophrenia. Clozapine is also known as the Golden Standard for anti-psychotic medications. In 1993 Penn Psychiatric Center established a Clozapine Clinic offering a regimented course of treatment.
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Providing help with prescription costs is what we do every day for thousands of individuals who need help with prescription drugs. Prescription drug assistance programs have many medication assistance programs available to provide help paying for medication, however, the prescription assistance program application is different for each prescription assistance program which makes it difficult to get help with medications through prescription assistance services.
Many doctors, social workers, and other groups refer individuals to Prescription Hope as the trusted source for low income prescription assistance, prescription help for uninsured patients, and many other demographics. Low cost medication programs that provide prescription medication help for drugs like Clozaril is sometimes, the only way that an individual can make ends meet by using these programs to help pay for medications.
The problem is that the details to each of the patient medication assistance plans vary widely which causes many people to be denied drug assistance programs and do not receive help with paying for prescriptions through prescriptions assistance programs.
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No paediatric studies have been performed.
It makes no sense to me - going by those criteria anyone with anorexia must be schizophrenic.
Clozaril Side Effects Along with its needed effects, a medicine may cause some unwanted effects.
Make sure you read all the printed information you are given.
Clozaril can increase the drowsiness caused by medicines that affect your nervous system. Clozaril may cause alteration in blood lipids. It may also cause weight gain. Your doctor may monitor your weight and blood lipid levels. Clozaril can cause sleepiness, and remaining in bed for prolonged duration in combination with weight gain may lead to the formation of blood clots in some patients.
Where can I get more information?
Some clinical trials have been conducted to determine its efficacy in treating bipolar disorder.
Clozaril has been known to occasionally raise blood sugar levels, causing unusual hunger, thirst, and weakness, along with excessive urination.