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It may also cause weight gain. Your doctor may monitor your weight and blood lipid levels. Clozaril can cause sleepiness, and remaining in bed for prolonged duration in combination with weight gain may lead to the formation of blood clots in some patients.
If Clozaril makes you feel light-headed, dizzy or faint, be careful when getting up from a sitting or lying position. Clozaril may lower your blood pressure, especially at the start of treatment.
These symptoms can usually be prevented by getting up slowly and flexing leg muscles and toes to get the blood flowing. When getting out of bed, dangle your legs over the side for a minute or two before standing up. You may feel dizzy or faint if you are too hot. Inform your doctor if you stop smoking or change the number of caffeine-containing drinks that you have in one day. These changes can affect the levels of this medicine in your blood.
The longer you take Clozaril, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults. This is not a complete list of side effects and others may occur. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects in more detail Initial dose: 12. Subsequent dose increases can be in increments of up to 100 mg once or twice weekly. Uses: -For the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment.
Clozaril can cause a serious heart problem, especially if you use certain medicines at the same time. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Clozaril. Taking Clozaril with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Clozaril with a sleeping pill, narcotic pain medicine, prescription cough medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
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The severe side effect is suppression of the bone marrow's ability to make infection-fighting white blood cells called neutrophils. This is a common enough side effect that at the outset of treatment, weekly blood work is required and even when one has tolerated the drug for a long time, monthly blood work is required. This drug is only available by participating in a program that checks neutrophil counts prior to each prescription.
Fatalities are not unusual on the drug. What's the Difference Between a Brand-Name Drug and a Gen. Topics Pharmacology Antipsychotic Clozapine Is it safe to take Clozaril for bipolar disorder. A Answers 2 Follow Following Unfollow Pending Disabled A Dr. Thomas JensenPsychiatry, answered on behalf of International Bipolar Foundation Clozaril was the first of the atypical antipsychotics or D2 blockers.
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Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more. While clozapine can provide great benefits, it can rarely cause serious, possibly fatal side effects.
For this reason, clozapine is used when other treatments have not worked or you cannot take them. For patients to receive this medication, all doctors, pharmacists, and patients must agree to, understand, and carefully follow the requirements of the Clozapine REMS Program. These requirements apply in the United States.
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Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Tell your doctor if you are taking any medicines, including those bought without a prescription and herbal medicines, before you start treatment with clozapine.
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In this study Clozapine was more effective in reducing the risk of suicide.
However, here at Alternative to Meds Center rehab, the methods of Clozaril withdrawal help that are employed relieve uncomfortable symptoms of withdrawal, and make this process much easier in general.
It can cause weight gain.
Your dose of clozapine may need to be adjusted, especially in the first few weeks.
Since Clozaril may be associated with thromboembolism, immobilisation of patients should be avoided. Cases of venous thromboembolism VTE have been reported with antipsychotic drugs.
Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with Clozaril and preventive measures undertaken. Patients with a history of epilepsy should be closely observed during Clozaril therapy since dose-related convulsions have been reported.
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Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Lead investigator Professor Robert Kerwin said that wider use of Clozaril could save between 50 and 100 lives a year in the UK.