Generic Celebrex

Generic Name: Generic celebrex

What is Generic Celebrex?

Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including CELEBREX, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.

Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin mediated follicular rupture required for ovulation. Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation.

Consider withdrawal of NSAIDs, including CELEBREX, in women who have difficulties conceiving or who are undergoing investigation of infertility. CELEBREX is approved for relief of the signs and symptoms of Juvenile Rheumatoid Arthritis in patients 2 years and older. Safety and efficacy have not been studied beyond six months in children. The use of celecoxib in patients 2 years to 17 years of age with pauciarticular, polyarticular course JRA or in patients with systemic onset JRA was studied in a 12-week, double-blind, active controlled, pharmacokinetic, safety and efficacy study, with a 12-week open-label extension.

Celecoxib has not been studied in patients under the age of 2 years, in patients with body weight less than 10 kg 22 lbsand in patients with active systemic features.

No overdoses of CELEBREX were reported during clinical trials. Manage patients with symptomatic and supportive care following an NSAID overdosage. There are no specific antidotes. The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 COX-2. Celecoxib is a potent inhibitor of prostaglandin synthesis in vitro.

Celecoxib concentrations reached during therapy have produced in vivo effects. In clinical trials using normal volunteers, CELEBREX at single doses up to 800 mg and multiple doses of 600 mg twice daily for up to 7 days duration higher than recommended therapeutic doses had no effect on reduction of platelet aggregation or increase in bleeding time. Because of its lack of platelet effects, CELEBREX is not a substitute for aspirin for cardiovascular prophylaxis.

It is not known if there are any effects of CELEBREX on platelets that may contribute to the increased risk of serious cardiovascular thrombotic adverse events associated with the use of CELEBREX. Inhibition of PGE2 synthesis may lead to sodium and water retention through increased reabsorption in the renal medullary thick ascending loop of Henle and perhaps other segments of the distal nephron.

How should I take Generic Celebrex?

Celebrex has no effect on methotrexate pharmacokinetics. Intervention:During concomitant use of CELEBREX and methotrexate, monitor patients for methotrexate toxicity. Intervention:During concomitant use of CELEBREX and cyclosporine, monitor patients for signs of worsening renal function.

Intervention:The concomitant use of Celecoxib with other NSAIDs or salicylates is not recommended. NSAIDs with short elimination half-lives e.

In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives e.

What should I avoid while taking Generic Celebrex?

There was no dose relationship for the incidence of gastroduodenal ulcers and the dose of CELEBREX 50 mg to 400 mg twice daily. The incidence for naproxen 500 mg twice daily was 16. There have been no large, clinical outcome studies to compare clinically relevant GI outcomes with CELEBREX and naproxen. In the CELEBREX groups, the endoscopic ulcer rate appeared to be higher in aspirin users than in non-users. However, the increased rate of ulcers in these aspirin users was less than the endoscopic ulcer rates observed in the active comparator groups, with or without aspirin.

What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory Drugs NSAIDs.

Generic Celebrex side effects

Wees daar extra alert op en raadpleeg uw arts bij maagklachten. Meestal adviseert de arts u om ook een maagbeschermer te gebruiken, zodat u maagklachten voorkomt. De werkzame stof celecoxib zit in de volgende producten: Celebrex Celecoxib Celecoxib is sinds 1998 internationaal op de markt.

In most cases, no-for several reasons. And though some research suggests that celecoxib is less likely to cause stomach bleeding, it might be more likely than naproxen to increase the risk of heart attacks and strokes. In addition, though celecoxib should be available next year as a generic and will eventually cost less than the brand-name original, it can take a year or more for savings to trickle down to consumers. For related information read: Should you still take Celebrex.

Because of the risks posed by ibuprofen or naproxen, we suggest that most people with arthritis start with appropriate doses of acetaminophen, which is safer when used properly.

Common Generic Celebrex ide effects may include:

  • Ask your doctor or pharmacist for more information.

  • The American Food and Drug Administration is monitoring the situation and is considering legislation to force Pfizer to put risk warnings on its Celebrex labels.

  • Advise patients to report symptoms of ulcerations and bleeding, including epigastric pain, dyspepsia, melena, and hematemesis to their health care provider.

  • In Canada - Call your doctor for medical advice about side effects.

Studies show that NSAIDs inhibit the growth of polyps and reduce the number of polyps. How Does Celebrex Work. Celebrex is an NSAID that belongs to the COX-2 inhibitor class.

More about Generic Celebrex

Consumer resources

Other brands:imitrex

Professional resources

Where can I get more information?

  • If abnormal liver tests or renal tests persist or worsen, CELEBREX should be discontinued.

  • Children age 2 and older weighing 25 kg or more: 100 mg P.