Generic Name: Celebrex
What is Celebrex?
Patients received CELEBREX 400 mg twice daily 4-fold and 2-fold the recommended OA and RA doses, respectivelyibuprofen 800 mg three times daily or diclofenac 75 mg twice daily common therapeutic doses. The primary endpoint of this outcome study was the incidence of complicated ulcers gastrointestinal bleeding, perforation or obstruction. Differences in the incidence of complicated ulcers between CELEBREX and the combined group of ibuprofen and diclofenac were not statistically significant.
The Kaplan-Meier rate for complicated ulcers at 9 months was 1. The estimated cumulative rates at 9 months of complicated and symptomatic ulcers for patients treated with CELEBREX 400 mg twice daily are described in Table 4.
Table 4 also displays results for patients less than or greater than 65 years of age. The difference in rates between CELEBREX alone and CELEBREX with ASA groups may be due to the higher risk for GI events in ASA users.
In a small number of patients with a history of ulcer disease, the complicated and symptomatic ulcer rates in patients taking CELEBREX alone or CELEBREX with ASA were, respectively, 2.
More serious side effects can occur and this is not a complete list of possible side effects associated with Celebrex. Using Celebrex increases the risk of serious conditions involving the stomach and intestines, including bleeding, ulceration, and perforation forming a hole in the wall of the stomach or intestines.
These conditions can be life-threatening and can occur without warning at any time during treatment with Celebrex. Because of this risk, people with a history of stomach ulcers or bleeding should not use Celebrex. The risk is also increased in elderly patients over the age of 65 and with longer duration of therapy. If you are concerned about the safety of Celebrex use, talk to your doctor for information based on your specific circumstances.
Contact your doctor right away if you have symptoms of bleeding from your digestive tract. These include black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications.
Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. These include antidepressants like monoamine oxidase inhibitors MAOIstricyclic antidepressants, and selective serotonin reuptake inhibitors SSRIs.
Mood stabilizers lithium, valproic acidantipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications insulin, sulfonylureas, and thiazolidinedionesantihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors.
How should I take Celebrex?
Seek medical help immediately if you experience symptoms of an allergic reaction such as trouble breathing, severe dizziness, rash, or itching or swelling of the face, tongue and throat. Question: Oh yeah I know we are all surviving this awful conditionit has completely ruin my life and it has change me so much that I'm in a fight with itand yes I thank everyday God for giving me one more year and not let this disease defeat me.
No hard feelings at all. When I am in a flare up my pain is horrible and my pain management Dr wants to start methotrexate but my rheumatologist wants me to wait another few months to see if plaquinel will start working.
It's my pain and I've waited 4 months and it's not working.
What should I avoid while taking Celebrex?
Examples of drugs which are metabolised by CYP2D6 are antidepressants tricyclics and SSRIsneuroleptics, anti-arrhythmic drugs, etc. The dose of individually dose-titrated CYP2D6 substrates may need to be reduced when treatment with celecoxib is initiated or increased if treatment with celecoxib is terminated.
Concomitant administration of celecoxib 200 mg twice daily resulted in 2. These increases are due to celecoxib CYP2D6 inhibition of the CYP2D6 substrate metabolism. CYP2C19 InhibitionIn vitro studies have shown some potential for celecoxib to inhibit CYP2C19 catalysed metabolism. The clinical significance of this in vitro finding is unknown.
Celebrex side effects
Can be taken with or without food, and take with a glass of water. In New Zealand this medicine is not subsidised by the government and patients have to pay the full cost. You may wish to register your interest area see register area of interest. All mail is reviewed by our medical team. Concerns that Celebrex may increase the risk of heart attack could keep what is still a relatively safe medication away from patients who suffer from arthritis and other painful ailments, some doctors say.
Mark Lema, chairman of the Department of Anesthesiology at the University at Buffalo, part of the State University of New York system. Celebrex belongs to a class of pain relievers known as COX-2 inhibitors.
Common Celebrex ide effects may include:
NSAIDs and some other medicines can interact with each other and cause serious side effects.
If CELEBREX is used in patients with advanced renal disease, monitor patients for signs of worsening renal function.
All nonsteroidal anti-inflammatory drugs NSAIDs may have a similar risk.
Controlled studies in pregnant women show no evidence of fetal risk.
NSAIDs non steroidal anti inflammatory drugs as a class have been shown to be associated with an increased risk of cardiovascular events such as heart attacks and strokes. There is a theory that the risk may be increased with longer duration of use of this type of medication or if patients have a history of cardiovascular disease or risk factors. The gastrointestinal warnings state that NSAIDs as a class can increase the risk of gastrointestinal irritation, ulceration, bleeding and perforation.
Celebrex is contraindicated for treatment of pain after surgery of coronary artery bypass graft surgery due to increased risk of heart attacks and strokes.
This is not an inclusive list of all possible side effects of Celebrex.
Where can I get more information?
A: How often you should take Celebrex celecoxib depends upon the reason for treatment.
It finds that Celebrex, a drug similar to ones withdrawn 12 years ago for safety reasons, is no riskier for the heart than some other prescription pain pills that are much tougher on the stomach.